Abstract：
:Cytochrome aa3 (cyt aa3) is the main catalyst of cellular oxygen consumption. The properties of cyt aa3 will define the tissue oxygen requirements and provide an insight into energy supply and demand. Currently dual-wavelength (605-590 or 605-620 nm) reflectance spectrophotometry is used to monitor cyt aa3 redox state in vivo. We have experimentally demonstrated that the compensation for blood contamination in the surveyed tissue by these wavelength pairs is less than optimal. An alternative approach, similar to spectrophotometric analysis of multicomponent systems used in vitro, is presented in the triple wavelength equation as follows: delta cyt aa3 = 1.000 (delta A605) - 0.662 (delta A586.1) + 0.316 (delta A580) Based on a series of experiments performed in cuvette in vitro, isolated perfused rat head in situ, and living rat head in vivo, we have demonstrated that the cyt aa3 equation fully compensates for changes in cerebral blood volume and saturation. This non-invasive method of in vivo monitoring of cyt aa3 can provide the means to reliably and accurately determine tissue oxygen delivery under physiological conditions.
journal_name
Brain Resjournal_title
Brain researchauthors
Kariman K,Burkhart DSdoi
10.1016/0006-8993(85)91236-3subject
Has Abstractpub_date
1985-12-23 00:00:00pages
203-13issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(85)91236-3journal_volume
360pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Glycogen synthase kinase (GSK)-3beta and extracellular signal-regulated kinase (ERK) regulate several cellular signaling pathways in common, including embryonic development, cell differentiation and apoptosis. In this study, we investigated whether GSK-3beta inhibition is involved in ERK activation, which affects the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.018
更新日期：2007-12-01 00:00:00
abstract：:The neuronal threshold, which can be determined by the level of depolarization immediately prior to spike generation, is different for responses to conditioned and discriminated stimuli after conditioning. However, it is impossible to determine excitability within a response to stimuli that failed to generate a spike....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02868-8
更新日期：2002-08-09 00:00:00
abstract：:The regional distribution of proline biosynthetic enzymes, ornithine-delta-aminotransferase and delta 1-pyrroline-5-carboxylate reductase, in the rat brain, and basic conditions for proline synthesis from ornithine in rat and chicken brain slices and chicken retinas were investigated. The cerebral regions relating to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91022-5
更新日期：1987-06-16 00:00:00
abstract：:Benzodiazepine binding sites are present on gamma-aminobutyric acid (GABA) receptors in hippocampal neurons. Diazepam is known to potentiate the amplitude and prolong the decay of GABA(A) receptor-mediated inhibitory postsynaptic currents (IPSCs). In this study, benzodiazepine involvement in long-term potentiation (LT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.008
更新日期：2005-11-16 00:00:00
abstract：:Fast axoplasmic transport was examined in experimental nerve ligation and adriamycin-induced neuronal perikaryon lesions. Animals were sacrificed at precisely 3 and 4 h following the injection of [3H]leucine. In single ligated nerves, the 3 and 4 h down-flow rates, which include the time for neuronal processing of lab...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90730-3
更新日期：1979-07-27 00:00:00
abstract：:Certain developmental abnormalities have been associated with environmental exposure to lead and our previous studies have indicated that the endogenous opioid system is disrupted by this metal. In connection with this we report the ontogeny of proenkephalin products in the rat striatum determined by combined HPLC and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90070-7
更新日期：1985-09-01 00:00:00
abstract：:The central myelin sheaths of the recessive autosomal mutant mouse, Shiverer, were investigated by electron microscopy with special reference to the pattern of myelin formation. The results obtained may be summarized as follows: (1) the major dense line of myelin lamellae generally failed to be formed, but the axons w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90269-9
更新日期：1981-08-24 00:00:00
abstract：:The studies were performed on operation material from 17- to 63-year-old patients and on fetuses at 19-23 weeks gestational age. Formaldehyde histofluorescence showed the presence of numerous perivascular adrenergic nerves around pial and intracerebral vessels, the carotid system being better supplied than the vertebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90356-5
更新日期：1976-10-22 00:00:00
abstract：:Female golden-mantled ground squirrels that sustained complete ablation of the suprachiasmatic nucleus (SCNx) were housed pre- and post-operatively at 23 degrees C and then at 6.5 degrees C for 5-7 yr. SCNx and control animals held at the higher temperature manifested circannual rhythms (CARs) in body mass. In contras...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01263-8
更新日期：1998-01-26 00:00:00
abstract：:Mice with reduced expression of the NR1 subunit of the NMDA receptor (NR1 hypomorphic mice) display altered behavioral phenotypes that may relate to behavioral characteristics of schizophrenia. Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical behavioral interactions in tests of socia...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.002
更新日期：2009-04-10 00:00:00
abstract：:Horseradish peroxidase (HRP) in slow-release gel was unilaterally implanted in the transected dorsolateral funiculus (DLF) of either cervical, midthoracic, lumbar or sacral spinal cord levels of adult male rats. Cell mappings were made of all brain areas projecting through the DLF. Following cervical implants, dense l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91139-2
更新日期：1981-11-02 00:00:00
abstract：:Several lines of evidence support a role for nerve growth factor (NGF) in the sympathetic sprouting response that occurs following septal cholinergic denervation of the rat hippocampal formation. The present study was undertaken to compare the distribution of NGF-like immunoreactivity and the topography of sympathetic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01344-h
更新日期：1995-02-20 00:00:00
abstract：:In urethane-anesthetized rats, high frequency stimulation was applied to the medial perforant pathway at various time intervals (50, 100, 200, 350 and 500 ms) following stimulation of the same pathway by a single pulse of equal intensity. Recordings of dentate gyrus granule cell evoked responses were made to investiga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91358-3
更新日期：1988-01-12 00:00:00
abstract：:We examined the contribution of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxalole-4-propionic acid (AMPA)/kainate (KA) receptors to the light-responses of rabbit retinal neurons. In the outer retina, bath application of the AMPA/KA receptor antagonists 6,7-dinitro-quinoxaline-2,3-dione (DNQX) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01448-1
更新日期：1999-06-12 00:00:00
abstract：:A startle-like response can be evoked at low currents by one-pulse electrical stimulation of reticular formation sites from the rostrolateral pons to the caudomedial medulla. To test whether this response is mediated by the same reticular formation neurons as those that mediate the acoustic startle, we delivered a bri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91100-7
更新日期：1993-07-23 00:00:00
abstract：:In the present study, uptake of glutamine by rat cerebellar granule cells, a predominantly glutamatergic nerve cell population, has been investigated. Glutamine is taken up by granule cells via at least three transport systems, A, ASC and L. The L-type low affinity system (K(m) = 2.6 mM) is the major transport system ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00139-x
更新日期：1997-05-16 00:00:00
abstract：:Double impregnation staining of tissue was used to study on thick sections the three-dimensional configuration of the peripheral endoplasmic reticulum in neurosecretory neurons of the supraoptic nucleus in control and water-deprived rats. According to the spatial organization of the endoplasmic reticulum, two types of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90105-7
更新日期：1979-07-13 00:00:00
abstract：:A novel RNA-mediated disease mechanism has emerged from studies on dominantly inherited neurological disorders caused by unstable microsatellite expansions in non-coding regions of the genome. These non-coding tandem repeat expansions trigger the production of unusual RNAs that gain a toxic function, which involves th...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.03.039
更新日期：2014-10-10 00:00:00
abstract：:Glutamate N-methyl-D-aspartate receptors (NMDARs) in the medial prefrontal cortex (mPFC) and hippocampus may play an integral role in complex cognitive and social deficits associated with a number of psychiatric illnesses including autism, mood disorders, and schizophrenia. We used localized infusions of adeno-associa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.037
更新日期：2015-03-10 00:00:00
abstract：:The distribution of retinotectal afferents has been studied by autoradiography in 4 adult cats. The findings suggest that crossed and uncrossed retinal fibers terminate in a striking cluster-and-sheet pattern that varies systematically with respect to the retinotopic map of the colliculus. Following unilateral eye inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90566-1
更新日期：1975-10-10 00:00:00
abstract：:Hemicholinium-3 (HCh-3) is a potent and specific inhibitor of the high-affinity choline transport process (HAChT) localized on cholinergic neurons. In this study, the specific binding of [3H]HCh-3 (120 Ci/mmol) was characterized in crude synaptic membranes prepared from rat brain. The binding of [3H]HCh-3 to forebrain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90451-2
更新日期：1985-12-02 00:00:00
abstract：:Photoreceptor outer segments are continually renewed from base to tip and consequently the membrane at the tip is older than at the base. In parallel with this, there are differences in light responsiveness, and it has been proposed that these may be due to the aforementioned differences in age. We have tested this pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01357-1
更新日期：1997-03-07 00:00:00
abstract：:The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 microM was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [3H]dopamine uptake. Moreover, DDC 1 microM greatly potentiated cell death induced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01457-s
更新日期：1995-03-13 00:00:00
abstract：:Corticotropin-releasing factor (CRF) and dynorphin-related peptides are co-localized within a subset of hypothalamic neurons suggesting the possibility of their co-release. Therefore, studies were performed in conscious unrestrained rats to examine whether dynorphin-related peptides modify the central nervous system (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90713-0
更新日期：1989-05-29 00:00:00
abstract：:The contribution of the activity of afferent fiber filaments to pain and hyperalgesia after administration of a plantar injection of interleukin-1 beta (IL-1 beta) to the hind-paw skin was investigated by recording action potentials of the rat dorsal root in response to mechanical and thermal stimuli. Touch stimuli we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90960-1
更新日期：1994-09-19 00:00:00
abstract：:The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91476-w
更新日期：1990-07-09 00:00:00
abstract：:The vestibular system produces a variety of compensatory responses to accelerations of the head, which include reflex responses recorded from respiratory muscle nerves of the thorax and abdomen. In order to better understand the functional significance of vestibulo-respiratory reflexes, we investigated the extent to w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00674-9
更新日期：1996-10-14 00:00:00
abstract：:alpha-Bungarotoxin (alpha-BuTX) binds in a saturable and practically irreversible fashion to membrane-associated receptors in the ciliary ganglion of the adult chick. The binding of toxin to receptors is competitively inhibited by nicotinic cholinergic ligands, and for these properties the receptors are regarded as ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)91130-7
更新日期：1978-09-15 00:00:00
abstract：:The purpose of this study was to determine the effects of specific proinflammatory cytokines interleukin-6 (Il-6), interleukin-1beta (Il-1beta), interferon-gamma (IFN), and tumor necrosis factor-alpha (TNFalpha), on content and distribution of alpha-synuclein (alpha-synuclein), tau and ubiquitin in human derived cultu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.081
更新日期：2008-06-27 00:00:00
abstract：:The aim of this study was to investigate the degree of functional and anatomical overlap between two major neuronal subpopulations in the rostral ventrolateral medulla: pre-sympathetic (sympathoexcitatory) neurons, and expiratory neurons of the Bötzinger complex. Extracellular recordings were made with dye-filled micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00814-7
更新日期：1995-11-13 00:00:00
