Postsynaptic effects of DMSO at the frog neuromuscular junction.

Abstract:

:Postsynaptic effects of dimethylsulfoxide (DMSO) were studied at the frog cutaneous pectoris neuromuscular junction using electrophysiological techniques and computer assisted analysis. It was found that the average amplitude of extracellularly recorded miniature end-plate potentials (meppse) as well as the time constant of their monoexponential decay (tau) were both elevated in the presence of DMSO. In spite of increased scatter of individual values, amplitude and tau of meppse highly correlated with each other. These results imply that DMSO partially blocked the activity of acetylcholine esterase in addition to its already known presynaptic action of acetylcholine release enhancement. Inhibitory action of DMSO on activity of isolated acetylcholine esterase was previously demonstrated by biochemical methods.

journal_name

Brain Res

journal_title

Brain research

authors

Cherki-Vakil R,Meiri H

doi

10.1016/0006-8993(91)91719-h

subject

Has Abstract

pub_date

1991-12-06 00:00:00

pages

329-32

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)91719-H

journal_volume

566

pub_type

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