Abstract：
:The effects of amphetamine were examined in a brain stimulation reward paradigm in which response rate was measured across a range of stimulation frequencies. Both low (0.0625 and 0.125 mg/kg) and high (1.0, 2.0 and 4.0 mg/kg) doses of systemic amphetamine decreased the stimulation frequency needed to sustain low rates of responding; high doses decreased the maximal response rates that were sustained by the highest stimulation frequencies. Ipsilateral microinjections (2.5, 5.0 and 10.0 micrograms/0.5 microliter) of D-amphetamine sulfate into the nucleus accumbens also caused shifts to the left of the rate-frequency function; no central dose caused a change in the asymptotic response rate associated with high stimulation frequencies. Contralateral injections of D-amphetamine (10.0 micrograms) also shifted the rate-frequency functions to the left, but were much less potent. Ipsilateral injections of D-amphetamine into the caudate were also less potent, suggesting nucleus accumbens rather than more dorsal tissue as the site of this behavioral action. Also less potent were the effects of L-amphetamine, ruling out non-specific effects of pH, osmolarity and the like and also ruling out noradrenergic actions as explanations of the behavioral effects of the injections. These data suggest that nucleus accumbens is a site of amphetamine's reward-enhancing and threshold-lowering effects on brain stimulation reward.
journal_name
Brain Resjournal_title
Brain researchauthors
Colle LM,Wise RAdoi
10.1016/0006-8993(88)90653-1subject
Has Abstractpub_date
1988-09-06 00:00:00pages
361-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(88)90653-1journal_volume
459pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Excitatory amino acid neurotoxicity and the inflammatory response are suspected as mediators of some of the pathological sequelae occurring as a result of spinal cord injury. Here we report temporal and regional increases of the NMDA receptor agonist, quinolinic acid (QUIN), in an experimental model of spinal contusio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91560-1
更新日期：1994-01-07 00:00:00
abstract：:Excitotoxic effects leading to neuronal cell degeneration are often accompanied by a prolonged increase in the intracellular level of Ca(2+) ions and L-glutamate-induced toxicity is assumed to be mediated via a Ca(2+)-dependent mechanism. Due to their buffering properties, EF-hand Ca(2+)-binding proteins (CaBPs) can a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02753-1
更新日期：2002-08-02 00:00:00
abstract：:Melatonin is a hormone that mostly produced from the pineal gland, and it performs as a strong neuroprotectant to both neuron and glial cells against methamphetamine (METH)-induced neurotoxicity. Recently, it has been found that METH also damages the blood brain barrier (BBB) structure and function. However, the prote...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.08.045
更新日期：2016-11-01 00:00:00
abstract：:This study compared the responsivity of alpha 2-adrenoceptors to agonists in normotensive (WKY) and genetically hypertensive (SH) rats. Clonidine produced a greater degree of analgesia in SH as compared to WKY rats. This analgesia was antagonized by yohimbine. Neither naphazoline nor 4-hydroxy-clonidine produced analg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90340-8
更新日期：1984-06-25 00:00:00
abstract：:The prefrontal cortex (PFC) plays a central role in preparatory and anticipatory attentional processes. To investigate whether subregions of the PFC play differential roles in these processes we investigated the effect of focal lesions to either lateral prefrontal (lateral PFC; n=11) or orbitofrontal cortex (OFC; n=13...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.06.017
更新日期：2013-08-21 00:00:00
abstract：:In most cases obesity, a major risk factor for diabetes mellitus type 2 and other associated chronic diseases, is generated by excessive eating. For a better understanding of eating behavior, it is necessary to determine how it is modulated by factors such as the calorie content of food, satiety and gender. Twelve hea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.04.030
更新日期：2010-09-02 00:00:00
abstract：:We have examined the question of whether alpha-tubulin is detyrosylated during axonal transport in retinal ganglion cell axons and axons of spinal motor neurons. The degree of tyrosylation of alpha-tubulin was estimated from immunocytochemistry and immunoblotting with two anti-alpha-tubulin monoclonals, one of which (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90697-9
更新日期：1986-08-27 00:00:00
abstract：:Injections of HRP throughout the upper tectal strata led in 4 cases to the appearance of retrogradely labeled neurons within n.isthmi ventralis, contralateral to the experimental side. An additional case proved that this projection courses through the ventral supraoptic commissure. This is the first description of a c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90501-5
更新日期：1989-02-27 00:00:00
abstract：:The use of two different radioligands, [125I]Leu8, D-Tryp22,Tyr25-somatostatin-28 and the stable somatostatin octapeptide analog [125I]204-090, D-Phe-Cys[125I]Tyr-D-Trp-Lys-Thr-Cys-Thr(ol), allowed to differentiate between two somatostatin receptor subpopulations in the human cortex. In homogenates, octapeptide somato...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90813-4
更新日期：1987-03-17 00:00:00
abstract：:Dorsal temporal pole (dTP) is a cortical region at the rostral end of the superior temporal gyrus that forms part of the ventral auditory object processing pathway. Anatomical connections with frontal and medial temporal areas, as well as a recent single-unit recording study, suggest this area may be an important part...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.12.025
更新日期：2016-06-01 00:00:00
abstract：:Although the role of STAT3 in cell physiology and tissue development has been largely investigated, its involvement in the development and maintenance of nervous tissue and in the mechanisms of neuroprotection is not yet known. The potentially wide range of STAT3 activities raises the question of tissue- and gender-sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.074
更新日期：2010-11-29 00:00:00
abstract：:Protein phosphatases (PPs) regulate many substrates implicated in learning and memory. Conditioned taste aversion (CTA) learning, in which animals associate a novel taste paired with a toxin and subsequently avoid the taste, is dependent on several serine/threonine phosphatase substrates and the PP1-binding protein sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.06.029
更新日期：2010-08-12 00:00:00
abstract：:This study used microdialysis to measure changes in extracellular acetylcholine (ACh) content in the nucleus accumbens (NAC) of freely moving rats during acute and chronic morphine treatment, and following naloxone-precipitated withdrawal. Morphine injection (20 mg/kg, i.p.) caused a significant decrease in extracellu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91616-9
更新日期：1991-10-11 00:00:00
abstract：:Hyperacusis, a marked intolerance to normal environmental sound, is a common symptom in patients with tinnitus, Williams syndrome, autism, and other neurologic diseases. It has been suggested that an imbalance of excitation and inhibition in the central auditory system (CAS) may play an important role in hyperacusis. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.008
更新日期：2012-11-16 00:00:00
abstract：:Cholecystokinins in rat cerebral cortex were studied by radioimmunoassay using an antiserum specific for the COOH-terminus of CCK8. Total concentrations of immunoreactive CCK in cortex were 3-4 fold higher than in jejunum. Rat cerebral CCK was purified by immuno-affinity adsorption to the IgG fraction of CCK antisera ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90564-8
更新日期：1980-04-21 00:00:00
abstract：:We have found that daily subcutaneous injection with a maximum tolerated dose (MTD) of the mGluR2/3 agonist LY379268 (20mg/kg) beginning at 4 weeks dramatically improves the phenotype in R6/2 mice. For example, we observed normalization of motor function in distance traveled, speed, the infrequency of pauses, and the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.07.026
更新日期：2012-09-14 00:00:00
abstract：:Experiments were done in cats to identify neurons in the paramedian reticular nucleus (PRN) sending collateral axons to the region of the intermediolateral nucleus (IML) at different levels of the thoracic cord by using lectin-conjugated horseradish peroxidase (HRP) and double-labeling fluorochrome histochemistry to r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90377-5
更新日期：1987-04-07 00:00:00
abstract：:Using a co-culture model, we showed that diffusible factors from arcuate nucleus (AN) specifically increased the number and the size of hypothalamic neurons producing melanin-concentrating hormone (MCH). In this model neurite outgrowth and contacts between MCH neurons and dopaminergic neurons were also prominently inc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90948-m
更新日期：1993-11-19 00:00:00
abstract：:Sleep deprivation leads to cognitive impairments in humans and, if sustained for 2-3 weeks in rats, it is invariably fatal. It has been suggested that neural activity associated with waking, if it is not interrupted by periods of sleep, may damage brain cells through excitotoxic or oxidative mechanisms and eventually ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01768-0
更新日期：1999-09-04 00:00:00
abstract：:Increasing doses (0.1, 1.0, 10.0 mg/kg) of scopolamine were systemically (i.p.) administered to rats subjected to moderate fluid percussion brain injury. Scopolamine treatment (1.0 mg/kg, i.p.) 15 min prior to trauma significantly reduced mortality and the duration of transient behavioral suppression assessed by a var...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91104-3
更新日期：1988-05-10 00:00:00
abstract：:The spatio-temporal characteristics of release of acetylcholinesterase from the in vivo substantia nigra can now be described using a chemiluminescent reaction. Electrical stimulation of the striatum caused an increase in release of acetylcholinesterase within the ipsilateral substantia nigra; however, this increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90128-5
更新日期：1989-12-25 00:00:00
abstract：:We assessed the application of a replication deficient recombinant adenovirus vector as a retrograde tracer in neural pathway studies. The adenovirus vector, Ad. RSV betagal, containing the intracellular marker gene, beta-galactosidase, was injected directly into the laterodorsal striatum of rats. The retrograde trans...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01065-3
更新日期：1995-12-24 00:00:00
abstract：:Recent findings have shown that systemic morphine increases extracellular dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), ascorbic acid (AA) and uric acid concentrations in the striatum of freely moving rats. The morphine-induced increase in DA oxidative metabolism is highly correlated with...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00371-0
更新日期：1998-06-22 00:00:00
abstract：:Previous research with deafferented subjects suggests that efference copy can be used to update limb position. However, the contributions of efference copy to limb localization are currently unclear. We examined the performance of JDY, a woman with severe, longstanding proprioceptive deficits from a sensory peripheral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.063
更新日期：2010-10-08 00:00:00
abstract：:Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90752-7
更新日期：1983-10-16 00:00:00
abstract：:Rats exposed to inescapable tailshock exhibit deficits in learning a simple shuttlebox escape task 24 h later. This syndrome has been termed 'behavioral depression' or 'learned helplessness', and is a model of stress-induced depression. In the present study a significant (25%) decrease in GABA receptor-mediated chlori...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90938-4
更新日期：1989-05-15 00:00:00
abstract：:The regulation of circadian rhythms changes with age. In humans, changes in the timing of sleep and wakefulness are especially common. In Syrian hamsters Mesocricetus auratus the free running period of the activity/rest rhythm shortens with age. The present study tested the hypothesis that critical age-related changes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00423-n
更新日期：1995-07-17 00:00:00
abstract：:When N-methyl-D,L-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90076-2
更新日期：1982-10-14 00:00:00
abstract：:Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other region...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90667-0
更新日期：1986-01-15 00:00:00
abstract：:Neuron-specific enolase (NSE) has been localized only in neurons and cells with characteristics of neurons. The immunocytochemical localization of NSE was examined in guinea pig cochleae to determine if hair cells, which have some neuronal characteristics, would show NSE-like immunoreactive labeling. NSE-like immunore...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91541-0
更新日期：1985-02-18 00:00:00
