Abstract：
:A normobar hypoxia (9% oxygen) of 8 h reduces the neurotoxicity of a subcutaneous injection of 10 mg/kg kainic acid given one week later. Both seizures and degenerative changes, including cell death of hippocampal and cortical neurons are markedly decreased by hypoxia. It is also shown that hypoxia also markedly reduced the extensive depletion of zinc from mossy fiber terminals normally induced by kainic acid. This suggests that a protective mechanism induced by hypoxia may affect the glutamatergic transmission in these synapses and prevent excessive synaptic excitation. The possible involvement of adenosine and/or GABA in this protective mechanism is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Pohle W,Rauca Cdoi
10.1016/0006-8993(94)91693-4subject
Has Abstractpub_date
1994-05-02 00:00:00pages
297-304issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91693-4journal_volume
644pub_type
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