Abstract：
:Spontaneously firing units were recorded extracellularly from the hippocampus of anesthetized rats, and autocorrelograms were conventionally constructed. These conventional autocorrelograms were sorted into frequency-specific autocorrelograms according to the instantaneous firing frequency of the spike at Deltat=0, which was calculated based on the interval between the spike at Deltat=0 and the preceding spike. In this fashion, we found that autocorrelogram values were negatively correlated with instantaneous firing frequency during the 4-12 ms post-spike time period. The negative correlation during the 4-6 ms post-spike period could not have been due to the refractory period or GABAergic inhibition, and thus represented a third type of feedback regulation of spike firing completed within single neurons. Application of acetylcholine significantly enhanced this feedback regulation. Our 'autocorrelogram sorting' method thus proved to be successful in detecting cholinergically enhanced feedback regulation of spike firing intrinsic to single neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Murata M,Kato Ndoi
10.1016/j.brainres.2006.11.050subject
Has Abstractpub_date
2007-02-16 00:00:00pages
27-33issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)03422-6journal_volume
1133pub_type
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