Abstract:
:Ion channels are integral membrane proteins that allow passive diffusion of ions across membranes. In neurons and in other excitable cells, the harmonious coordination between the numerous types of ion channels shape and propagate electrical signals. Increased accumulation of reactive oxidative species (ROS), and subsequent oxidation of proteins, including ion channels, is a hallmark feature of aging and may contribute to cell failure as a result. In this review we discuss the effects of ROS on three major types of ion channels of the central nervous system, namely the potassium (K(+)), calcium (Ca(2+)) and sodium (Na(+)) channels. We examine two general mechanisms through which ROS affect ion channels: via direct oxidation of specific residues and via indirect interference of pathways that regulate the channels. The overall status of the present studies indicates that the interaction of ion channels with ROS is multimodal and pervasive in the central nervous system and likely constitutes a general mechanism of aging susceptibility.
journal_name
Brain Resjournal_title
Brain researchauthors
Patel R,Sesti Fdoi
10.1016/j.brainres.2016.02.046subject
Has Abstractpub_date
2016-05-15 00:00:00pages
174-85eissn
0006-8993issn
1872-6240pii
S0006-8993(16)30105-6journal_volume
1639pub_type
杂志文章,评审相关文献
BRAIN RESEARCH文献大全abstract::Presumptive neurons, immature neurons and degenerating structures were found in the intermediate and deep layers of the superior colliculus of normal cats over the age range 7-45 days postnatal. Electron microscopical analysis revealed these structures to be unexpectedly frequent in the early postnatal period. There w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90013-0
更新日期:1984-05-01 00:00:00
abstract::The distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) was examined in the tooth pulp. In rat and human tooth pulps, PACAP-immunoreactive (IR) nerve fibers were observed around blood vessels and in the subodontoblastic and odontoblastic layers. The predentine and dentine were devoid of such ner...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02876-2
更新日期:2003-08-08 00:00:00
abstract::Quantitative in vitro autoradiography was used to examine [3H]D-Ala2, MePhe4, Gly-015 enkephalin (DAGO) (mu-agonist) and [3H]diprenorphine (general opiate antagonist) binding sites in the hippocampal formation of young (6-8 months) and aged (25-28 months) Long-Evans rats. Age-related changes in these binding sites wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01211-7
更新日期:1996-01-22 00:00:00
abstract::Alcohol-preferring Alko, Alcohol (AA) rats with free access to food and water were taught to voluntarily consume 10% alcohol solution during 20-min sessions. After the drinking session, rats had elevated dopamine release (as reflected by 3-methoxytyramine concentrations) in the nucleus accumbens, olfactory tubercle, a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)81705-2
更新日期:1997-11-07 00:00:00
abstract::The distribution of bFGF in mouse and rat retinas was established using an antibody generated against a rat specific bFGF sequence. The patterns established with this antibody were distinctly different in comparison to the immunostaining patterns using antibodies prepared against similar regions of bovine and human bF...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91236-8
更新日期:1992-07-10 00:00:00
abstract::The addition of L-glutamic acid (Glu) alone, both Glu and glycine (Gly) or Glu/Gly/spermidine (SPD) was effective in potentiating [3H]5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding before equilibrium to an ion channel associated with the N-methyl-D-aspartate (NMDA) receptor complex in b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91029-4
更新日期:1994-02-14 00:00:00
abstract::We report here that following partial spinal transections in adult lampreys, the fibers of the spinal cords can regenerate and restore some intersegmental coordination to the central pattern generator for locomotion, as tested in the isolated cord preparation. However, the regeneration by this test is not successful i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91090-1
更新日期:1989-09-04 00:00:00
abstract::Buffy coat of three members from a family with Alzheimer's disease was inoculated into hamster brains. Eighteen months after the inoculation, all experimental animals were sacrificed for the neuropathological study. Hematoxylin-eosin staining showed no gross vacuolar degeneration, or neuronal loss in the cortex. The s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90949-v
更新日期:1991-06-14 00:00:00
abstract::Ion-selective microelectrode techniques were used to study extracellular K+ changes associated with penicillin-induced epileptogenesis in the CA3 region of hippocampal slices. Recordings were made in slices taken from rats 9-16 days of age, which have a pronounced capacity to undergo prolonged synchronized afterdischa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(86)80203-7
更新日期:1986-12-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by upper and lower motor neuron death with ascending paralysis leading to death. In a transgenic mouse model of ALS (SOD1-G93A) weakness appears at 3 months of age, and because of progressive paralysis leads to death by 5 months. Cyclospo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02012-1
更新日期:2001-03-16 00:00:00
abstract::These experiments used in vivo microdialysis and high-performance liquid chromatography to examine, in rats, norepinephrine (NE) release in the amygdala induced by footshock and systemic administration of drugs affecting the opioid peptidergic system. A microdialysis probe was inserted into a previously implanted guid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00795-1
更新日期:1998-10-19 00:00:00
abstract::Anticipation of an unavoidable painful stimulation, i.e. anticipation stress, induces analgesia. This analgesia may result from activation of the endogenous opioid peptide system as it is blocked by naloxone. The present paper characterizes the anticipation stress further by following the kinetics of the analgesia ris...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91674-0
更新日期:1989-12-04 00:00:00
abstract::In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient temperature of 25°C. The acute hyperthermia following the higher dosages...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.04.039
更新日期:2011-06-29 00:00:00
abstract::Primary cultures of the 21 day foetal rat brain contain a cohort of astroblasts that concertedly acquire glial fibrillary acidic protein (GFAP) filaments between the 16th and 18th hour after plating. This burst of cytoskeletal differentiation is not observed in cultures initiated from the 18 day foetal brain and is no...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90637-7
更新日期:1985-07-22 00:00:00
abstract::The visual properties of cells in the cat ventral lateral geniculate nucleus (LGV) identified antidromically from the pretectum and/or superior colliculus (projection cells) were studied in comparison with those of LGV neurons which could not be activated antidromically (non-projection cells). ON-phasic receptive fiel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90672-4
更新日期:1986-01-15 00:00:00
abstract::Neural plasticity of afferent pain pathways that is induced by prolonged or repeated noxious stimuli may contribute to activate intrinsic inhibitory mechanisms in CNS. In order to clarify the role of the monoaminergic descending inhibitory system in acute nociception and inflammatory pain, we examined if this inhibito...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01086-5
更新日期:1998-12-14 00:00:00
abstract::Somatostatin neuronal perikarya and their processes, presumably dendrites, in the periventricular nucleus of the rat hypothalamus and terminals in the median eminence were observed by electron microscopic immunohistochemistry. Neuronal perikarya and processes contained immunoreactive dense granules (100-120 nm in diam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91153-8
更新日期:1983-01-10 00:00:00
abstract::Analgesia can be elicited following microinjections of morphine, mu-selective agonists and beta-endorphin into the amygdala. These analgesic responses are mediated by opioid synapses in the periaqueductal gray (PAG) since general (naltrexone), mu (beta-funaltrexamine) and delta2 (naltrindole isothiocyanate) opioid ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01115-3
更新日期:1998-01-01 00:00:00
abstract::The effect of anesthesia upon the functional outcome after experimental spinal cord injury (SCI) was studied in 221 rats subjected to graded weight drop contusion in the thoracic cord. Neurologic function was assessed in a blinded fashion for one week after injury using a modification of the method of Tarlov. The post...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91521-h
更新日期:1990-06-25 00:00:00
abstract::Previous data suggest a relationship between the loss of response to levodopa in Parkinson's disease (PD) patients with the co-occurrence of dementia, but the role of alterations in the dopamine system has not been explored. We measured the extent of striatal DA loss and changes in striatal DA D(2) and D(3) receptors ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03396-6
更新日期:2002-11-15 00:00:00
abstract::Hydroxyl free radical production seems to play an important role in the pathogenesis of Parkinson's disease. In the present study, we investigated the dopamine agonists pramipexole and pergolide as well as the nitrone compound S-PBN (N-tert-butyl-alpha-(2-sulfophenyl)nitrone) to reduce hydroxyl radical formation. Micr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02929-2
更新日期:2000-11-17 00:00:00
abstract::The effect of different steady-state cocaine concentration maintenance on the microdialysis extraction fraction of cocaine (in situ recovery; Ed) in the medial prefrontal cortex (mPFC) was examined. Male, adult Sprague-Dawley rats anesthetized with chloral hydrate were used. All rats were randomly divided into three g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00456-z
更新日期:1995-07-24 00:00:00
abstract::Inhibition of nitric oxide (NO) synthesis has been found to produce learning deficits in spatial tasks. Recent studies also suggest a regulatory effect of endogenous NO on hippocampal serotonin (5-HT) release and have shown that NO-synthase (NOS) inhibitors increased extracellular levels of serotonin (5-HT) in the rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03987-2
更新日期:2003-02-14 00:00:00
abstract::A study has been made of the effects of a series of excitatory amino acid receptor antagonists on the field potentials evoked on electrical stimulation of the lateral olfactory tracts of olfactory cortex slices perfused in vitro. The antagonists studied included (+/-)-2-amino-5-phosphonovaleric acid, a potent, specifi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90090-7
更新日期:1982-07-29 00:00:00
abstract::Intradentate administration of colchicine has been reported to affect the cholinergic muscarinic system in the hippocampus, causing a reduction in quinclidinylbenzilate binding sites and an increase in choline acetyltransferase activity. Since the cholinergic muscarinic system is coupled to the formation of inositolph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91419-4
更新日期:1989-01-16 00:00:00
abstract::We previously reported that planarians (Dugesia dorotocephala) that have been exposed to cocaine for 1 h undergo abstinence-induced withdrawal when placed into cocaine-free, but not cocaine-containing, water. We now report that planarians also display dose-related abstinence-induced withdrawal following exposure to th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.103
更新日期:2006-07-12 00:00:00
abstract::Extracellular and intracellular recordings have been made from non-pyramidal neurones in the rat hippocampus in vivo and in vitro. These cells were situated in the stratum pyramidale but were orthodromically activated with a lower threshold than pyramidal neurones in response to stimulation of the Schaffer collateral/...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91235-6
更新日期:1984-02-20 00:00:00
abstract::Alpha-bungarotoxin binding sites in chick retina from 12 days in ovo to hatching, were visualized at the ultrastructural level by use of a 1:1 conjugate of horseradish peroxidase with alpha-bungarotoxin. At all stages binding sites in the inner plexiform layer were localized in synapses, predominantly on or near the p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90774-x
更新日期:1980-11-10 00:00:00
abstract::The localization of the two Ca-activated extralysosomal proteases m-calpain and mu-calpain in the eye of the adult rabbit was examined by immunohistochemistry, using poly- and monoclonal antibodies against the corresponding rabbit antigens. Immunoreactivity against the two forms of calpains was observed in the epithel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90513-m
更新日期:1993-05-21 00:00:00
abstract::L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.08.065
更新日期:2003-12-12 00:00:00