Abstract：
:Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhang RX,Liu B,Lao L,Qiao JT,Ruda MAdoi
10.1016/j.brainres.2005.01.039subject
Has Abstractpub_date
2005-03-21 00:00:00pages
238-42issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)00107-1journal_volume
1038pub_type
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