Abstract:
:Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectable loss of histologically demonstrable zinc as assessed by means of a modified Timm's sulphide-silver method. It is suggested that the selective injury of hippocampal neurons induced by kainic acid is not contingent on the release of zinc from mossy-fiber terminals.
journal_name
Brain Resjournal_title
Brain researchauthors
Théorêt Y,Earnhardt TS,Bouldin TW,Krigman MRdoi
10.1016/0006-8993(88)91050-5subject
Has Abstractpub_date
1988-05-24 00:00:00pages
341-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(88)91050-5journal_volume
449pub_type
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