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Pentazocine-like discriminative stimulus effects of morphine are blocked by the dopamine D-1 antagonist SCH23390, but not by the dopamine D-2 antagonist sulpiride.

Abstract：

:The effects of selective dopamine antagonists on the pentazocine-like discriminative stimulus effects of morphine were investigated in the rat trained to discriminate 3.0 mg/kg of pentazocine from vehicle. Morphine (3.0 mg/kg), a mu-selective agonist, produced stimulus effects in common with pentazocine (3.0 mg/kg), indicating that the stimulus effects are mediated through mu opioid receptors. The pentazocine-like stimulus effects of morphine (3.0 mg/kg) were clearly inhibited by the dopamine D-1 antagonist SCH23390 (0.03-0.56 mg/kg) but not by the dopamine D-2 antagonist sulpiride (20.0-80.0 mg/kg). The results suggest that the pentazocine-like discriminative stimulus effects of morphine are mediated via dopamine D-1 receptors.

journal_name

Brain Res

journal_title

Brain research

authors

Ukai M,Hiraiwa E,Kameyama T

doi

10.1016/0006-8993(91)91088-i

subject

Has Abstract

pub_date

1991-02-08 00:00:00

pages

146-8

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)91088-I

journal_volume

541

pub_type

杂志文章

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