Abstract:
:Adrenergic innervation of tibial and vagus nerves was studied after 1-16 weeks duration of streptozotocin (STZ)-induced diabetes in rats. Sucrose-phosphate glyoxylic acid (SPG) histochemistry and the formaldehyde-induced fluorescence (FIF) method were used to demonstrate adrenergic nerve fibers in the epi-perineurial and endoneurial compartments. Densities of innervation were quantitated with fluorescence microscopy. The density of periarteriolar adrenergic innervation in the epi-perineurium of the tibial and vagus nerves was increased 5 and 12 weeks after STZ injections as compared with control. At 16 weeks, mean densities of periarteriolar innervation in epi-perineurium had returned to or below control levels in both nerve types. In the endoneurium, however, the mean density of adrenergic nerve fibers decreased gradually at 5 weeks after induction of diabetes in both nerves, and was totally absent at 12 weeks. At 16 weeks no sign of recovering innervation in the endoneurium was seen. In conclusion, adrenergic innervation goes through similar pathological alterations both in tibial and vagus nerves shortly after the induction of streptozotocin diabetes. These changes may contribute to diabetic peripheral neuropathy by impairing the regulation of nerve blood flow.
journal_name
Brain Resjournal_title
Brain researchauthors
Koistinaho J,Wadhwani KC,Rapoport SIdoi
10.1016/0006-8993(90)91095-xsubject
Has Abstractpub_date
1990-04-09 00:00:00pages
106-12issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)91095-Xjournal_volume
513pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Pupil dilatation (PD) was produced by vaginocervical mechanical stimulation (VCMS) in intact rats, and in rats with spinal cord (SC) transection at level T7 (i.e., above the level of entry into SC of all genitospinal nerves). After transection of SC, bilateral vagotomy abolished PD in response to VCMS, providing evide...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.104
更新日期:2007-10-26 00:00:00
abstract::We examined the effect of the peripheral application of glutamate and capsaicin to the temporomandibular joint (TMJ) in influencing the activation and central sensitization of TMJ-responsive nociceptive neurons in the trigeminal subnucleus caudalis/upper cervical cord (Vc/UCC). The activity of single neurons activated...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.056
更新日期:2009-02-09 00:00:00
abstract::Synapses from Mauthner to giant fibers in the hatchetfish are chemically transmitting excitatory axo-axonic synapses located in the medulla. The synapses are 4--10 mum in diameter and easily identified for electron microscopy. Presynaptic vesicles are clustered near the contact regions and are round, clear and 40-60 n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90002-5
更新日期:1975-11-14 00:00:00
abstract::Endoplasmic reticulum (ER) and mitochondria dysfunction contribute to insulin resistance generation during obesity and diabetes. ER and mitochondria interact through Mitofusin 2 (MTF2), which anchors in the outer mitochondrial and ER membranes regulating energy metabolism. Ablation of MTF2 leads to ER stress activatio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.09.014
更新日期:2015-11-19 00:00:00
abstract::The effects of lesions in the pars compacta of the substantia nigra of 4-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were studied on (a) changes in blood pressure during a period of 6 weeks following lesioning, and (b) dopamine and metabolite concentrations in the caudate nu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91739-6
更新日期:1994-03-14 00:00:00
abstract::Recent research suggests that attributing human movement to ambiguous and static Rorschach stimuli (M responses) is associated with EEG mu suppression, and that disrupting the left inferior gyrus (LIFG; a putative area implicated in mirroring activity) decreases the tendency to see human movement when exposed to the R...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.12.007
更新日期:2018-02-01 00:00:00
abstract::Seventy-nine single units were recorded with glass micropipettes applied onto taste pores of the anterior portion of the tongue in anesthetized hamsters. The receptive field of each recorded unit was located by iontophoretic stimulation applying either anodal or cathodal current (1-20 microA) to a non-stimulating solu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90643-P
更新日期:1990-04-02 00:00:00
abstract::30-Day-old male Wistar rats were tested for acquisition and retention of operant conditioned behavior after bilateral subicular lesions made either electrolytically or chemically (ibotenic acid). The acquisition of operant learning was carried out in lesioned rats by assessing the number of sessions required to learn ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01135-3
更新日期:1997-01-16 00:00:00
abstract::Secondary hemorrhage after thrombolysis in ischemic stroke is an important complication, which has been difficult to study in preclinical disease models. We have established and characterized a model of thromboembolic middle cerebral artery occlusion in rats. Advantages of this model include a very low rate of spontan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.067
更新日期:2011-01-12 00:00:00
abstract::Previous studies suggested the existence of two populations of cells in the mammalian sympathetic nervous system which differ in their ability to express phenylethanolamine N-methyltransferase (PNMT), the enzyme which specifically subserves the biosynthesis of epinephrine: (1) sympathoblasts and their progeny, the nor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90163-9
更新日期:1984-04-01 00:00:00
abstract::During aging, estrogen production and circulating levels of estrogen are markedly decreased in females. Although several differences exist in the process of reproductive aging between women and female rats, the results of many studies suggest that the female rat, especially the middle-aged or aged ovariectomized femal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.11.010
更新日期:2014-01-16 00:00:00
abstract::The participation of glutamatergic circuits of the ventral basal ganglia in feeding-related regulatory mechanisms has been extensively indicated in primate and rodent species. In avian species, it has been shown that ICV injections of MK-801 or of CNQX increase food intake and reduce the latency of feeding initiation ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04196-3
更新日期:2003-03-14 00:00:00
abstract::The dopamine-releasing and depleting substance amphetamine (AMPH) can make cortical neurons susceptible to damage, and the prevention of hyperthermia, seizures and stroke is thought to block these effects. Here we report a 2-day AMPH treatment paradigm which affected only interneurons in three cortical regions with av...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03439-x
更新日期:2002-12-20 00:00:00
abstract::The hippocampal granule cells receive major inputs via the perforant path from other limbic structures such as the amygdala (AM). In this study, we examined Sprague-Dawley (SD) and Wistar rats, the effect of bilateral destructions of the hippocampal granule cells on the process of AM kindling and kindled AM seizures a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00574-a
更新日期:1995-09-11 00:00:00
abstract::Cannabinoids have neuroprotective effects that are exerted primarily through cannabinoid CB1 receptors in the brain. This study characterized CB1 receptor distribution in the double transgenic (dtg) APP(swe)/PS1(ΔE9) mouse model for Alzheimer's disease. Immunohistochemical labeling of CB1 protein in non-transgenic mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.12.061
更新日期:2011-02-28 00:00:00
abstract::This study investigates the reanalysis processes as a consequence of conflict between incompatible sentential representations in sentence comprehension. Using the event-related potential (ERP) technique, we examined the situation in which the sentential representation built upon world knowledge (i.e., the plausibility...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.090
更新日期:2008-04-08 00:00:00
abstract::Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CADASIL is caused by more than a hundred NOTCH3 mutations. Virtually all encoded mutant proteins contain an odd number of cysteines. As such, structural changes in NOTCH3 may be the primary molecular abnormality in CADASIL. Thus...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.08.018
更新日期:2014-10-02 00:00:00
abstract::Pentobarbital reversibly increased Na+-dependent GABA binding to bovine cerebral cortex membranes. This effect was chloride-dependent. Kinetic analysis of [3H]GABA binding revealed an increase of the apparent number of binding sites. Pretreatment of the membranes with Triton X-100 extremely diminished the effect of pe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90333-4
更新日期:1981-11-23 00:00:00
abstract::Endothelin (ET), a potent vasoconstrictor peptide, is believed to have central sites of action and potential neurohormonal effects relating to body fluid homeostasis and blood-pressure regulation. Systemic endothelin binds to receptors at circumventricular organs and has been shown to increase plasma concentrations of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90580-3
更新日期:1992-01-20 00:00:00
abstract::Growth of cultured N1E-115 neuroblastoma cells in 1 microM A23187 for 2 days to elevate internal Ca reduced both membrane Na current and the transient, but not steady state, component of outward K current. Na channel mRNA abundance was reduced by an average value of 45% without effect on Kv3.1. Increases in internal C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01340-7
更新日期:1996-01-15 00:00:00
abstract::Recently we have reported that methamphetamine (METH) neurotoxicity in rats depends on the environmental temperature. Here, we evaluate whether a cold environment (4 degrees C) or drugs which chloride and glutamate ion channel function block METH neurotoxicity in mice. Adult male CD mice received METH i.p. (4 x 10 mg/...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(09)90007-5
更新日期:1994-09-26 00:00:00
abstract::Inducible cyclooxygenase 2 (COX 2) converts arachidonic acid to prostaglandins, which are thought to mediate various peripheral lipopolysaccharide (LPS)-induced central effects, including generation of fever and activation of the hypothalamic-pituitary-adrenal axis. To localize prostaglandin production in the brain fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00402-8
更新日期:1998-08-17 00:00:00
abstract::The function of the phosphoinositide signal transduction system and the levels of heterotrimeric G-protein alpha-subunits were examined in postmortem prefrontal cortex regions (8/9) and region (10) from suicide victims with major depression and matched control subjects without psychiatric illness. The hydrolysis of [3...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00207-7
更新日期:1996-06-03 00:00:00
abstract::A study of brains of 16 dogs from one to 19 years of age showed a structure- and cell-type- specific pattern of tau protein phosphorylation at mAb Tau-1 site and the absence of phosphorylation at the mAb AT8 site. Strong immunolabeling with mAb Tau-1 of the mossy fibers and perikarya of neurons in sectors CA3 and CA4 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00542-3
更新日期:1998-08-17 00:00:00
abstract::Activation of the immune system in response to either infection or lipopolysaccharide (LPS) produces neurophysiological, neuroendocrine and behavioral changes. Some of the physiological consequences of LPS are mediated by endogenous opioid peptides. The following studies were designed to characterize the effects of LP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91908-9
更新日期:1994-06-13 00:00:00
abstract::MPTP is a neurotoxin thought to damage dopaminergic neurons through free radical formation. MPTP is metabolized in the brain to MPP(+), which is taken up into dopaminergic neurons via the dopamine transporter and assumed to impair mitochondrial function. We used striatal synaptosomes and telencephalic mitochondria to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02675-1
更新日期:2003-06-13 00:00:00
abstract::Distribution of adult T cell leukemia derived factor (ADF/TRX), a human thioredoxin homologue, was studied by immunohistochemistry in gerbil brain during reperfusion after transient cerebral ischemia. In control brains, immunoreactivity was observed widely in the central nervous system, including the ependyma, tanycyt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90130-f
更新日期:1993-10-15 00:00:00
abstract::The feedback effect of activity of area 21a on orientation maps of areas 17 and 18 was investigated in cats using intrinsic signal optical imaging. A spatial frequency-dependent decrease in response amplitude of orientation maps to grating stimuli was observed in areas 17 and 18 when area 21a was inactivated by local ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.024
更新日期:2004-02-20 00:00:00
abstract::Previous immunocytochemical, physiological, and molecular studies have reported that the Syrian hamster lacks a shortwave-sensitive (S) cone photopigment but retains circadian responses to ultraviolet (UV) light. Using opsin antibodies and a sensitive detection protocol, we here show that S opsin immunoreactivity colo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02267-9
更新日期:2002-03-01 00:00:00
abstract::The present experiments were designed to evaluate pharmacologically the role of three neuroanatomically related systems--dopamine, glutamate and GABA--in the motor-stimulant response to amphetamine and cocaine. The data indicate that stimulant-induced stereotypy is blocked by antagonists of all three systems and that ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01334-e
更新日期:1995-02-06 00:00:00