The pattern of retinoic acid receptor expression and subcellular, anatomic and functional area translocation during the postnatal development of the rat cerebral cortex and white matter.

Abstract:

:Retinoic acid (RA), which is an important modulator of brain development, neural cell proliferation, neurite outgrowth, and synaptic plasticity, is regulated via changes in RA receptors. The pattern of RA receptor changes in the rat cerebral cortex and white matter during postnatal development has not been extensively studied. Therefore, we studied the mRNA expression patterns of 6 RA receptors in the postnatal rat cerebral cortex and white matter at 1, 3, 7, 10, 14, 21, 28, and 35days. We found that RARβ, RXRα and RXRβ mRNA levels gradually increased during postnatal development. RARα presented a nearly unimodal trend, but RARγ and RXRγ were generally bimodal. RARα, RARγ, and RXRγ mRNA levels peaked at postnatal day 21 (P21). The pattern of RARα expression was consistent with that of its mRNA levels. RARα and RXRγ mRNA levels were the highest among those of all RA receptors during postnatal development. Interestingly, RARα expression was mainly located in the cytoplasm in the postnatal development apart from P3d. We further showed that RARα is expressed mainly in layers 2 and 3, partly in layers 1 and 4, and in a limited manner in layers 5 and 6 in the parietal cortex. Most RARα expression occurs in layers 2, 3, and 4 in the temporal lobe cortex. We realized that the M1 S2 region of RARα is highly expressed and that the position of RARα changes dynamically to meet the needs of different regions during development. These results support the idea that the RA receptor plays an important role in the cerebrum during postnatal development and implementation of these functions may be mainly dependent on the non-transcriptional or post- transcriptional regulation.

journal_name

Brain Res

journal_title

Brain research

authors

Jiang W,Wen EY,Gong M,Shi Y,Chen L,Bi Y,Zhang Y,Liu YF,Chen J,Qu P,Liu YX,Wei XP,Li TY

doi

10.1016/j.brainres.2011.01.027

subject

Has Abstract

pub_date

2011-03-25 00:00:00

pages

77-87

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(11)00063-1

journal_volume

1382

pub_type

杂志文章
  • Changes in extracellular nitrite and nitrate levels after inhibition of glial metabolism with fluorocitrate.

    abstract::The role of glial cells in nitric oxide production in the cerebellum of conscious rats was investigated with a glial selective metabolic inhibitor, fluorocitrate. The levels of nitric oxide metabolites (nitrite plus nitrate) in the dialysate following in vivo microdialysis progressively increased to more than 2-fold t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00372-7

    authors: Yamada K,Senzaki K,Komori Y,Nikai T,Sugihara H,Nabeshima T

    更新日期:1997-07-11 00:00:00

  • Developmental immunohistochemistry of catalase in the human brain.

    abstract::The immunohistochemical studies on a peroxisomal enzyme, catalase, were done on brains from human fetuses to adults. The catalase-positive neurons appeared in the basal ganglia, thalamus and cerebellum at 27-28 weeks of gestation, and in the frontal cortex at 35 weeks. They then increased in number with gestational ag...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90314-l

    authors: Houdou S,Kuruta H,Hasegawa M,Konomi H,Takashima S,Suzuki Y,Hashimoto T

    更新日期:1991-08-16 00:00:00

  • Protection of nigral cell death by bilateral subthalamic nucleus stimulation.

    abstract::In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain do...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.08.082

    authors: Temel Y,Visser-Vandewalle V,Kaplan S,Kozan R,Daemen MA,Blokland A,Schmitz C,Steinbusch HW

    更新日期:2006-11-20 00:00:00

  • The effect of high-dose albumin therapy on local cerebral perfusion after transient focal cerebral ischemia in rats.

    abstract::We have shown that high-concentration albumin therapy is markedly neuroprotective in focal cerebral ischemia. The present study was conducted to ascertain the degree to which hemodynamic alterations are responsible for this therapeutic effect. Normothermic, physiologically regulated male Sprague-Dawley rats received a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00674-x

    authors: Huh PW,Belayev L,Zhao W,Busto R,Saul I,Ginsberg MD

    更新日期:1998-08-31 00:00:00

  • Motor experience with graspable objects reduces their implicit analysis in visual- and motor-related cortex.

    abstract::Motor-related regions of parietal and prefrontal cortices have been shown to selectively activate when observers passively view objects that afford manual grasping. Yet, it remains unknown whether these cortical responses depend on prior motor-related experience with the object being observed. To address this question...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.04.059

    authors: Handy TC,Tipper CM,Schaich Borg J,Grafton ST,Gazzaniga MS

    更新日期:2006-06-30 00:00:00

  • 3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner.

    abstract::The alpha7 nicotinic receptor agonist 3-[2,4-dimethoxybenzylidene]anabaseine (DMXB; GTS-21) was investigated for its ability to: (1) activate a variety of nicotinic receptor subtypes in Xenopus oocytes; (2) improve passive avoidance and spatial Morris water task performances in mecamylamine-sensitive manners in bilate...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00536-2

    authors: Meyer EM,Tay ET,Papke RL,Meyers C,Huang GL,de Fiebre CM

    更新日期:1997-09-12 00:00:00

  • An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.

    abstract::Stroke is the major cause of acquired epilepsy in the adult population. The mechanisms of ischemia-induced epileptogenesis are not completely understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis. The objective of this study was to develop an in vitro model of epileptogenesis in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.11.065

    authors: Ziobro JM,Deshpande LS,Delorenzo RJ

    更新日期:2011-01-31 00:00:00

  • Renormalization of regional brain blood flow during prolonged mild hypoxic exposure in rats.

    abstract::In this study, we measured regional brain blood flow (BF) in rats during hypoxic exposure. Our data show the hypoxia-induced brain blood flow increase returned to baseline within 1 week as blood hemoglobin increased. Because this return to baseline occurred before capillary angiogenesis, this result suggests that the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.08.046

    authors: Xu K,Puchowicz MA,LaManna JC

    更新日期:2004-11-19 00:00:00

  • The retinotectal projection of quarter eyes in Xenopus laevis.

    abstract::Following extirpation of three quarters of the eye anlage of Xenopus laevis in stage 33/34, the remaining quadrants developed into small eyes of normal shape. Irrespective of the different portions of the eye anlage the quarter eyes originated from, the retinotectal projection was always confined to the rostrolateral ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(86)90089-1

    authors: Degen N,Brändle K

    更新日期:1986-09-01 00:00:00

  • Neuron-specific mitochondrial degeneration induced by hyperammonemia and octanoic acidemia.

    abstract::The neuropathological consequences of acute exposure to the neurotoxicants ammonia and octanoic acid were investigated with the isolated, perfused canine brain preparation. After 1 h of combined hyperammonemia and octanoic acidemia, ultrastructural changes were apparent in all brain regions examined. The cell bodies o...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90916-3

    authors: Drewes LR,Leino RL

    更新日期:1985-08-12 00:00:00

  • Neurogenesis in spinal cord of mouse: an autoradiographic analysis.

    abstract::An autoradiographic analysis of the time and sites of origin, and the migration and settling patterns of neurons was made in the spinal cord of the mouse. The neurons originated on days 10--14 of gestation with temporal gradients along the ventrodorsal and rostrocaudal axes. The motor neurons originated on days 10 and...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90105-1

    authors: Nornes HO,Carry M

    更新日期:1978-12-22 00:00:00

  • Diffusion kurtosis imaging study on temporal lobe after nasopharyngeal carcinoma radiotherapy.

    abstract:PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.07.041

    authors: Wang D,Li YH,Fu J,Wang H

    更新日期:2016-10-01 00:00:00

  • Elevated concentrations of nerve growth factor in heart and mesenteric arteries of spontaneously hypertensive rats.

    abstract::Considerable evidence indicates an enhanced sympathetic innervation of muscular resistance arteries in the spontaneously hypertensive rat (SHR) compared with its normotensive Wistar-Kyoto (WKY) control. Since nerve growth factor (NGF) is known to affect the growth of sympathetic nerves, we have utilized a sensitive tw...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91012-h

    authors: Zettler C,Rush RA

    更新日期:1993-06-18 00:00:00

  • The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling, and kindling-induced potentiation in the perforant path of the unanesthetized rat.

    abstract::Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala. The present experiment sought to examine the relationship between synaptic potentiation of the perforant path-granule cell synapse and development of perforant...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90064-i

    authors: Gilbert ME,Mack CM

    更新日期:1990-06-11 00:00:00

  • Metabotropic glutamate receptor/phospholipase C system in female rat heart.

    abstract::Glutamate is the main excitatory neurotransmitter in the central nervous system. This amino acid mediates learning and memory processes acting through ionotropic and metabotropic receptor binding. Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that stimulate phospholipase C (PLC) or inhibit ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.01.010

    authors: Iglesias I,Castillo CA,León D,Ruíz MA,Albasanz JL,Martín M

    更新日期:2007-06-11 00:00:00

  • Decreased catalepsy response to haloperidol in the genetically dystonic (dt) rat.

    abstract::The rat mutant dystonic displays an autosomal recessive neurological disease characterized by slow, twisting movements of the limbs and trunk. Rats displaying clinical signs also show a decreased behavioral response to the dopaminergic blocker, haloperidol. Investigation of the development of the cataleptic response t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90920-x

    authors: McKeon TW,Lorden JF,Oltmans GA,Beales M,Walkley SU

    更新日期:1984-08-06 00:00:00

  • Dopamine attenuates the effects of GABA on single unit activity in the globus pallidus.

    abstract::Studies were conducted to assess whether stimulation of dopamine receptors located in the globus pallidus might play a role in mediating the enhanced pallidal activity seen after systemic administration of dopamine agonists or D-amphetamine. Dopamine, applied iontophoretically, had modest effects on the activity of pa...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90006-4

    authors: Bergstrom DA,Walters JR

    更新日期:1984-09-17 00:00:00

  • Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.

    abstract::A new compound, 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), has been evaluated as an excitatory amino acid receptor antagonist using electrophysiological assays and radioligand binding. In autoradiographic preparations, CPP reduces L-[3H]glutamate binding in regions of the hippocampus rich in N-m...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90128-9

    authors: Harris EW,Ganong AH,Monaghan DT,Watkins JC,Cotman CW

    更新日期:1986-09-10 00:00:00

  • Neuropeptide K enhances glucocorticoid release by acting directly on the rat adrenal gland: the possible involvement of zona medullaris.

    abstract::Neuropeptide K (NPK), a member of the kassinin-like tachykinin family, is contained in the rat hypothalamus and is known to stimulate pituitary ACTH release. The intraperitoneal bolus administration of NPK dose-dependently enhanced corticosterone blood level not only in intact rats, but also in hypophysectomized/ACTH ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91185-1

    authors: Mazzocchi G,Malendowicz LK,Andreis PG,Meneghelli V,Markowska A,Belloni AS,Nussdorfer GG

    更新日期:1994-10-24 00:00:00

  • Suprachiasmatic nucleus: role in circannual body mass and hibernation rhythms of ground squirrels.

    abstract::Female golden-mantled ground squirrels that sustained complete ablation of the suprachiasmatic nucleus (SCNx) were housed pre- and post-operatively at 23 degrees C and then at 6.5 degrees C for 5-7 yr. SCNx and control animals held at the higher temperature manifested circannual rhythms (CARs) in body mass. In contras...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01263-8

    authors: Ruby NF,Dark J,Heller HC,Zucker I

    更新日期:1998-01-26 00:00:00

  • Acetylcholine release from dissociated striatal cells.

    abstract::To study the regulation of striatal acetylcholine (ACH) release, adult male rat striata were dissociated and incubated with 3H-choline to synthesize 3H-ACH. Fractional 3H-ACH efflux per min during continuous perifusion was: (1) tightly regulated; (2) dependent on calcium influx; (3) stimulated by 10 mM K+ and 1 mM glu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00996-4

    authors: Login IS,Borland K,Harrison MB,Ragozzino ME,Gold PE

    更新日期:1995-10-30 00:00:00

  • A conditioned eyeblink obtained by using electrical stimulation of the facial nerve as the unconditioned stimulus.

    abstract::Cats acquired a conditioned eyeblink (CR) in a situation where the conditioned stimulus (CS) was a click and the unconditioned stimulus (US) was unilateral electrical stimulation of the zygomatic orbital branch of the facial nerve, which is a motor nerve. In a discrimitive training program, cats received both a click ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(75)90681-2

    authors: Black-Cleworth P,Woody CD,Niemann J

    更新日期:1975-06-06 00:00:00

  • Blocking of morphine-induced locomotor hyperactivity by amygdaloid lesions in C57BL/6 mice.

    abstract::Bilateral lesions of the amygdaloid complex in C57BL/6 mice prevented the occurrence of morphine-induced hypermotility (running fit). This effect, that was different from that observed after hippocampal lesions but similar to that observed after caudate lesions, confirms the role of the basal ganglia catecholaminergic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91328-0

    authors: Libri V,Ammassari-Teule M,Castellano C

    更新日期:1989-02-06 00:00:00

  • GFP-based FRET analysis in live cells.

    abstract::Fluorescence resonance energy transfer (FRET) is a widely utilized optical technique for measuring small distances of 1-10 nm in live cells. In recent years, its application has been greatly popularized by the discovery of green fluorescent protein (GFP) and many improved variants which make good donor-acceptor fluoro...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2006.01.119

    authors: Takanishi CL,Bykova EA,Cheng W,Zheng J

    更新日期:2006-05-26 00:00:00

  • Targeting RPTPσ with lentiviral shRNA promotes neurites outgrowth of cortical neurons and improves functional recovery in a rat spinal cord contusion model.

    abstract::After spinal cord injury (SCI), the rapidly upregulated chondroitin sulfate proteoglycans (CSPGs), the prominent chemical constituents and main repulsive factors of the glial scar, play an important role in the extremely limited ability to regenerate in adult mammals. Although many methods to overcome the inhibition h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.08.048

    authors: Zhou HX,Li XY,Li FY,Liu C,Liang ZP,Liu S,Zhang B,Wang TY,Chu TC,Lu L,Ning GZ,Kong XH,Feng SQ

    更新日期:2014-10-24 00:00:00

  • Myelin-associated glycoprotein (MAG) in myelin deficiency of caprine beta-mannosidosis.

    abstract::Caprine beta-mannosidosis is an inherited lysosomal storage disorder due to a deficiency of beta-mannosidase which cleaves beta-linked mannose residues from the ends of N-asparagine linked oligosaccharides of glycoproteins. Histological and chemical examination has revealed a deficiency of compact myelin in the brains...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90278-u

    authors: Sasaki M,Lovell KL,Möller JR

    更新日期:1993-08-20 00:00:00

  • Toll-like receptor 4 is involved in ischemic tolerance of postconditioning in hippocampus of tree shrews to thrombotic cerebral ischemia.

    abstract:BACKGROUND:Toll-like receptor 4 (TLR4) is an important mediator of the innate immune response. It significantly contributes to neuroinflammation and may be involved in ischemic tolerance. It is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.02.005

    authors: Feng R,Li S,Li F

    更新日期:2011-04-12 00:00:00

  • Calcitonin gene-related peptide and substance P immunoreactivity in the monkey trigeminal ganglion, an electron microscopic study.

    abstract::Calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity was examined in neurons of the monkey trigeminal ganglion. Moreover, CGRP- and SP-positive varicose nerve fibers were found, occasionally forming pericellular arborizations around trigeminal somata, which, at light microscopic level, suggeste...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91337-r

    authors: Prins M,van der Werf F,Baljet B,Otto JA

    更新日期:1993-12-03 00:00:00

  • Direct synaptic contacts of catecholamine axons on the preganglionic sympathetic neurons in the rat thoracic spinal cord.

    abstract::Preganglionic sympathetic neurons were labelled by retrograde transport of horseradish peroxidase, while catecholamine axon varicosities were marked by the uptake of 5-hydroxydopamine in the intermediolateral nucleus of the rat. The direct synaptic contacts from the catecholamine axons to the preganglionic sympathetic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90246-5

    authors: Chiba T,Masuko S

    更新日期:1986-08-20 00:00:00

  • Immunohistochemical demonstration of nitric oxide synthase in the peripheral autonomic nervous system.

    abstract::In the present immunohistochemical study the distribution of nitric oxide synthase (NOS) was studied in various autonomic ganglia and in related peripheral tissues of the rat. For comparison some other neuronal markers including acetylcholinesterase and tyrosine hydroxylase as well as several neuropeptides were analys...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91483-4

    authors: Ceccatelli S,Lundberg JM,Zhang X,Aman K,Hökfelt T

    更新日期:1994-09-12 00:00:00