Abstract：
:Dantrolene sodium, a skeletal muscle relaxant, was investigated for its action on single motor units of the peroneus tertius muscle in cats anaesthetized with pentobarbitone sodium. Motor axons were isolated in ventral root filaments and their muscle units were identified as either fast-fatiguable (FF), fast-resistant (FR), fast-intermediate (FI) or slow-resistant (S). Dantrolene sodium (2 mg/kg) was administered intravenously in a solution of 1,2-propanediol. Effects were observed on the twitches, unfused tetanic contractions and maximal tetanic tensions of 78 motor units in 5 experiments. Contractile tension was depressed whereas muscle action potentials appeared unaffected. Maximal tetani were less depressed than unfused tetani and twitches. The reduction of tension was more pronounced for fast (FF, FR and FI) than for slow units. After drug injection, the mean tensions developed at the end of a 3 s period of stimulation at 40/s were: 13.1%, 10.6% and 12.7% of pre-drug control for FF, FR and FI units, respectively, and 67.1% for S units. Upon prolonged stimulation at 40/s fast units depressed by Dantrolene sodium were able to potentiate back to their initial pre-drug tension.
journal_name
Brain Resjournal_title
Brain researchauthors
Jami L,Murthy KS,Petit J,Zytnicki Ddoi
10.1016/0006-8993(83)90631-5subject
Has Abstractpub_date
1983-02-21 00:00:00pages
285-94issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90631-5journal_volume
261pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:cAMP-dependent regulation of the steady-state mRNA levels for the ECM components, laminin A, B1 and B2 chains, collagen types I, III and IV were examined by Northern blot analysis in cultured rat Schwann cells. ECM mRNAs of laminin B1 chain and collagen types I and IV were expressed at high levels in the control Schwa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90409-x
更新日期：1994-08-08 00:00:00
abstract：:Physical exercise is likely to alter brain function and to afford neuroprotection in several neurological diseases. Although the favorable effects of physical exercise on traumatic brain injury (TBI) patients is well known, little information is available regarding the role of free radicals in the improvement induced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.04.052
更新日期：2009-07-07 00:00:00
abstract：:The mechanisms responsible for the rate of rise (RR) of cumulative depolarization induced by dorsal root stimulus trains were investigated with intracellular recordings from motoneurones of the rat isolated spinal cord. The NMDA receptor antagonists CPP or APV depressed the cumulative depolarization but not its RR whi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00997-3
更新日期：1996-11-04 00:00:00
abstract：:We examined the role of the phosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) and cyclic AMP-response element binding protein (CREB) in N-methyl-d-aspartate (NMDA)-induced neurotoxicity in the rat retina. Western blot analysis showed early elevation of phosphorylated CaMKII (p-CaMKII) protein ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.055
更新日期：2007-12-12 00:00:00
abstract：:Ion channels are integral membrane proteins that allow passive diffusion of ions across membranes. In neurons and in other excitable cells, the harmonious coordination between the numerous types of ion channels shape and propagate electrical signals. Increased accumulation of reactive oxidative species (ROS), and subs...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.02.046
更新日期：2016-05-15 00:00:00
abstract：:The treatment of acute and chronic pain is still deficient. The modulation of glial cells may provide novel targets to treat pain. We hypothesize that astrocytes and microglia participate in the initiation and maintenance of both, acute surgical and chronic neuropathic pain. Rats underwent paw incision, L5 nerve expos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.004
更新日期：2008-07-11 00:00:00
abstract：:Anticonvulsant mood stabilizers, e.g., valproic acid and carbamazepine, and atypical antipsychotic drugs (APDs), e.g., clozapine, quetiapine, olanzapine, risperidone, and ziprasidone, have been reported to preferentially increase dopamine (DA) release in rat medial prefrontal cortex (mPFC), an effect partially or full...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.005
更新日期：2005-07-12 00:00:00
abstract：:We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-d-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/macrophage activation. The excitotoxic lesion both damaged oligodendrocy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.007
更新日期：2010-05-06 00:00:00
abstract：:Intracerebroventricular (i.c.v.) infusion of sodium in rats increases cerebrospinal fluid (CSF) [Na], mimicking the effects of a high salt diet in salt-sensitive strains and causing sympathetic hyperactivity and a pressor response that are mediated via both an endogenous brain ouabainlike substance (OLS) and the brain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.056
更新日期：2004-09-24 00:00:00
abstract：:Amyloid beta-protein (A beta) is the major protein of cerebrovascular and plaque amyloid in Alzheimer's disease (AD). Extensive evidence has demonstrated abnormal protein phosphorylation in this disease. We investigated the effect of synthetic A beta with the amino-acid sequence corresponding to cerebrovascular A beta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90479-7
更新日期：1993-11-26 00:00:00
abstract：:Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO concentration in migraineurs have not yet been identified, although, animal models highlight cortical spreading depression (CSD) as a potential candidate. These studies have focused on CSD-associa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03191-7
更新日期：2001-02-09 00:00:00
abstract：:Little is known about the movement of 5-aminolevulinic acid (delta-aminolevulinic acid; ALA) between blood and brain. This is despite the fact that increases in brain ALA may be involved in generating the neuropsychiatric symptoms in porphyrias and that systemic administration of ALA is currently being used to delinea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03749-6
更新日期：2003-01-10 00:00:00
abstract：:In the sea hare, Aplysia californica, consummatory feeding behavior is selectively abolished by bilateral crushes of the cerebral-buccal connectives and recovers by postlesion day 13. Recovered biting responses are initially weak and increase in magnitude gradually with time. The lesions do not affect appetitive feedi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91217-3
更新日期：1992-07-10 00:00:00
abstract：:Cytochrome aa3 (cyt aa3) is the main catalyst of cellular oxygen consumption. The properties of cyt aa3 will define the tissue oxygen requirements and provide an insight into energy supply and demand. Currently dual-wavelength (605-590 or 605-620 nm) reflectance spectrophotometry is used to monitor cyt aa3 redox state...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91236-3
更新日期：1985-12-23 00:00:00
abstract：:Sheep with guide tubes implanted over the brain lateral ventricles, in order to facilitate episodic sampling of cerebrospinal fluid (CSF), were used to determine the effects of increasing cranial blood osmolality or electroconvulsive shock (ECS) on the permeability of the blood-brain barrier (BBB) to zinc. Zinc acetat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90513-b
更新日期：1990-01-15 00:00:00
abstract：:The presence of calretinin and calbindin immunoreactivity is studied in the retina of larval and adult lamprey and their respective distributions are compared. Calretinin distribution is also studied in the retina of transforming stages. Western blot analysis in brain extracts showed a 29-kDa band with both polyclonal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.014
更新日期：2006-01-12 00:00:00
abstract：:The cholecystokinin (CCK) concentration in individual brain stem nuclei of rat was determined using the Palkovits punch method19 and the CCK RIA3, CCK has a unique distribution in the brain stem, unlike other neuropeptides and biogenic amines8,19. In general, the CCK levels in the brain stem are 5-20% of rat cerebral ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90794-6
更新日期：1982-04-22 00:00:00
abstract：:In addition to synaptic remodeling, formation of new neurons is increasingly acknowledged as an important cue for plastic changes in the central nervous system. Whereas all vertebrates retain a moderate neuroproliferative capacity, phylogenetically younger mammals become dramatically impaired in this potential during ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.026
更新日期：2010-05-12 00:00:00
abstract：:Increasing evidences show that hippocampal synaptic plasticity plays a crucial role in the pathogenesis of depression. The objective of this study was to determine whether electroacupuncture (EA) in the Wistar Kyoto (WKY) rat model of depression would exert antidepressant effects and whether this effect would be assoc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.10.033
更新日期：2015-12-10 00:00:00
abstract：:Lesions of the anterior hypothalamus-medial preoptic area (AH-MPOA) impair courtship and copulatory behavior in male Cnemidophorus inornatus, a sexually reproducing species of whiptail lizard, and male-like pseudosexual behaviors in C. uniparens, an all-female species. These results suggest that, since C. inornatus is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90046-9
更新日期：1994-04-18 00:00:00
abstract：:We have examined the effects of isotonic hypovolemia on the expression of the neuronal nitric oxide synthase (nNOS) gene in the paraventricular (PVN) and supraoptic nuclei (SON) of the rat, using in situ hybridization histochemistry with a 35S-labelled oligodeoxynucleotide probe complementary to nNOS mRNA. Intraperito...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01531-x
更新日期：1998-04-20 00:00:00
abstract：:An analysis of cellular kinetics during closure of the cranial neural folds in the C57BL mouse at 8 and 9 days gestations was obtained by means of tritiated thymidine autoradiography. At 8 days the short generation time (7.5 h) and high labeling index (61.4%) are evidence of intensive proliferative activity occurring ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90049-3
更新日期：1981-10-01 00:00:00
abstract：:Fibrates are activators of peroxisome proliferator-activated receptor (PPAR) α. Pretreatment with fibrates has been shown to protect brain against ischemia in mice. We hypothesized that fibrates elevate superoxide dismutase (SOD) levels in the brain microvessels (BMVs). BMVs were isolated from male C57BL/6 and PPARα n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.075
更新日期：2010-11-04 00:00:00
abstract：:Long-term exposure to different antidepressant treatments induces increased motor response to central stimulants, due to a selective supersensitivity of dopamine D2 receptors in the limbic areas. Such an effect is accompanied by down-regulation of dopamine D1 receptor number, and by a decreased response of adenylyl cy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91570-i
更新日期：1993-03-19 00:00:00
abstract：:The principal finding in this study is that the callosal projection to the occipital cortex in rats and mice follows a complex and highly reproducible pattern which has not previously been described in detail. In some regions, the callosal projection is associated with well defined cytoarchitectonic boundaries such as...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91192-6
更新日期：1981-06-15 00:00:00
abstract：:When nomifensine is employed to inhibit neuronal uptake, exposure to dopamine (DA) (0.1-0.3 microM) or apomorphine (0.01-0.1 microM) inhibited, in a concentration-dependent manner, the electrically evoked release of [3H]dopamine from slices of the rabbit caudate nucleus. Apomorphine inhibited transmitter release indep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91605-1
更新日期：1985-06-24 00:00:00
abstract：:To elucidate the intracellular mechanism of the bursting activity which is characteristic of seizure discharge, the behavior of the intracellular cyclic nucleotide and the intracellular calcium during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. Cyclic AMP was increased about 3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90137-3
更新日期：1983-06-20 00:00:00
abstract：:GPR56, a member of the G-protein-coupled receptor family, plays a role in the formation of the frontal and parietal brain lobes and cortical lamination in the embryonic stage. A recent report indicated the existence of GPR56 transcripts in the subventricular zone (SVZ) and hippocampal subgranular zone (SGZ) of the adu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.020
更新日期：2007-12-05 00:00:00
abstract：:In order to improve clinical trial design and translation of normobaric oxygen (NBO) treatment of ischemic stroke, NBO treatment parameters need to be better understood. This study investigated NBO treatment efficacy at two different stroke severities and two NBO treatment durations in rats. For the 60-min middle cere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.030
更新日期：2016-03-15 00:00:00
abstract：:The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90019-8
更新日期：1987-09-01 00:00:00
