Abstract:
:Somatostatin receptors have been identified in different brain areas but the characterization of their postreceptor effect is still lacking. In this study we analyze the somatostatin effect on adenylate cyclase activity in different brain regions, namely frontal cortex, striatum, hypothalamus and hippocampus. Somatostatin inhibited basal adenylate cyclase activity in all brain areas, being maximally effective in the frontal cortex (-42%). Moreover, somatostatin inhibited both dopamine- and norepinephrine-stimulated adenylate cyclase activity in the examined cerebral regions showing a higher effectiveness than in basal conditions. VIP stimulation of adenylate cyclase was also reduced by somatostatin. The peptide inhibited by 50% forskolin-stimulated (10 nM to 10 microM) enzyme activity in frontal cortex and hypothalamus (in hippocampus the inhibition reached only -25%) showing a non-competitive pattern of inhibition. Finally, pertussis toxin pretreatment abolished the somatostatin inhibition of forskolin-stimulated frontal cortex adenylate cyclase activity. These results show that brain somatostatin receptors are coupled in an inhibitory way with adenylate cyclase enzyme that may represent one of the postreceptor mechanisms mediating the somatostatin modulation of brain functions.
journal_name
Brain Resjournal_title
Brain researchauthors
Schettini G,Florio T,Meucci O,Landolfi E,Grimaldi M,Ventra C,Marino Adoi
10.1016/0006-8993(89)90889-5subject
Has Abstractpub_date
1989-07-17 00:00:00pages
65-71issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90889-5journal_volume
492pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::alpha-Bungarotoxin (alpha-BuTX) binds in a saturable and practically irreversible fashion to membrane-associated receptors in the ciliary ganglion of the adult chick. The binding of toxin to receptors is competitively inhibited by nicotinic cholinergic ligands, and for these properties the receptors are regarded as ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)91130-7
更新日期:1978-09-15 00:00:00
abstract::30-Day-old male Wistar rats were tested for acquisition and retention of operant conditioned behavior after bilateral subicular lesions made either electrolytically or chemically (ibotenic acid). The acquisition of operant learning was carried out in lesioned rats by assessing the number of sessions required to learn ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01135-3
更新日期:1997-01-16 00:00:00
abstract::Vascular dysfunction is important in the pathogenesis of peripheral complications of diabetes. However, the effects of diabetes on cerebral blood flow and the role of vascular deficits in the pathogenesis of diabetic encephalopathy are still unknown. The present study examined whether experimental diabetes is associat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04211-7
更新日期:2003-03-21 00:00:00
abstract::This study evaluated the hypothesis that the dorsal motor nucleus (DMN) of the brainstem may mediate the ulcerogenic and acid-stimulatory effects of thyrotropin-releasing hormone (TRH) in rats. To accomplish this, intra-DMN microinjections of TRH (50 and 500 ng) were performed and their effects on acid secretion and g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90295-8
更新日期:1988-08-30 00:00:00
abstract::We have investigated the receptor subtype(s) mediating the noradrenergic inhibition of cerebellar Purkinje cell spontaneous firing rate using local application of specific agonists and antagonists, in situ, via pressure microejection. Extracellular action potentials were recorded from Purkinje neurons in anesthetized ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90552-5
更新日期:1988-10-18 00:00:00
abstract::The aim of this study was to evaluate spatial organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1), and to clarify the involvement in mechanisms underlying orofacial secondary hyperalgesia following infraorbital nerve injury. We found that the h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.02.023
更新日期:2012-04-27 00:00:00
abstract::The neurite promoting factors in the astroglial conditioned medium (As-CM) were characterized by using primary cultures of embryonic rat neocortical neurons. The factors in the As-CM bind to lectins such as wheat germ agglutinin (WGA), suggesting that they contain sugar moieties. When the WGA-bound fractions were appl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91059-p
更新日期:1990-09-10 00:00:00
abstract::Previous studies from our laboratory suggest that apolipoprotein (apoE), a lipid transporting protein, facilitates olfactory nerve regeneration. We have shown that apoE is enriched in the olfactory nerve and around the glomeruli of the olfactory bulb (OB). The studies reported herein were undertaken to identify possib...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.12.036
更新日期:2007-03-16 00:00:00
abstract::Tubulin immunostaining of semi-thin sections after polyethylene glycol embedding was used in the tectal plate of the embryonic mouse at 10 days postmating to analyze the effects of cold treatment on the microtubules of the different cell types seen at this stage. Three sets of microtubules are observed. In the radiall...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90021-6
更新日期:1987-12-01 00:00:00
abstract::The properties of 5 beta-reductase, 5 alpha-reductase and aromatase, 3 testosterone metabolizing enzymes, were studied in the quail brain by an in vitro incubation technique. The results describe the changes in time of metabolite production and the effects of temperature, enzyme and cofactor concentrations. The appare...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91118-1
更新日期:1984-07-02 00:00:00
abstract::Rats were trained on a radial maze and then given electrolytic lesions of the MS followed by a single intraseptal injection of 5 micrograms of NGF. Three days later they were re-tested on the maze. They were also post-operatively tested for hyperemotionality. MS lesions severely impaired performance on the radial maze...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00242-i
更新日期:1995-05-08 00:00:00
abstract::Corticosteroids exert important effects on brain function via glucocorticoid (GRs) and mineralocorticoid receptors (MRs) by inducing receptor translocation to the nucleus, where the receptor-ligand complexes modulate transcription of target genes. Based on studies describing uneven receptor expression patterns, region...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.048
更新日期:2009-01-16 00:00:00
abstract::The ability of the rat sciatic nerve to regenerate into a previously frozen distal nerve segment was studied and compared to regeneration after a crush lesion. The regeneration rate in the frozen segment was 1.9 mm/day, which was approximately half of that observed after a crush lesion (3.3 mm/day). If an unfrozen ner...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90161-8
更新日期:1988-06-21 00:00:00
abstract::Cortical Spreading Depression (CSD) is a well-studied model of preconditioning that provides a high degree of tolerance to a subsequent ischemic event in the brain. The present study was undertaken in order to determine whether the release of ATP during CSD could contribute to the induction of ischemic tolerance. Dire...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.070
更新日期:2007-09-07 00:00:00
abstract::The extraction and utilization of sound level changes in acoustic-autonomic reflex systems were studied on a vasoconstriction response in the tail of nonanesthetized rats. The vasoconstriction was found to depend on sound level and changes of level in the following ways. (a) It increased as a linear function of sound ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90555-7
更新日期:1980-04-21 00:00:00
abstract::Adaptive behaviour requires that organisms continuously monitor the environment for potentially significant information and evaluate whether currently unattended stimuli afford a behavioural change. Here we used event-related functional magnetic resonance imaging in humans to assess the neural mechanisms underlying th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.06.056
更新日期:2010-09-10 00:00:00
abstract::Spontaneous and hypothalamically induced hippocampal rhythmical slow activity (RSA or theta) was studied acutely in rats anaesthetized with urethane or immobilized with D-tubocurarine. Systematic tracking of microelectrodes showed two foci of hippocampal RSA, one located in the basal part (stratum oriens) of CAl (mean...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90711-3
更新日期:1976-12-17 00:00:00
abstract::The lamination of the hippocampus in the homozygous B6CBA weaver mouse (wv/wv) was compared with that in normal B6CBA littermates (+/+) and C57BL/6J mice using Nissl and Timm's staining. In Nissl-stained preparations, the normal littermates exhibit a compact, regular arrangement of pyramidal cells in area CA3 of the h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00974-u
更新日期:1995-10-23 00:00:00
abstract::The periodicity of the myelin sheath in glutaraldehyde carbohydrazide (GACH) embedded tissues from three 10-day-old and two 43-day-old mice was investigated with the electron microscope. The mean repeat period and number of repeats per fiber was measured in 31-89 fibers in the trapezoid bodies, olfactory tract and sci...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90051-2
更新日期:1976-09-03 00:00:00
abstract::In animal models, the hallmark of a hypoxic condition is a strong negative shift of the DC potential (anoxic terminal negativity, ATN). This DC-shift is interpreted to be primarily due to a breakdown of the membrane potential of neurons. Such massive neuronal depolarizations have not been reported for all human neocor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00911-0
更新日期:1996-11-25 00:00:00
abstract::Propofol (2,6-diisopropylphenol) is an intravenous general anaesthetic which can directly activate and positively modulate the GABAA receptor. The effects of propofol on human recombinant GABAA receptors were studied in Xenopus oocytes expressing either alpha1beta2, alpha1beta2gamma2L, or alpha2beta2gamma2L receptor i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01334-6
更新日期:1998-02-16 00:00:00
abstract::To evaluate the role of the amygdala in pain modulation and opioid-mediated antinociception, a recombinant, replication-defective herpes virus carrying the human preproenkephalin cDNA was injected bilaterally into the rat amygdala. Four days after gene delivery nociceptive behavior was assessed by the formalin test. R...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00194-2
更新日期:1998-05-04 00:00:00
abstract::The existence of monosynaptic contacts between primary afferents and motoneurons in the lumbar spinal cord of the turtle Pseudemys scripta elegans was demonstrated by intracellular injections of horseradish peroxidase. Three afferent-motoneuron combinations were satisfactorily labeled and revealed 1, 4 and 6 contacts ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90633-x
更新日期:1985-07-22 00:00:00
abstract::Triiodothyronine (T3) plays an important role during development of the central nervous system. T3 effects on gene expression are determined in part by the type of thyroid hormone receptors (TRs) expressed in a given cell type. Previous studies have demonstrated that thyrotropin releasing hormone (TRH) transcription i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.042
更新日期:2009-12-11 00:00:00
abstract::In non-neuronal cultures of cells dissociated from postnatal rat cerebellum astrocytes, identified by the presence of the marker protein glial fibrillary acidic protein (GFAP), displayed two distinct morphological forms. One class was stellate in shape with radially distributed fine processes, while the other class wa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90143-8
更新日期:1983-11-01 00:00:00
abstract::The anteroventral subdivision of the medial amygdala (MeAV) is one of the vomeronasal structures involved in the control of hormonally dependent behaviors such as sexual and agonistic behaviors in rats. The present study investigates some anatomical and neurochemical parameters of this nucleus (volume, number of neuro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.02.073
更新日期:2007-05-30 00:00:00
abstract::Increased alcohol consumption and heightened aggression have been linked to social isolation. Furthermore, animals treated with alcohol following social separation showed higher aggression together with lower serotonin transmission. Although reduced serotonin transmission in the brain may be related to alcohol-induced...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.02.007
更新日期:2017-05-01 00:00:00
abstract::Previous studies have indicated that amyloid precursor protein (APP) might be a trophic agent in the nervous system, possibly through the regulation of cell adhesion and the protease/protease inhibitor activity. Additionally, APP is upregulated during the development of the nervous system. In order to further study th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91329-d
更新日期:1992-10-16 00:00:00
abstract::Five complete poles of long nuclear chain intrafusal fibers of cat tenuissimus muscle spindles embedded in a plastic medium were cut in serial, 1 micron thick transverse sections and stained with toluidine blue. Each fiber pole displayed one plate-type motor ending positioned outside the encapsulated part of the spind...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91024-7
更新日期:1983-03-07 00:00:00
abstract::The growth inhibitory factor (GIF) is a new metallothionein (MT)-like protein that is downregulated in Alzheimer's disease (AD) brain. The biological function of GIF has not been fully clarified yet. We have raised an antibody to the synthetic polypeptide that is specific for rat GIF. The purified antibody reacted to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00522-r
更新日期:1995-08-07 00:00:00