Abstract：
:The contribution of opioid receptors in the nucleus accumbens to contextual and auditory fear conditioning was examined. Impairment in contextual fear conditioning was found when training occurred under accumbal infusions of the opioid receptor agonist morphine in a dose-dependent and receptor specific fashion, only when shock onset coincided with auditory stimulus offset. Contextual fear conditioning was spared, however when the delivery of shock was not signalled by an auditory stimulus, the auditory stimulus was of low intensity (70dB), or an interval (10s or 30s) was interpolated between auditory stimulus offset and shock onset. These results provide evidence that opioid receptors in the nucleus accumbens regulate competition between contextual and discrete auditory stimuli for association formation.
journal_name
Brain Resjournal_title
Brain researchauthors
Iordanova MD,Haralambous T,McNally GP,Westbrook RFdoi
10.1016/j.brainres.2013.04.019subject
Has Abstractpub_date
2013-06-23 00:00:00pages
57-67eissn
0006-8993issn
1872-6240pii
S0006-8993(13)00532-5journal_volume
1517pub_type
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