Glutamate excitation of oxytocin neurones in vitro involves predominantly non-NMDA receptors.

Abstract:

:Experiments were undertaken to compare effects of the NMDA and non-NMDA receptor antagonists, AP5 (40 microM) and NBQX (10 microM), on glutamate-induced firing in supraoptic oxytocin (OT) and vasopressin (VP) neurones in vitro. In putative OT neurones NBQX caused a significantly greater reduction in firing than AP5, whilst in putative VP neurones both antagonists reduced activity powerfully and to a similar extent. The relatively small effect of AP5 in putative OT neurones was unaffected by the removal of extracellular magnesium. These results suggest that glutamate-induced firing in putative OT neurones is predominantly controlled by non-NMDA receptors.

journal_name

Brain Res

journal_title

Brain research

authors

Richardson CM,Wakerley JB

doi

10.1016/s0006-8993(97)00728-2

subject

Has Abstract

pub_date

1997-08-29 00:00:00

pages

158-61

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(97)00728-2

journal_volume

767

pub_type

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