Abstract:
:Experiments were undertaken to compare effects of the NMDA and non-NMDA receptor antagonists, AP5 (40 microM) and NBQX (10 microM), on glutamate-induced firing in supraoptic oxytocin (OT) and vasopressin (VP) neurones in vitro. In putative OT neurones NBQX caused a significantly greater reduction in firing than AP5, whilst in putative VP neurones both antagonists reduced activity powerfully and to a similar extent. The relatively small effect of AP5 in putative OT neurones was unaffected by the removal of extracellular magnesium. These results suggest that glutamate-induced firing in putative OT neurones is predominantly controlled by non-NMDA receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Richardson CM,Wakerley JBdoi
10.1016/s0006-8993(97)00728-2subject
Has Abstractpub_date
1997-08-29 00:00:00pages
158-61issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00728-2journal_volume
767pub_type
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