Abstract：
:Depending on experimental conditions, chronic cocaine exposure can induce an increase in binding to the dopamine transporter (DAT). One possible mechanism for the cocaine-induced-upregulation in DAT binding sites is through stimulation of presynaptic D2 receptors by excess synaptic dopamine. To test this hypothesis, the present experiment examined in rats the effect of chronic quinpirole and apomorphine treatments on striatal DAT binding sites. Rats were chronically injected subcutaneously with either: quinpirole, 0.7 mg/kg body weight, apomorphine, 2.0 mg/kg body weight, or vehicle. Striatal DAT binding was then examined autoradiographically using the DAT-selective cocaine congeners [125I]RTI-121 and [3H]WIN 35428. Analysis of the results indicated that quinpirole and apomorphine administration did not alter DAT cocaine binding sites.
journal_name
Brain Resjournal_title
Brain researchauthors
Little KY,Gorebig J,Carroll FI,Mapili J,Meador-Woodruff JHdoi
10.1016/s0006-8993(96)01033-5subject
Has Abstractpub_date
1996-12-02 00:00:00pages
313-6issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(96)01033-5journal_volume
742pub_type
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