Abstract:
:The mechanism of action of norepinephrine (NE)-induced potentiation of the population spike in the dentate gyrus of hippocampal slices was examined and compared with NE effects in field CA1. NE-induced potentiation was confined to the dentate gyrus, where slices perfused for 30 min with concentrations of NE as low as 5 microM exhibited potentiation of the perforant path evoked population spike. Potentiation began within 15 min, and lasted many hours after NE was washed out. Experiments where slices were pre-incubated with the protein synthesis inhibitor emetine indicated that there are two distinct phases to NE-induced potentiation. The initial short-term NE-induced potentiation (NEP) seen during NE application was not affected by a 30 min pre-incubation with emetine, whereas the long-lasting potentiation (NELLP) which persists after NE washout was completely blocked by emetine at a concentration which we have previously shown to be effective in blocking hippocampal long-term potentiation (LTP). Additional experiments indicated that both phases of NE-induced potentiation were completely blocked by the beta-antagonist propranolol and the beta 1-antagonist metoprolol. Furthermore, pre-incubation of slices with the direct-acting adenylate cyclase stimulant forskolin shifted the dose-response curves for both phases of NE-induced potentiation to the left. These results suggest that NE-induced potentiation is probably mediated by beta 1-receptor stimulation of adenylate cyclase. We have previously shown an importance for beta 1-receptor stimulation of adenylate cyclase in the production of LTP in the dentate. Thus, these results demonstrate a number of similarities between hippocampal LTP and NELLP in the dentate gyrus.
journal_name
Brain Resjournal_title
Brain researchauthors
Stanton PK,Sarvey JMdoi
10.1016/0006-8993(85)91299-5subject
Has Abstractpub_date
1985-12-30 00:00:00pages
276-83issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(85)91299-5journal_volume
361pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::A modified glyoxylic acid technique was used to examine central and peripheral nervous tissues in Aplysia californica. In addition to confirming the distribution of catecholamines and serotonin in the central nervous system, the method demonstrated the presence of monoamines in the opaline gland and bag cell clusters ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91081-8
更新日期:1983-01-17 00:00:00
abstract::To investigate whether tactile spatial attention is modulated by perceptual load, behavioural and electrophysiological measures were recorded during two spatial cuing tasks in which the difficulty of the target/non-target discrimination was varied (High and Low load tasks). Moreover, to study whether attentional modul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.08.007
更新日期:2017-10-15 00:00:00
abstract::Analgesia can be elicited following microinjections of morphine, mu-selective agonists and beta-endorphin into the amygdala. These analgesic responses are mediated by opioid synapses in the periaqueductal gray (PAG) since general (naltrexone), mu (beta-funaltrexamine) and delta2 (naltrindole isothiocyanate) opioid ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01115-3
更新日期:1998-01-01 00:00:00
abstract::Reward anticipation is associated with activity in the dopaminergic midbrain as well as the ventral striatum, amygdala, and medial prefrontal cortex. Dopaminergic neuromodulation declines with age, suggesting that incentive processing should also undergo age-related change. However, the literature is mixed, perhaps re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.063
更新日期:2015-07-01 00:00:00
abstract::In this study we examined the induction of heme oxygenase-1 (HO-1) in glia in the traumatized rat brain. HO-1 was immunolocalized in fixed sections of brain 3 h to 5 days after injury. Induction of this enzyme in astrocytes, microglia/macrophages, and oligodendrocytes was evaluated using immunofluorescent double label...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00680-4
更新日期:1996-10-14 00:00:00
abstract::The present study focuses on the myelination of rat septohippocampal fibres that are known to originate from GABAergic parvalbumin-containing, fast-firing, fast-conducting neurons and from cholinergic slow-firing, slow-conducting neurons. With the combined immunofluorescence for parvalbumin/myelin basic protein and ch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02653-6
更新日期:2000-09-29 00:00:00
abstract::Morphological alterations occurring in Schwann cells of unmyelinated fibers (unmyelinated Schwann cells) were investigated in the sciatic nerve of the twicher mouse, a murine model of human globoid cell leukodystrophy. After postnatal day 10, the number of Schwann cell-axon units gradually increased and the number of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91719-8
更新日期:1989-11-27 00:00:00
abstract::Convulsions were induced in young rats (1-21 days) with pentylenetetrazol or hyperthermia. As adults, these animals were kindled electrically in the basolateral or cortical amygdala, the hippocampus, or the pyriform cortex. Fewer amygdala stimulations were required to evoke major motor seizures in subjects treated at ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90168-3
更新日期:1985-10-01 00:00:00
abstract::Approximately 40-60% of BXSB mice have ectopic cell clusters in layer 1 of neocortex. Prior studies have shown distinct behavioral differences between those with ectopias and their non-ectopic littermates. In this study, female BXSB mice were reared after weaning in either enriched environments or standard cages. Foll...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-07-08 00:00:00
abstract::Fulfilled predictions lead to neural suppression akin to repetition suppression, but it is currently unclear if such effects generalize to broader stimulus categories in the absence of exact expectations. In particular, does expecting novelty alter the way novel stimuli are processed? In the present study, the effects...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.008
更新日期:2018-09-01 00:00:00
abstract::Amyloid deposition, a histopathological feature of Alzheimer's disease brain, may be the underlying cause of this disease. The isolation of enzymes involved in both the normal and aberrant or alternative processing of the beta-amyloid precursor protein may lead to an understanding of how beta-protein, the major compon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91279-n
更新日期:1992-09-04 00:00:00
abstract::Threohydroxyaspartate (THA)-induced glutamate excitotoxicity in organotypic culture of rat spinal cord is a well-known model of motor neuron degeneration. THA causes accumulation of synaptic glutamate and over stimulation of the postsynaptic receptor by inhibiting glutamate uptake. This model has also been used to ide...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.12.030
更新日期:2009-02-27 00:00:00
abstract::Embryonic day 15 rostral tectum (presumptive superior colliculus) was transplanted into the occipital cortex of newborn rats. One to two months later, the transplants were visualized and injected with either horseradish peroxidase (HRP) or wheat germ agglutinin conjugated with HRP (WGA/HRP). After the appropriate surv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90088-5
更新日期:1987-01-01 00:00:00
abstract::To characterize central nervous system changes that occur with anabolic steroid abuse in humans, immunocytochemical localization of androgen receptors in the brains of 10 intact and 10 castrated male rats was conducted after the administration of high levels of androgenic-anabolic steroids (AAS; 14 daily injections of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90823-6
更新日期:1993-09-17 00:00:00
abstract::Caprine beta-mannosidosis is an inherited lysosomal storage disorder due to a deficiency of beta-mannosidase which cleaves beta-linked mannose residues from the ends of N-asparagine linked oligosaccharides of glycoproteins. Histological and chemical examination has revealed a deficiency of compact myelin in the brains...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90278-u
更新日期:1993-08-20 00:00:00
abstract::Patients with sickle cell disease (SCD) can develop strokes and as a result, present neurologic and neurocognitive deficits. However, recent studies show that even without detectable cerebral parenchymal abnormalities on imaging studies, SCD patients can have significant cognitive and motor dysfunction, which can pres...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146968
更新日期:2020-11-01 00:00:00
abstract::Cerebral cortical blood flow (CBF) was measured autoradiographically in conscious mice without the monoamine oxidase B (MAOB) gene (KO, n=11) and the corresponding wild-type animals (WILD, n=11). Subgroups of animals of each genotype received a continuous intravenous infusion over 30 min of phenylethylamine (PEA), an ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01167-1
更新日期:1999-04-03 00:00:00
abstract::In nondiabetic animals, estrogen has been shown to provide significant neuroprotection in focal and transient forebrain ischemia models. However, that neuroprotection may be diminished or lost in the diabetic. In this study, we compared the level of brain damage in intact, ovariectomized (OVX) and 17beta-estradiol (E(...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03484-4
更新日期:2002-11-22 00:00:00
abstract::The effects of intracerebroventricular (i.c.v.) infusion of arginine vasopressin (AVP) on intracranial pressure (ICP), blood pressure (BP) and plasma AVP were investigated in conscious goats. The animals were implanted with ventricular (V) and cisternal (C) cannulae under halothane anaesthesia and allowed to recover p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90850-x
更新日期:1987-10-13 00:00:00
abstract::The glutamate analogue 2-amino-4-phosphonobutyric acid (AP4) is a potent antagonist at several synapses where an excitatory amino acid appears to be the neurotransmitter. Previous studies identified a Cl-/Ca2+ dependent [3H]glutamate binding site in synaptic plasma membrane (SPM) preparations that was also labeled by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90977-7
更新日期:1986-06-04 00:00:00
abstract::We have previously described a rodent model of brief (30 min) middle cerebral artery occlusion followed by reperfusion, in which infarction develops gradually, reaching completion more than 3 days after ischemia, accompanied by morphological, biochemical, and pharmacological evidence of apoptosis. In the present study...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02822-0
更新日期:2001-11-02 00:00:00
abstract::The present study gives a detailed description of the functional characteristics and of the topographic distribution of responses mediated through the climbing fiber (CF) pathway in the cerebellum of adult rats which have been repeatedly irradiated from birth so that the Purkinje cells (PCs) in the adult remained inne...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91291-1
更新日期:1987-09-22 00:00:00
abstract::Co-activation of group I metabotropic glutamate (mGlu) receptors and adenosine receptors resulted in an augmented cyclic AMP response in primary cultures of rat striatal neurones. L-glutamate and the selective group I agonist, (S)-dihydroxyphenylglycine (S-DHPG) evoked concentration-dependent potentiations of cyclic A...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00094-8
更新日期:1998-04-27 00:00:00
abstract::The effects of kindling induced in developing rat pups were re-examined when the rats reached maturity. Eighteen-day-old rats, implanted with bipolar electrodes, were separated into the following 4 groups: the fully kindled group consisted of pups that developed generalized convulsions; the partially kindled group of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90097-9
更新日期:1982-05-01 00:00:00
abstract::The visual system in the pigeon is composed of the tectofugal, thalamofugal and accessory optic pathways. Though their anatomy and physiology have been extensively studied, the functional interactions between these pathways are largely unknown. The present study shows by using multiple electrophysiological techniques ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.11.063
更新日期:2006-01-19 00:00:00
abstract::Most experimental spinal cord injury studies described to date have relied on a limited number of injury gradations, and have tacitly assumed that outcome (functional, histological, and/or neurophysiological) is a monotonically graded function of injury severity. In contrast, the present study provides evidence that f...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-08-05 00:00:00
abstract::A study was undertaken of the role of the external lateral parabrachial subnucleus (PBNLe) in flavor preferences induced by the intragastric administration of predigested/cephalic food. These preferences were developed using two different learning procedures, concurrent and sequential. In the concurrent procedure, two...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03032-9
更新日期:2002-09-20 00:00:00
abstract::The light green cells (LGCs) in the central nervous system of the pond snail Lymnaea stagnalis form a homogeneous group of neuroendocrine cells that are involved in the control of growth and metabolism. These cells are inhibited by dopamine and the neuropeptides APGWamide, FMRFamide and GGSLFRFamide. Thus, the LGCs fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01096-2
更新日期:1997-11-28 00:00:00
abstract::The retinohypothalamic tract, a monosynaptic retinal projection to the suprachiasmatic nucleus (SCN), is the path by which light entrains the circadian system to the external photoperiod. Serotonergic neurons in the mesencephalic median raphe nucleus (MnR) also give rise to a major SCN afferent projection. The present...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.02.083
更新日期:2005-05-17 00:00:00
abstract::The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. In the present study, we have investigated the effect of GABA on the elect...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91020-h
更新日期:1990-05-28 00:00:00