Destruction of sympathetic and sensory neurons in the developing rat by a monoclonal antibody against the nerve growth factor (NGF) receptor.

abstract：:Saccadic eye tracking was studied in a monkey given i.v. injections of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The Parkinson-like symptoms which appeared in the animal's general motor behavior (akinesia, bradykinesia, hypokinesia) were also observed in its eye tracking. Similar oculomotor deficits are see...

journal_title：Brain research

authors： Brooks BA,Fuchs AF,Finocchio D

更新日期：1986-09-24 00:00:00

abstract：:The cellular origin and degree of collateralization of the subthalamostriatal, subthalamonigral and subthalamopallidal projections in the squirrel monkey (Saimiri sciureus) were studied using lectin-conjugated horseradish peroxidase (WGA-HRP), Nuclear yellow (NY) and Fast blue (FB) as retrograde tracers. In a first ex...

journal_title：Brain research

authors： Parent A,Smith Y

更新日期：1987-12-15 00:00:00

abstract：:The effects of brain and meningeal extracts from chick embryos on the proliferation of cultured neuroblasts from chick embryo cerebral hemispheres were studied. Morphological observations, counts of the cultured neurons, determination of DNA and protein contents as well as [3H]thymidine incorporation measurements were...

journal_title：Brain research

authors： Barakat I,Sensenbrenner M

更新日期：1981-06-01 00:00:00

abstract：:Antibodies to dopamine beta-hydroxylase (anti-D beta H) were taken up by noradrenergic nerve terminals in the iris following attachment to D beta H, and were transported back to, and accumulated in, the superior cervical ganglion (SCG). Concurrent, or prior destruction of noradrenergic terminals with 6-hydroxydopamine...

journal_title：Brain research

authors： Lees GJ,Horsburgh RJ

更新日期：1984-06-03 00:00:00

abstract：:The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. In the present study, we have investigated the effect of GABA on the elect...

journal_title：Brain research

authors： Louiset E,van de Put FH,Tonon MC,Basille C,Jenks BG,Vaudry H,Cazin L

更新日期：1990-05-28 00:00:00

abstract：:Metabolites formed from testosterone in the brain, their neuroanatomical distribution and the kinetic properties of the enzymes were studied in male and female Japanese quail chicks and compared with the adult brain using an in vitro radioassay. Oestradiol-17 beta. 5 alpha-dihydrotestosterone, 5 beta-dihydrotestostero...

journal_title：Brain research

authors： Hutchison JB,Schumacher M

更新日期：1986-02-01 00:00:00

abstract：:We have recently reported that the burst firing neurons are found in layer III as well as in layer V of cat sensorimotor cortex in vitro. In the present study, we examined the synaptic excitability of layer III neurons by white matter stimulation and compared with their firing patterns against the current injections t...

journal_title：Brain research

authors： Kitagawa H,Nishimura Y,Yamamoto T

更新日期：1999-09-18 00:00:00

abstract：:A sizeable, feedforward, GABAergic projection exists from the inferior colliculus to the medial geniculate body in cats. We compared the dimensions of GABA-immunoreactive and non-immunoreactive axons in the brachium of the cat inferior colliculus, and demonstrate that GABA-immunoreactive axons are among the largest of...

journal_title：Brain research

authors： Saint Marie RL,Stanforth DA,Jubelier EM

更新日期：1997-08-08 00:00:00

abstract：:We have recently reported the existence within chick embryo heart cell conditioned medium (HCM) of two distinct and independently assayable factors. One agent, ciliary neuronotrophic factor (CNTF), supports the in vitro survival of 8-day chick embryo ciliary ganglionic (CG) neurons. The other factor, polyornithine-att...

journal_title：Brain research

authors： Adler R,Manthorpe M,Skaper SD,Varon S

更新日期：1981-02-09 00:00:00

abstract：:To investigate the reversibility of neuronal functions during deep and mild hypothermia, we have examined changes in membrane properties of pyramidal neurons of the CA3 region of hippocampal slices during cooling and rewarming (8 approximately 37 degrees C) of the perfusion medium. Hypothermia reduced the excitatory p...

journal_title：Brain research

authors： Aihara H,Okada Y,Tamaki N

更新日期：2001-03-02 00:00:00

abstract：:The levels of PLCgamma, a phospholipase C (PLC) isozyme, were higher in the cytosol fraction than in the membrane fraction in several control brain regions. The levels of PLCgamma were significantly elevated in the membrane, but not in the cytosolic fraction of the hippocampus of AD subjects. In the superior and middl...

journal_title：Brain research

authors： Zhang D,Dhillon H,Prasad MR,Markesbery WR

更新日期：1998-11-16 00:00:00

abstract：:Responsiveness of single inferotemporal (IT) neurons to a tone as a start or warning signal in each test trial was investigated in monkeys performing visual discrimination of 4 patterns. It was found that the same IT neurons were responsive to both auditory signal and visual discriminanda with different response chara...

journal_title：Brain research

authors： Iwai E,Aihara T,Hikosaka K

更新日期：1987-04-28 00:00:00

abstract：:We previously reported that abdominal surgery induces Fos expression in specific hypothalamic and medullary nuclei and also causes gastric stasis. The gastric ileus is reduced by systemic capsaicin and abolished by central injection of corticotropin-releasing factor (CRF) antagonist. We studied the influence of system...

journal_title：Brain research

authors： Bonaz B,Taché Y

更新日期：1997-02-14 00:00:00

abstract：:Effects of lateral vestibular nucleus (LVN) stimulation on neuronal activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recordings in vivo. Stimulation of the contralateral LVN evoked 3 types of response in 46% (111/240...

journal_title：Brain research

authors： Katafuchi T,Puthuraya KP,Yoshimatsu H,Oomura Y

更新日期：1987-01-01 00:00:00

abstract：:The development of brain stem reticular core neurons in prenatally undernourished rats was investigated using the Golgi technique to determine the effect of immediate postnatal nutritional rehabilitation. Quantitative measurements of dendritic extent of branching and of cell size were compared in experimental and cont...

journal_title：Brain research

authors： Hammer RP Jr,van Marthens E

更新日期：1981-04-01 00:00:00

abstract：:Placental Opioid-Enhancing Factor (POEF) is a substance found in amniotic fluid (AF) that, when ingested, potentiates opioid-mediated, but not non-opioid-mediated, hypoalgesia. Vaginal-cervical stimulation (VCS) produces a stimulus-bound, partially opioid-mediated hypoalgesia that previous research has shown to be pot...

journal_title：Brain research

authors： Hoey RF,Hurley SW,Daniels D,Kristal MB

更新日期：2011-02-28 00:00:00

abstract：:Arachidonic acid metabolism in primary cultures of astroglial cells prepared from cerebra of rat embryos was examined. Arachidonic acid was mainly metabolized through the lipoxygenase pathway and the major metabolites formed were 12-hydroxyeicosatetraenoic acid (12-HETE), 11-HETE and 15-HETE. By contrast, in C6 cells,...

journal_title：Brain research

authors： Ishizaki Y,Morita I,Murota S

更新日期：1989-08-07 00:00:00

abstract：:In anaesthetized cats, medial gastrocnemius motor units (MUs) were stimulated with random sequences (mean rates between 6 and 12 pps) of electrical pulses delivered to their axons in small ventral root filaments. Muscle tension was recorded under isometric conditions, and spike trains of muscle spindle afferents were ...

journal_title：Brain research

authors： Christakos CN,Windhorst U

更新日期：1986-02-19 00:00:00

abstract：:The present study investigated differences between vestibulo-somatic and vestibulo-sympathetic reflexes, along with differences between somatic and autonomic spino-bulbo-spinal (SBS) reflexes in chloralose-urethane anesthetized cats. Electrical stimulation was applied to the vestibular nerve (V) for a duration of 0.3 ...

journal_title：Brain research

authors： Miyazawa T,Ishikawa T

更新日期：1985-05-20 00:00:00

abstract：:The role of mu opioid receptors in the nucleus raphe dorsalis (DR) in the control of apomorphine-induced aggression was studied in rats. Administration in the DR of a selective mu opioid receptor agonist, (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO), in doses ranging from 0.01 to 1 microgram/0.5 microliter, dose-depen...

journal_title：Brain research

authors： Giraud O,Cervo L,Grignaschi G,Samanin R

更新日期：1989-05-29 00:00:00

abstract：:A push-pull cannula supplied with artificial CSF was implanted in the striatum of anaesthetized rats, and the basal extracellular DA and DOPAC was assayed in the superfusates using HPLC and electrochemical detection. Simultaneously, a carbon fibre electrode was implanted in close proximity of the cannula and the evoke...

journal_title：Brain research

authors： Olivier V,Guibert B,Leviel V

更新日期：1995-10-09 00:00:00

abstract：:The mechanism of 3,4-methylenedioxymethamphetamine (d-MDMA)-induced neurotoxicity may involve formation of toxic radical species. Endogenous defenses against toxic radical species include tissue stores of vitamin E, and thiols. We examined whether vitamin E deficiency could alter d-MDMA-induced neurotoxicity by admini...

journal_title：Brain research

authors： Johnson EA,Shvedova AA,Kisin E,O'Callaghan JP,Kommineni C,Miller DB

更新日期：2002-04-19 00:00:00

abstract：:Opioid modulation of ingestion includes general opioid antagonism of deprivation-induced water intake and intake of sucrose and saccharin solutions. Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid...

journal_title：Brain research

authors： Beczkowska IW,Koch JE,Bostock ME,Leibowitz SF,Bodnar RJ

更新日期：1993-08-06 00:00:00

abstract：:The contribution of opioid receptors in the nucleus accumbens to contextual and auditory fear conditioning was examined. Impairment in contextual fear conditioning was found when training occurred under accumbal infusions of the opioid receptor agonist morphine in a dose-dependent and receptor specific fashion, only w...

journal_title：Brain research

authors： Iordanova MD,Haralambous T,McNally GP,Westbrook RF

更新日期：2013-06-23 00:00:00

abstract：:Propofol (2,6-diisopropylphenol) is an intravenous general anaesthetic which can directly activate and positively modulate the GABAA receptor. The effects of propofol on human recombinant GABAA receptors were studied in Xenopus oocytes expressing either alpha1beta2, alpha1beta2gamma2L, or alpha2beta2gamma2L receptor i...

journal_title：Brain research

authors： Lam DW,Reynolds JN

更新日期：1998-02-16 00:00:00

abstract：:There is evidence that acute exposure to kainic acid (KA) induces the release of endogenous ligands for opioid receptors and that mu-opioid agonists intensify KA-induced neurodegeneration. The aim of the present study was to investigate any acute toxic effects of KA upon mu-opioid receptors labelled with [3H]-DAMGO. 2...

journal_title：Brain research

authors： Ridd MJ,Fosbraey P,Kitchen I

更新日期：1998-12-14 00:00:00

abstract：:Two distinct families of low-molecular-weight toxins (argiotoxins) have been isolated from the venom of the orb-web spider. Argiope trifasciata. The toxins have been purified to homogeneity and characterised by spectroscopic, mass spectrometric and microchemical analysis. The major biologically active member of the fi...

journal_title：Brain research

authors： Budd T,Clinton P,Dell A,Duce IR,Johnson SJ,Quicke DL,Taylor GW,Usherwood PN,Usoh G

更新日期：1988-05-10 00:00:00

abstract：:Fluorescence resonance energy transfer (FRET) is a widely utilized optical technique for measuring small distances of 1-10 nm in live cells. In recent years, its application has been greatly popularized by the discovery of green fluorescent protein (GFP) and many improved variants which make good donor-acceptor fluoro...

journal_title：Brain research

authors： Takanishi CL,Bykova EA,Cheng W,Zheng J

更新日期：2006-05-26 00:00:00

abstract：:Rats with 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway show enhanced locomotor and stereotyped behaviors when challenged with direct and indirect dopamine (DA) agonists due to the development of postsynaptic supersensitivity. To determine if this phenomenon generalizes to other motor behaviors, we h...

journal_title：Brain research

authors： Meloni EG,Davis M

更新日期：2000-10-06 00:00:00

abstract：:An analysis of cellular kinetics during closure of the cranial neural folds in the C57BL mouse at 8 and 9 days gestations was obtained by means of tritiated thymidine autoradiography. At 8 days the short generation time (7.5 h) and high labeling index (61.4%) are evidence of intensive proliferative activity occurring ...

journal_title：Brain research

authors： Wilson DB

更新日期：1981-10-01 00:00:00