Abstract：
:Prefrontal impairments have been hypothesized to be most strongly associated with the cognitive and emotional dysfunction in depression. Recently, white matter microstructural abnormalities in prefrontal lobe have been reported in elderly patients with major depressive disorder (MDD) using diffusion tensor imaging (DTI). However, it is still unclear whether the same changes exist in younger patients. In the present study, we first utilized DTI to detect prefrontal white matter in young adults with MDD. Nineteen first-episode, untreated young adults with MDD and twenty age- and gender-matched healthy controls were recruited. DTI and localizing anatomic data were acquired. Then, the regions of interest (ROIs) were located in prefrontal white matter at 4 mm inferior, and 0, 4, 8, 12, 16 and 20 mm superior to the anterior commissure-posterior commissure (AC-PC) plane, respectively. Compared with healthy controls, patients with MDD showed significantly lower fractional anisotropy (FA) values in prefrontal white matter at bilateral 20 mm, right 16 mm and right 12 mm above the AC-PC. Furthermore, there was no significant correlation between the FA value of any ROI and illness course as well as severity of depression. Together with previous findings, the present results suggest that microstructural abnormalities in prefrontal white matter may occur early in the course of MDD and may be related to the neuropathology of depression throughout adulthood from young to elderly.
journal_name
Brain Resjournal_title
Brain researchauthors
Li L,Ma N,Li Z,Tan L,Liu J,Gong G,Shu N,He Z,Jiang T,Xu Ldoi
10.1016/j.brainres.2007.06.094subject
Has Abstractpub_date
2007-09-07 00:00:00pages
124-8eissn
0006-8993issn
1872-6240pii
S0006-8993(07)01639-3journal_volume
1168pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:We have examined the role of the octopamine-containing buccal OC interneuron in the fictive feeding rhythm generated by depolarizing a modulatory interneuron, SO, in the isolated central nervous system (CNS) of Lymnaea stagnalis. Before stimulating the SO, the initial fictive feeding rate was 2.0+/-0.37 bites/min (mea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02968-1
更新日期：2000-12-22 00:00:00
abstract：:Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02797-5
更新日期：2003-07-04 00:00:00
abstract：:Acute noradrenergic stimulation has previously been shown to stimulate brain (Na+, K+)-adenosine triphosphatase activity. Effects of repeated stimulation with piperoxane were examined in the present study. Daily piperoxane increased ouabain binding, measured 24 h after the last dose, after 4 days or 3 weeks treatment;...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90258-4
更新日期：1981-06-01 00:00:00
abstract：:The purposes of this research were to quantify gravity receptor function in inbred mouse strains and compare vestibular and auditory function for strain- and age-matched animals. Vestibular evoked potentials (VsEPs) were collected for 19 inbred strains at ages from 35 to 389 days old. On average, C57BL/6J (35 to 190 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.066
更新日期：2006-05-26 00:00:00
abstract：:This study was done in urethane anesthetized, ovariectomized (OVX) female rats that were either implanted or not implanted with silastic capsules containing17β-estradiol (E2) to investigate the effect of systemic changes in E2 on the discharge rate of subfornical organ (SFO) neurons that projected to supraoptic nucleu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.06.038
更新日期：2013-08-14 00:00:00
abstract：:Corticotropin-releasing factor (CRF) and dynorphin-related peptides are co-localized within a subset of hypothalamic neurons suggesting the possibility of their co-release. Therefore, studies were performed in conscious unrestrained rats to examine whether dynorphin-related peptides modify the central nervous system (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90713-0
更新日期：1989-05-29 00:00:00
abstract：:We have used magnetic resonance imaging (MRI) of the living rat brain to longitudinally analyze the ontogenesis of an ibotenic acid lesion targeted at the piriform cortex. The MRI data were systematically compared with data obtained from a battery of histopathological techniques, including Nissl stain, hematoxylin sta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00058-3
更新日期：1996-04-29 00:00:00
abstract：:Administration of sheep red blood cells (10(6) cells, i.p.) resulted in central norepinephrine (NE) and dopamine (DA) changes which corresponded with the time of the peak immune response. These amine variations, however, appeared to be specific to certain brain regions. The increased accumulation of the NE metabolite,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90117-e
更新日期：1991-08-23 00:00:00
abstract：:The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron-astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyte cell numbers. A reduced ge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.015
更新日期：2014-11-24 00:00:00
abstract：:We investigated the influence of muramyl dipeptide (MDP), a cell wall component of Gram-positive bacteria, on cytokine-induced nitric oxide (NO) production in rat primary astrocytes. MDP alone did not induce NO release in astrocyte cultures. However, MDP increased astrocyte NO production and subsequent nitrite accumul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02920-6
更新日期：2000-11-10 00:00:00
abstract：:Nodes of Ranvier in the central nervous system in mammals are characterized by the presence of perinodal astrocytic processes. This study examines the association between processes of radial glia and the axolemma at nodes of Ranvier in the spinal cord of the mature axolotl, an animal in which radial glia represent a l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90595-m
更新日期：1991-05-17 00:00:00
abstract：:Ligation of CD27, a member of the tumor necrosis factor (TNF) receptor family, by its ligand CD70 is thought to be important in T cell activation, expansion and survival, B cell activation, and NK cell activation. We examined the role of CD70 in Theiler's murine encephalomyelitis virus-induced demyelinating disease (T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.058
更新日期：2010-03-04 00:00:00
abstract：:Previous work has demonstrated that the GABAergic system is involved in sexual differentiation of the rodent hypothalamus. The present study was designed to further examine this involvement by investigating developmental sex differences in GAD(65) protein levels in hypothalamic and extrahypothalamic brain regions know...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03167-5
更新日期：2001-12-20 00:00:00
abstract：:Systemic administration of kainic acid in the rat results in the development of a characteristic excitotoxic syndrome, consisting of automatisms (wet dog shakes, WDS), sustained limbic seizures and brain damage. Since kainate increases the release of excitatory amino acid neurotransmitters such as glutamate, this synd...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90227-5
更新日期：1994-08-01 00:00:00
abstract：:Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation initiation in the absence of an AUG start codon across a wide variety of...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.04.003
更新日期：2016-09-15 00:00:00
abstract：:The aim of this study was to determine if a prolonged period (7 or 14 days) of hypodynamia-hypokinesia (HH) affects the conduction of afferent input and the cortical and spinal responsiveness. Acute recordings of cortical and spinal somatosensory evoked potentials (SEPs) were performed after stimulation of the sciatic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02804-x
更新日期：2003-07-18 00:00:00
abstract：:This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. Oral phenidone (200 mg/kg) significantly suppressed the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.017
更新日期：2005-02-28 00:00:00
abstract：:The present work evaluated the reproducibility and variance of the cerebral blood flow (CBF) response to natural whisker stimulation in the barrel cortex of awake behaving mice. The animal was placed on an air float ball that allowed the animal to walk, while the head of the animal was fixed in a custom-made stereotac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.007
更新日期：2011-01-19 00:00:00
abstract：:Clinically, treatment options where fetal distress is anticipated or identified are limited. Allopregnanolone is an endogenous steroid, that positively modulates the GABA(A) receptor, and that has anti-apoptotic and anti-excitotoxic actions, reducing brain damage in adult animal models of brain injury. We sought to de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.11.035
更新日期：2012-01-18 00:00:00
abstract：:The pre- and postsynaptic elements of the calyx-type synapse in the chick ciliary ganglion were stained with Lucifer yellow in situ, and the structure of this synapse was examined after enzymatic dissociation of the ganglion. Back-staining of the ciliary nerve resulted in darkly stained neuronal cell bodies. Foreward-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91309-6
更新日期：1987-09-22 00:00:00
abstract：:Biochemical analysis of the binding of [125I]Bolton-Hunter coupled substance P [( 125I]BH-SP) to slide-mounted sections of rat brain demonstrated that [125I]BH-SP labels a binding site with a structure-activity profile characteristic of a substance P receptor. Under optimized preincubation and incubation conditions, t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91009-6
更新日期：1984-08-20 00:00:00
abstract：:Two distinct families of low-molecular-weight toxins (argiotoxins) have been isolated from the venom of the orb-web spider. Argiope trifasciata. The toxins have been purified to homogeneity and characterised by spectroscopic, mass spectrometric and microchemical analysis. The major biologically active member of the fi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91098-0
更新日期：1988-05-10 00:00:00
abstract：:A modified glyoxylic acid technique was used to examine central and peripheral nervous tissues in Aplysia californica. In addition to confirming the distribution of catecholamines and serotonin in the central nervous system, the method demonstrated the presence of monoamines in the opaline gland and bag cell clusters ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91081-8
更新日期：1983-01-17 00:00:00
abstract：:The dentate gyrus is believed to play an important pathophysiological role during experimentally induced kindling. In this study, we investigated whether an altered content of the calcium binding protein calbindin-D(28k) or an increased intrinsic excitability of hippocampal granule cells contribute to the induction of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.10.060
更新日期：2005-01-25 00:00:00
abstract：:The effects of amphetamine were examined in a brain stimulation reward paradigm in which response rate was measured across a range of stimulation frequencies. Both low (0.0625 and 0.125 mg/kg) and high (1.0, 2.0 and 4.0 mg/kg) doses of systemic amphetamine decreased the stimulation frequency needed to sustain low rate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90653-1
更新日期：1988-09-06 00:00:00
abstract：:We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also supp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91498-8
更新日期：1986-11-29 00:00:00
abstract：:Rats received 1-stage bilateral and sequential unilateral (serial) lesions of the posterior hypothalamus and were tested for the ability to regulate body temperature after a lengthy recovery period. The groups with lesion differed from the sham-operated groups in the cold, although not under ambient or warm conditions...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90309-7
更新日期：1981-08-31 00:00:00
abstract：:Beta-amyloid peptide (Aβ) has a causal role in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that Aβ can disrupt excitatory glutamatergic synaptic function at synaptic level. However, the underlying mechanisms remain obscure. In this study, we recorded evoked and spontaneous EPSCs in hippoca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.03.049
更新日期：2013-06-17 00:00:00
abstract：:ERPs were acquired in the test phases of three memory experiments, where three classes of word were presented. These were: (i) words encountered in a prior study phase (studied words), (ii) words presented at test for the first time (new words), and (iii) new words repeated after a lag of 7-9 intervening words (repeat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.095
更新日期：2006-10-09 00:00:00
abstract：:The purpose of the present study is to characterize the striatum of the lamprey by immunohistochemical and tracing techniques. Cells immunoreactive for GABA and substance P (SP), and positive for acetylcholinesterase, are present in the lamprey striatum. Immunoreactive (ir) fibers were detected by antisera raised agai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00701-4
更新日期：1997-08-22 00:00:00
