The neurotoxicity of intrahippocampal kainic acid injection in rats is not accompanied by a reduction of Timm stain.

Abstract:

:Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectable loss of histologically demonstrable zinc as assessed by means of a modified Timm's sulphide-silver method. It is suggested that the selective injury of hippocampal neurons induced by kainic acid is not contingent on the release of zinc from mossy-fiber terminals.

journal_name

Brain Res

journal_title

Brain research

authors

Théorêt Y,Earnhardt TS,Bouldin TW,Krigman MR

doi

10.1016/0006-8993(88)91050-5

subject

Has Abstract

pub_date

1988-05-24 00:00:00

pages

341-6

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(88)91050-5

journal_volume

449

pub_type

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