Abstract：
:Arachidonic acid metabolism in primary cultures of astroglial cells prepared from cerebra of rat embryos was examined. Arachidonic acid was mainly metabolized through the lipoxygenase pathway and the major metabolites formed were 12-hydroxyeicosatetraenoic acid (12-HETE), 11-HETE and 15-HETE. By contrast, in C6 cells, which are considered to be of astroglial origin, arachidonic acid was mainly metabolized through the cyclooxygenase pathway and the major metabolites formed were prostaglandin (PG)E2, PGF2 alpha and thromboxane B2.
journal_name
Brain Resjournal_title
Brain researchauthors
Ishizaki Y,Morita I,Murota Sdoi
10.1016/0006-8993(89)90152-2subject
Has Abstractpub_date
1989-08-07 00:00:00pages
138-42issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90152-2journal_volume
494pub_type
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