Abstract：
:The dentate gyrus is believed to play an important pathophysiological role during experimentally induced kindling. In this study, we investigated whether an altered content of the calcium binding protein calbindin-D(28k) or an increased intrinsic excitability of hippocampal granule cells contribute to the induction of the kindling phenomenon. We determined the firing pattern of granule cells in hippocampal slices using perforated patch-clamp recordings in current clamp mode. The expression of calbindin-D(28k) and glutamic acid decarboxylase (GAD(67)) by granule cells was analyzed immunohistochemically. Rats developed secondarily generalized limbic seizures within approximately 11 days of twice-daily stimulation of the amygdala. As reported for other kindling paradigms, this protocol induced a clear up-regulation of GAD(67) in granule cells, indicating their involvement in the induced neuronal activity. However, when comparing kindled and control rats, we could not detect any differences in intrinsic excitability: Firing frequency, after-hyperpolarisations, action potentials, input resistance and membrane potentials were nearly identical between both groups. Furthermore, we did not observe any differences in the calbindin-D(28k) immunoreactivity between groups. In every slice, virtually all granule cells were found to be strongly calbindin-D(28k) positive, and there was no apparent reduction in the general level of calbindin-D(28k) expression. We conclude that changes in intrinsic membrane properties or in the calbindin-D(28k) content of granule cells are not necessary for the development of amygdala kindling.
journal_name
Brain Resjournal_title
Brain researchauthors
Dietrich D,Podlogar M,Ortmanns G,Clusmann H,Kral Tdoi
10.1016/j.brainres.2004.10.060subject
Has Abstractpub_date
2005-01-25 00:00:00pages
123-30issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(04)01789-5journal_volume
1032pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Clinically, treatment options where fetal distress is anticipated or identified are limited. Allopregnanolone is an endogenous steroid, that positively modulates the GABA(A) receptor, and that has anti-apoptotic and anti-excitotoxic actions, reducing brain damage in adult animal models of brain injury. We sought to de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.11.035
更新日期：2012-01-18 00:00:00
abstract：:Migraine and anxiety disorders are frequently co-morbid with balance disorders. This study examined the relative distribution of subtypes of serotonin (5-HT) receptor in the inner ear of monkeys and rats. Most vestibular ganglion cells were immunoreactive for 5-HT(1B) and 5-HT(1D) receptors in macaques and rats. In th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.057
更新日期：2010-07-30 00:00:00
abstract：:The ability of the monoclonal antibody, 192-IgG, directed against the rat nerve growth factor (NGF) receptor to mimic or inhibit the actions of NGF was examined in vitro and in vivo. 192-IgG had no effect on morphology, survival, or protein synthesis rates of sympathetic neuronal cultures. When injected into newborn r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91491-1
更新日期：1989-01-23 00:00:00
abstract：:This study investigated the effects of morphine microinjection into the nucleus raphe magnus (RMg) on electrically evoked C-fiber activities of convergent neurons in the spinal trigeminal nucleus oralis (Sp5O), in halothane-anesthetized rats. Although the neurons could be depressed by systemic morphine (6 mg/kg, i.v.)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00659-3
更新日期：1998-08-24 00:00:00
abstract：:Maternal care is crucial for offspring development and licking/grooming patterns can be induced by sensorial, neuroendocrine, and metabolic variations in the CNS. Important brain functions, such as learning and memory, can be influenced by oxidative stress, which can also modulate pathophysiological processes (e.g., d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.11.010
更新日期：2017-01-15 00:00:00
abstract：:Radioligand-binding studies were performed to ascertain the actions of noribogaine, a suspected metabolite of ibogaine, on opioid receptors. Consistent with previous results, ibogaine showed highest affinity for kappa opioid receptors (Ki = 3.77 +/- 0.81 microM), less affinity for mu receptors (Ki = 11.04 +/- 0.66 mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00123-8
更新日期：1995-03-27 00:00:00
abstract：BACKGROUND:It is unclear whether spinal cord stimulation (SCS) at higher frequencies induces further increases in vasodilation and enhances clinical efficacy. OBJECTIVES:This study investigated effects of SCS at both a normal frequency (as used clinically) and two higher frequencies on peripheral vasodilation. METHOD...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.072
更新日期：2010-02-08 00:00:00
abstract：:The stimulated (40 Hz) release of enkephalin from the myenteric plexus can be modulated by multiple types of opiate receptor. The direction of the modulation is not fixed but is bimodal. Both an inhibition and an enhancement of evoked release is observed depending on the concentration of opioid agonist that is used. E...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91594-1
更新日期：1989-12-11 00:00:00
abstract：:Experiments were performed to test the hypothesis that subarachnoid hemorrhage (SAH) causes functionally relevant perturbations of cyclooxygenase activity in cerebral arteries. Four groups of rabbits were formed: (I) controls; (II) sham injected animals (2 ml physiological solution in the cisterna magna); (III) SAH gr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00053-5
更新日期：1998-04-20 00:00:00
abstract：:The myelin vacuolation (mv) rat exhibits hypomyelination and vacuole formation in the myelin throughout the CNS, caused by a null mutation in the attractin gene. Myelin alterations in the spinal cord of mv rats progress during postnatal development and are more prominent in the white matter. In contrast, microglial ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.027
更新日期：2010-02-02 00:00:00
abstract：:Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs). EETs are produced by the cytochrome P450 (CYP) epoxygenase pathway of arachidonic acid (AA) metabolism and tend to be anti-hypertensive, anti-inflammatory and protective against isch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.060
更新日期：2009-09-29 00:00:00
abstract：:Aging leads to many changes in the circadian timekeeping system, including reduced sensitivity to phase-resetting signals such as systemic administration of the serotonergic agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). In previous studies, we observed an age-related decrease in 5-HT7 receptor binding s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.02.025
更新日期：2004-05-15 00:00:00
abstract：:The concentration of extracellular Ca2+ has been shown to enhance or attenuate [3H]acetylcholine (ACh) release subsequent to a conditioning stimulus in rat brain hippocampal slices. Slices were incubated in vitro in [3H]choline solution. Subsequently the slices were subjected to two consecutive electrical stimulations...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90261-7
更新日期：1987-09-08 00:00:00
abstract：:Postsynaptic potentials evoked in motoneurons innervating m. posterior biceps and semitendinosus (PBSt) and m. triceps surae (GS) by low threshold afferents from various tail muscles located at the level of the second-third caudal vertebrae were investigated in the non-anesthetized and spinalized cat. Afferent inputs ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00039-0
更新日期：1998-03-30 00:00:00
abstract：:Previous studies found that injection of the GABA uptake inhibitor nipecotic acid into the nucleus tractus solitarius (NTS) increases arterial pressure. This effect of nipecotic acid was not antagonized by the selective GABAA receptor blocking agent bicuculline, suggesting that the action of nipecotic acid was mediate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91227-8
更新日期：1990-09-03 00:00:00
abstract：:While exposure of cultured spinal neurons to mild hypothermia provides some protection from physical trauma (dendrotomy), profound cooling (< 17 degrees C) causes unrelated neuronal injury and death, which can be prevented by treatment with NMDA receptor antagonists. To investigate the mechanism of hypothermic neurona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00726-7
更新日期：1995-09-18 00:00:00
abstract：:Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03291-7
更新日期：2002-01-25 00:00:00
abstract：:Ongoing development of the dopamine system during adolescence may provide a partial mechanism for behavioral and psychiatric vulnerabilities. Despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. While...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.027
更新日期：2017-01-01 00:00:00
abstract：:The endocannabinoid system is a promising therapeutic target in a wide variety of diseases. However, the non-desirable psychotropic effects of natural and synthetic cannabinoids have largely counteracted their clinical usefulness. These effects are mostly mediated by cannabinoid receptors of the CB(1) type, that exhib...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.098
更新日期：2009-08-04 00:00:00
abstract：:Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02417-8
更新日期：2000-02-28 00:00:00
abstract：BACKGROUND:Toll-like receptor 4 (TLR4) is an important mediator of the innate immune response. It significantly contributes to neuroinflammation and may be involved in ischemic tolerance. It is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.005
更新日期：2011-04-12 00:00:00
abstract：:The beneficial effects of angiotensin II type 1 (AT1) receptor blockers (ARB) in cerebrovascular disease have been shown in clinical trials. However, the effects of ARBs vary based on their unique pharmacologic properties. In this study, we focused on telmisartan, a fat-soluble ARB with selective peroxisome proliferat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.101
更新日期：2010-06-22 00:00:00
abstract：:Gonadotrophin-releasing hormone (GnRH) neurons do not express the leptin receptor (OB-R) in the medial preoptic area (MPOA) and the medial basal hypothalamus (MBH). We assessed whether the effect of leptin on the secretion of luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) in proestrus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.001
更新日期：2015-04-16 00:00:00
abstract：:Movement of fragmented DNA in dendrites of retinal neurons during the apoptotic cell death was investigated. The time-course of the movement of fragmented DNA in dendrites of retinal neurons undergoing apoptotic cell death induced by intravitreal N-methyl-d-aspartate (NMDA) injection were examined by in situ terminal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.075
更新日期：2004-05-08 00:00:00
abstract：:The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil brain. The study aimed to explore three questions: (1) is the develop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.107
更新日期：2007-10-24 00:00:00
abstract：:The monovalent lithium ion inhibits the enzyme myo-inositol-1-phosphatase at concentrations comparable to those which are useful in the treatment of manic depressive illness. However, dialyzed cortical homogenates from rats which have been fed diets containing lithium carbonate demonstrate increased myo-inositol-1-pho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90245-3
更新日期：1986-08-20 00:00:00
abstract：:We tested the hypothesis that intravenous infusion of human marrow stromal cells (hMSC) with a nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl) aminio] diazen-1-ium-1,2-diolate (DETA/NONOate), enhances angiogenesis, neurogenesis and neurological functional recovery after stroke in rats compared to indivi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.080
更新日期：2004-04-16 00:00:00
abstract：:Response conflict can be induced by priming multiple responses competing for control of action in trials. The N2 is one functionally-related cognitive control index for response conflict. And yet the underlying whiter matter neural substrates of inter-individual difference in conflict N2 remain unclear. So the aim of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.008
更新日期：2017-12-01 00:00:00
abstract：:To date several circuities in supraspinal site of the central nervous system have been known to engage in pain modulation. Lateral hypothalamus (LH) is known as part of the circuit of pain modulation among supraspinal sites. Its role in several animal pain models has been well defined. In this study, we examined the r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146674
更新日期：2020-04-01 00:00:00
abstract：:Perineal muscles essential for copulatory functioning are innervated by Onuf's nucleus in humans and the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats. These structures sexually differentiate as a result of developmental androgen exposure in most species examined. The homologous st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.056
更新日期：2010-07-30 00:00:00
