Abstract：
:Quantitative autoradiography was used to analyze cholecystokinin receptor (CCK-R) binding in the ventromedial hypothalamic nucleus (VMH) of gonadectomized rats treated with estrogen or testosterone. In the rostral VMH, sex steroids did not affect binding levels. In the caudal VMH, in both gonadectomized male and female rats, the levels of CCK-R binding were decreased 24 h after injection of 50 micrograms of estrogen benzoate but were not changed after injection of 300 micrograms of testosterone propionate. We hypothesize that these changes in CCK-R binding in the VMH reflect ligand-induced down-regulation that result from an estrogen-facilitation of stimulated CCK release in the VMH.
journal_name
Brain Resjournal_title
Brain researchauthors
Popper P,Priest CA,Micevych PEdoi
10.1016/0006-8993(95)01561-2subject
Has Abstractpub_date
1996-03-18 00:00:00pages
335-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(95)01561-2journal_volume
712pub_type
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