Abstract：
:Chronic intermittent hypoxia (CIH) may cause sustained systemic hypertension by increasing sympathetic neural discharge (SND). We hypothesized that CIH alters brainstem circuits modulating SND. After 30 days of CIH exposure in rats, increased c-fos labeling was seen in the nucleus of the solitary tract and ventrolateral medulla as well as other brainstem regions involved in regulation of SND. Increased expression of c-fos after CIH may indicate changes in neuronal genetic transcription which ultimately modulate SND.
journal_name
Brain Resjournal_title
Brain researchauthors
Greenberg HE,Sica AL,Scharf SM,Ruggiero DAdoi
10.1016/s0006-8993(98)01222-0subject
Has Abstractpub_date
1999-01-23 00:00:00pages
638-45issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01222-0journal_volume
816pub_type
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