Abstract：
:Morphological alterations occurring in Schwann cells of unmyelinated fibers (unmyelinated Schwann cells) were investigated in the sciatic nerve of the twicher mouse, a murine model of human globoid cell leukodystrophy. After postnatal day 10, the number of Schwann cell-axon units gradually increased and the number of unmyelinated axons per unit progressively decreased in the twitcher mouse. However, the total number of unmyelinated axons showed no significant differences between twitcher and normal mice. Thus, these alterations of unmyelinated Schwann cells in the twitcher mouse suggest that attenuated branching of cellular processes develops at an early stage and progresses together with progression of demyelination in this mutant.
journal_name
Brain Resjournal_title
Brain researchauthors
Tanaka K,Nagara H,Kobayashi T,Goto I,Suzuki Kdoi
10.1016/0006-8993(89)91719-8subject
Has Abstractpub_date
1989-11-27 00:00:00pages
160-2issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)91719-8journal_volume
503pub_type
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