Abstract：
:The effects of ventromedial hypothalamic (VMH) stimulation on various metabolic parameters in freely moving animals were measured using a specific indirect calorimetric chamber associated with a quantitative measurement of locomotor activity, which allows the separate measurement of locomotor energy expenditure from that of background metabolism, BM (free from expenses due to locomotion). To obtain circumscribed VMH stimulation, a slight-intensity (20-25 microA) bipolar, constant current was applied for 15 min at the beginning of the dark phase on ad libitum fed rats. The VMH stimulation suppressed feeding for 40 min, then animals progressively recovered within the subsequent 60 min as shown by comparison with the control group. On different days, the same stimulation parameters were applied while food was unavailable, and metabolic parameters were recorded. An increase in BM lasting 30 min was observed. This increase in metabolic rate was sustained by means of a recruitment of lipid stores as indicated by a concomitant drop in respiratory quotient. These observations indicate that the VMH is part of the sympathetic nervous system, capable of inducing lipolysis. The sequence of metabolic and feeding events may then in part be due to VMH-induced lipolysis that provides more fuel to the metabolic economy, raising the BM, which in turn decreases hunger.
journal_name
Brain Resjournal_title
Brain researchauthors
Ruffin M,Nicolaidis Sdoi
10.1016/s0006-8993(99)01922-8subject
Has Abstractpub_date
1999-10-30 00:00:00pages
23-9issue
1eissn
0006-8993issn
1872-6240pii
S0006899399019228journal_volume
846pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Marmoset monkeys (Callithrix jacchus) with bilateral transections of the anterior temporal stem, amygdala and fornix were unable to relearn a 2-choice object discrimination first learnt prior to surgery, and were very severely impaired at relearning a concurrent object discrimination task which they had learnt and rel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02998-x
更新日期：2001-01-05 00:00:00
abstract：:The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.074
更新日期：2010-01-22 00:00:00
abstract：:Evidence is presented which suggests that central neural changes occur during the brief early phase after subcutaneous formalin injection that are essential for the expression of pain during the long-lasting (tonic) later phase. First, tonic pain responses to subcutaneous formalin injections are abolished only if the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91835-5
更新日期：1990-12-03 00:00:00
abstract：:These experiments examined the effects, on retention, of posttraining intra-amygdala administration of norepinephrine (NE), and propranolol. Rats were trained on a one-trial step-through inhibitory avoidance task and tested for retention 24 h later. Injections were administered bilaterally (1.0 microliter/injection) t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91049-8
更新日期：1986-03-12 00:00:00
abstract：:Carnosine is a compound of naturally-occurring dipeptide that synthesized by the carnosine synthetase from beta-alanine and l-histidine. Recent reports claim that carnosine plays an important role in the control of epilepsy but its involvement in anticonvulsant functions remains unknown. In this study, we investigated...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.08.019
更新日期：2008-11-06 00:00:00
abstract：:Intraocular injections of ethylcholine mustard aziridinium ion (AF64A) in the rat depressed retinal choline acetyltransferase (ChAT) activity in a dose-dependent manner without any significant change in the content of amino acid neurotransmitters GABA, glycine, aspartate and glutamate. ChAT reduction was already detec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91466-7
更新日期：1988-01-26 00:00:00
abstract：:Perinatal exposure to environmental tobacco smoke (ETS) has adverse effects on neurobehavioral development. In the current study, rats were exposed to ETS during gestation, during the early neonatal period, or both. Brains and hearts were examined for alterations in adenylyl cyclase (AC) activity and for changes in be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02145-x
更新日期：2001-04-13 00:00:00
abstract：:The neurobiology of autism spectrum disorders (ASDs) has become increasingly understood since the advent of magnetic resonance imaging (MRI). Initial observations of an above-average head circumference were supported by structural MRI studies that found evidence of increased total brain volume and early rapid brain ov...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2010.11.076
更新日期：2011-03-22 00:00:00
abstract：:Dantrolene sodium, a skeletal muscle relaxant, was investigated for its action on single motor units of the peroneus tertius muscle in cats anaesthetized with pentobarbitone sodium. Motor axons were isolated in ventral root filaments and their muscle units were identified as either fast-fatiguable (FF), fast-resistant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90631-5
更新日期：1983-02-21 00:00:00
abstract：:Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02526-5
更新日期：2003-05-30 00:00:00
abstract：:The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90300-4
更新日期：1989-10-23 00:00:00
abstract：:Mild footshock stress results in the metabolic activation of the prefrontal cortical dopamine (DA) innervation, but does not augment DA utilization in mesolimbic areas (such as the nucleus accumbens septi, NAS) or the striatum. However, increases in either the intensity or duration of footshock stress increase DA util...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91557-w
更新日期：1990-06-25 00:00:00
abstract：:We have investigated the receptor subtype(s) mediating the noradrenergic inhibition of cerebellar Purkinje cell spontaneous firing rate using local application of specific agonists and antagonists, in situ, via pressure microejection. Extracellular action potentials were recorded from Purkinje neurons in anesthetized ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90552-5
更新日期：1988-10-18 00:00:00
abstract：:Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Our laboratory has shown that infusion of human umbilical cord blood (HUCB) cells protects striatal white ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.078
更新日期：2010-12-17 00:00:00
abstract：:Recent evidence has suggested that cholecystokinin (CCK) may act as a physiological opiate antagonist. Both the overlap of CCK and opiate systems within the central nervous system and the fact that exogenous CCK can antagonize opiate analgesia suggest that endogenous CCK systems interact with opiate-mediated pain inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91511-2
更新日期：1985-02-18 00:00:00
abstract：:Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate, retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical cir...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02170-3
更新日期：2000-07-07 00:00:00
abstract：:The influence of emotion on cognition plays an important role in people's everyday life as well as in psychiatric and neurological disorders. The present study used fMRI to examine the neural correlates of cognitive-emotional interactions and its inter-individual differences. Twenty-one healthy males performed a 0-bac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.048
更新日期：2007-06-04 00:00:00
abstract：:Cingulate cortex (CC) unit responses to hippocampal volleys and afterdischarges were studied in 4 awake unsedated squirrel monkeys using extracellular microelectrodes. Stimuli were delivered via bipolar electrodes chronically implanted bilaterally in anterior and posterior hippocampus. A total of 412 units in 21 track...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91253-2
更新日期：1983-01-24 00:00:00
abstract：:It has been suggested that individual predisposition to develop amphetamine self-administration is associated with impairment in corticosteroid negative feedback mechanisms. Since corticosteroid receptors, particularly those in the hippocampus, are involved in corticosterone feedback sensitivity, we examined the relat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91137-p
更新日期：1991-05-10 00:00:00
abstract：:We examined the electrophysiological properties of cholinergic and non-cholinergic neurons in the medial septum-diagonal band complex (MSDB) of the rat in the in vitro slice preparation. Cells were identified electrophysiologically, filled with Lucifer yellow, fixed and processed for immunohistochemistry with fluoresc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91106-q
更新日期：1990-04-09 00:00:00
abstract：:Within 5 days after reduction of activity of the rat soleus muscle, there was remodelling of the neuromuscular junction. Post-synaptic clefts were shorter, wider, and flatter, whereas nerve terminals showed sprouting and longitudinal distortion. The results, which differ from those found after denervation or total dis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90039-9
更新日期：1986-09-24 00:00:00
abstract：:Previous studies have revealed that there are increases in the incorporation of [3H]amino acids into protein in the denervated neuropil of the dentate gyrus during periods of reactive synaptogenesis. The present study evaluates whether the increase in incorporation reflects an increase in protein synthetic machinery (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90032-5
更新日期：1987-09-01 00:00:00
abstract：:To understand the role of hypothalamic dopamine in thermoregulation, single unit activity was recorded in vitro, from constantly perfused tissue slices of rat preoptic area and anterior hypothalamus, PO/AH. The firing rate and thermosensitivity of individual PO/AH neurons were determined before, during and after tissu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90364-0
更新日期：1984-07-23 00:00:00
abstract：:Single unit discharges in the superior secondary gustatory nucleus of the carp, Cyprinus carpio L., were studied electrophysiologically in response to chemical stimulation of the external chemoreceptors of the facial skin surface. Of 36 gustatory neurons recorded, 80.6% were facilitated by taste stimuli and 19.4% were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90184-0
更新日期：1981-07-27 00:00:00
abstract：:A hypothalamic oxytocinergic-descending pathway that reaches the dorsal horn of the spinal cord has been well documented and recently related to states of pain and analgesia. In order to study the action of the neuropeptide oxytocin (OT) on pain-related responses, we compared dorsal horn neuronal responses to electric...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.03.020
更新日期：2005-05-31 00:00:00
abstract：:We have developed a serum-free chemically defined medium which allows the obtainment of a primary culture highly enriched in ciliated ependymal cells. Serum was never used. Mechanically dissociated neonatal rat brain hemisphere cells were seeded on a fibronectin substratum. Culture medium was minimum Eagle's medium un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(86)80228-1
更新日期：1986-03-01 00:00:00
abstract：:The distribution of bFGF in mouse and rat retinas was established using an antibody generated against a rat specific bFGF sequence. The patterns established with this antibody were distinctly different in comparison to the immunostaining patterns using antibodies prepared against similar regions of bovine and human bF...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91236-8
更新日期：1992-07-10 00:00:00
abstract：:Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP cause...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.040
更新日期：2015-11-02 00:00:00
abstract：:A 'new' and orderly representation of the body surface was found in the cerebral cortex of the cat. This somatotopic map was located in the anterior ectosylvian sulcus (AES), an area known to represent several modalities, but believed to be distinguished from primary sensory cortex by its lack of sensory topographies....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90207-4
更新日期：1982-03-04 00:00:00
abstract：:Intracellular recordings were made from Renshaw cells in the cat. Recurrent excitatory postsynaptic potentials (EPSPs) were elicited by antidromic stimulation of the ventral roots. These EPSPs had a simple monophasic time course without a spike-like peak reported by previous authors. No hyperpolarization could be dete...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90818-0
更新日期：1981-10-26 00:00:00
