Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study.


:Sites which bind oxytocin and vasopressin with high affinity were detected in the brain and upper spinal cord of 12 human subjects, using in vitro light microscopic autoradiography. Tissue sections were incubated with tritiated vasopressin, tritiated oxytocin or an iodinated oxytocin antagonist. The ligand specificity of binding was assessed with unlabelled vasopressin or oxytocin in excess, as well as in competition experiments using synthetic structural analogues. The distribution of vasopressin binding sites differed markedly from that of oxytocin binding sites in the forebrain, while there was overlap in the brainstem. Vasopressin binding sites were detected in the dorsal part of the lateral septal nucleus, in midline nuclei and adjacent intralaminar nuclei of the thalamus, in the hilus of the dentate gyrus, the dorsolateral part of the basal amygdaloid nucleus and the brainstem. The distribution of oxytocin binding sites in the brainstem has been recently reported (Loup et al., 1989). Oxytocin binding sites were also observed in the basal nucleus of Meynert, the nucleus of the vertical limb of the diagonal band of Broca, the ventral part of the lateral septal nucleus, the preoptic/anterior hypothalamic area, the posterior hypothalamic area, and variably in the globus pallidus and ventral pallidum. The presence of oxytocin and vasopressin binding sites in limbic and autonomic areas suggests a neurotransmitter or neuromodulator role for these peptides in the human central nervous system. They may also affect cholinergic transmission in the basal forebrain and consequently play a role in Alzheimer's disease.


Brain Res


Brain research


Loup F,Tribollet E,Dubois-Dauphin M,Dreifuss JJ




Has Abstract


1991-08-02 00:00:00














  • Induction of c-fos expression in cervical spinal interneurons after kainate stimulation of the motor cortex in the rat.

    abstract::The expression of the immediate-early gene c-fos was used as a marker of neuronal activity to investigate the cervical spinal interneuron populations involved in the corticomotoneuronal pathway. Adult rats received unilateral kainate injections in the forelimb area of the primary motor cortex. After a survival period ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Curfs MH,Gribnau AA,Dederen PJ,Bergervoet-Vernooij IW

    更新日期:1996-06-24 00:00:00

  • Axonal transport of adenylate cyclase activity in normal and axotomized frog sciatic nerve.

    abstract::Adenylate cyclase activity accumulated proximal to a constriction placed around the frog sciatic nerve. The rate of accumulation was linear between 8 and 24 h following placement of the constriction; accumulation rate declined substantially after 24 h. Accumulation of activity distal to the constriction in normal nerv...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Carlsen RC

    更新日期:1982-01-28 00:00:00

  • Neurotrophin-3 and TrkC in the frog visual system: changes after axotomy.

    abstract::Neurotrophins are potent regulators of the survival of different neuronal populations in the CNS. Little is known of the immunodistribution of neurotrophin-3 (NT-3) and tyrosine kinase C (TrkC) receptor in the frog visual system, which can successfully regenerate and recover vision after injury. In this study we show ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Duprey-Díaz MV,Blagburn JM,Blanco RE

    更新日期:2003-08-22 00:00:00

  • Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.

    abstract::The stimulated (40 Hz) release of enkephalin from the myenteric plexus can be modulated by multiple types of opiate receptor. The direction of the modulation is not fixed but is bimodal. Both an inhibition and an enhancement of evoked release is observed depending on the concentration of opioid agonist that is used. E...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Xu H,Smolens I,Gintzler AR

    更新日期:1989-12-11 00:00:00

  • LPS-induced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus.

    abstract::The aim of this study was to examine the involvement of the hypothalamic oxytocin (OXT) and vasopressin (AVP) neurons in acute phase reaction using quantitative dual-labeled immunostaining with Fos and either OXT and AVP in several hypothalamic regions. Administration of low dose (5 microg/kg) and high dose (125 micro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Matsunaga W,Miyata S,Takamata A,Bun H,Nakashima T,Kiyohara T

    更新日期:2000-03-06 00:00:00

  • Augmentation of N-methyl-D-aspartate induced depolarizations by GABA in neocortical and archicortical neurons.

    abstract::The influence of the inhibitory transmitter gamma-aminobutyric acid (GABA) on depolarizations elicited by the excitatory amino acid N-methyl-D-aspartate (NMDA) was tested in neurons of organotypic neocortical tissue cultures (newborn rat) and in CA3 neurons of the hippocampal slice (guinea pig). Drugs were applied thr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Walden J,Speckmann EJ,Bingmann D,Straub H

    更新日期:1990-02-26 00:00:00

  • Role of neuron soma firing in the restoration of neurotensin store in sympathetic preganglionic neuron terminals after stimulus-evoked depletion.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Maher E,Bachoo B,Polosa C

    更新日期:1994-03-21 00:00:00

  • Changes in the metabolic profiles of the serum and putamen in Parkinson's disease patients - In vitro and in vivo NMR spectroscopy studies.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Toczylowska B,Zieminska E,Michałowska M,Chalimoniuk M,Fiszer U

    更新日期:2020-12-01 00:00:00

  • Transplants to the cerebral cortex of nucleus basalis magnocellularis-lesioned rats: effects on deficits in latent inhibition.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Welner SA,Rousse I,Rochford J

    更新日期:1995-02-13 00:00:00

  • Voltage-clamp analysis of halothane effects on GABA(A fast) and GABA(A slow) inhibitory currents.

    abstract::Voltage-clamped GABA(A fast) and GABA(A slow) inhibitory postsynaptic currents (IPSCs) were selectively elicited in hippocampal area CA1 pyramidal neurons. Clinically relevant concentrations of halothane (1.2 vol.%) prolonged both GABA(A fast) and GABA(A slow) IPSC decay times approximately 2.5 fold, while having litt...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lukatch HS,MacIver MB

    更新日期:1997-08-08 00:00:00

  • WITHDRAWN: Transplantation of bone mesenchymal stem cells containing the nerve growth factor gene in adult rat brain with Fimbria Fornix lesion.

    abstract::Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Leng SL,Fan WG,Qu HG,Xu SC,Zhong WY,Zhang WY,Zeng JQ,Long DH,He HW

    更新日期:2009-01-19 00:00:00

  • gamma-Aminobutyric acid, through GABAA receptors, inhibits the potassium-stimulated release of calcitonin gene-related peptide- but not that of substance P-like material from rat spinal cord slices.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bourgoin S,Pohl M,Benoliel JJ,Mauborgne A,Collin E,Hamon M,Cesselin F

    更新日期:1992-06-26 00:00:00

  • Histaminergic modulation of acoustically induced running behavior in rats.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vinogradova LV,Shatskova AB,Tuomisto L

    更新日期:2007-05-07 00:00:00

  • Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons.

    abstract::Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ciobanu C,Reid G,Babes A

    更新日期:2009-08-11 00:00:00

  • Voltage clamp analysis of ethanol effects on pacemaker currents of Aplysia neurons.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schwartz MH

    更新日期:1983-11-14 00:00:00

  • Effects of phencyclidine on 5-hydroxytryptophan- and suckling-induced prolactin release.

    abstract:UNLABELLED:The effects of acute and chronic exposure to phencyclidine (PCP) on the regulation of prolactin (PRL) secretion were examined. Female Sprague-Dawley rats were injected with PCP (10 mg/kg) or saline for 14 days, or just prior to the administration of the serotonin precursor, 5-hydroxytryptophan (5-HTP). A sin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hyde JF

    更新日期:1992-02-28 00:00:00

  • The effects of a reversible colchicine-induced lesion of the anterior ventral region of the third cerebral ventricle in rats.

    abstract::Colchicine was injected into the region of the organum vasculosum lamina terminalis/anterior region of the third cerebral ventricle (OVLT/AV3V) to produce a temporary disruption of the nervous connections of this area and the rest of the anterior hypothalamus, but to maintain the vascular connections intact. Rats were...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Thornton SN,Sirinathsinghji DJ,Delaney CE

    更新日期:1987-12-29 00:00:00

  • Auditory and visual neurons in the cat's superior colliculus selective for the direction of apparent motion stimuli.

    abstract::In the cat, cells of the superior colliculus (SC) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. Deep layer units of SC in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be muc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rauschecker JP,Harris LR

    更新日期:1989-06-19 00:00:00

  • Neural correlates of acoustic reasoning.

    abstract::We report an fMRI experiment on deductive reasoning with acoustically presented problems. Twelve volunteers received problems in which an acoustic stimulus came from the left or the right of another stimulus. The participants then heard a third stimulus coming from the left or the right of one of the proceeding stimul...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fangmeier T,Knauff M

    更新日期:2009-01-16 00:00:00

  • Shiverer jimpy double mutant mice. II. Morphological evidence supports reciprocal intergenic suppression.

    abstract::Mice which carry both the shiverer (shi) and the jimpy (jp) mutations have a morphological phenotype with features of each single mutation by itself but in milder form: the number of myelin sheaths is increased relative to jp, the thickness of sheaths and amount of major dense line is increased relative to shi, and th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Billings-Gagliardi S,Wolf MK,Kirschner DA,Kerner AL

    更新日期:1986-05-21 00:00:00

  • An MEG study of the spatiotemporal dynamics of bilingual verb generation.

    abstract::Studies of first (L1) and second (L2) language representation in the brain have not identified the timing and locations of neural regions involved in L1 and L2 processing. Magnetoencephalography offers high spatial and temporal resolution and can be employed to disentangle subtle timing and neural control differences ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pang EW,MacDonald MJ

    更新日期:2012-07-27 00:00:00

  • Effects of intraventricular substantia nigra allografts as a function of donor age.

    abstract::Transplantation of fetal substantia nigra into the brain can alleviate some of the manifestations of animal models of Parkinson's disease. The purpose of the present experiment was to determine the optimal embryonic donor age for solid tissue substantia nigra grafts. Rats with unilateral substantia nigra lesions were ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Simonds GR,Freed WJ

    更新日期:1990-10-15 00:00:00

  • Modulation of glycine-induced chloride current in acutely dissociated rat periaqueductal gray neurons by mu-opioid agonist DAGO.

    abstract::Effect of a mu-opioid agonist (D-Ala2,N-MePhe4,Gly5-ol-enkephalin, DAGO), on glycine (Gly)-induced chloride current (IGly) was investigated in the periaqueductal gray (PAG) neurons acutely dissociated 1-2-week-old Wistar rats by the use of nystatin-perforated patch recording configuration under voltage-clamp condition...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Min BI,Kim CJ,Rhee JS,Akaike N

    更新日期:1996-09-23 00:00:00

  • Colchicine-induced alterations in receptor-stimulated phosphoinositide hydrolysis in the rat hippocampus.

    abstract::Intradentate administration of colchicine has been reported to affect the cholinergic muscarinic system in the hippocampus, causing a reduction in quinclidinylbenzilate binding sites and an increase in choline acetyltransferase activity. Since the cholinergic muscarinic system is coupled to the formation of inositolph...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tandon P,Harry GJ,Tilson HA

    更新日期:1989-01-16 00:00:00

  • Dynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation.

    abstract::Recent developments in the understanding of the neurophysiological mechanisms underlying electroencephalographic (EEG) slow waves and sleep spindles imply an inverse relationship between these two EEG activities. The interrelationship between slow wave activity (0.75-4.5 Hz) and sleep-spindle activity (12-15 Hz) in el...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dijk DJ,Hayes B,Czeisler CA

    更新日期:1993-10-29 00:00:00

  • Peripheral input pathways projecting to the motor cortex in the cat.

    abstract::The possibility that the motor cortex receives peripheral input directly from the thalamus was examined using the evoked potential method and the following results were obtained. Potentials in the motor cortex evoked by stimulation of superficial radial (SR) or group II deep radial (DR) nerve were neither abolished no...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Asanuma H,Larsen KD,Zarzecki P

    更新日期:1979-08-24 00:00:00

  • PSA modification of NCAM supports the survival of injured retinal ganglion cells in adulthood.

    abstract::Neural cell adhesion molecule (NCAM) is known as the cell surface glycoprotein, and it belongs to the immunoglobulin superfamily of adhesion molecules. Polysialic acid (PSA) is a carbohydrate attached to NCAM via either of two specific sialyltransferases: ST8SiaII and ST8SiaIV. Polysialylated neural cell adhesion mole...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lobanovskaya N,Zharkovsky T,Jaako K,Jürgenson M,Aonurm-Helm A,Zharkovsky A

    更新日期:2015-11-02 00:00:00

  • Local sprouting of neurites from cultured PC12D cells in response to a concentration gradient of nerve growth factor.

    abstract::PC12D cells, a subline of PC12 cells, extend neurites very rapidly in response to NGF, even when RNA synthesis is blocked. Several minutes after the initiation of a concentration gradient of NGF from a micropipette in the vicinity of PC12D cells, clear projections emerged from cells on the side facing the micropipette...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sano M,Iwanaga M

    更新日期:1994-09-05 00:00:00

  • Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies.

    abstract::Experiments were conducted to examine sex differences in striatal dopamine function using in vivo microdialysis in freely moving rats. We report here a sex difference in basal extracellular striatal dopamine determined by quantitative microdialysis (the no net flux method) when castrated and ovariectomized rats were c...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Castner SA,Xiao L,Becker JB

    更新日期:1993-04-30 00:00:00

  • PhTx4, a new class of toxins from Phoneutria nigriventer spider venom, inhibits the glutamate uptake in rat brain synaptosomes.

    abstract::We report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using [(3)H]-L-glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC(50) value obtained was 2...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mafra RA,Figueiredo SG,Diniz CR,Cordeiro MN,Cruz JD,De Lima ME

    更新日期:1999-06-12 00:00:00