Abstract:
:In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient temperature of 25°C. The acute hyperthermia following the higher dosages was much stronger in males than in females. After the highest dose, body temperature was even raised for several days. This effect was particularly present in males where nocturnal hyperthermia persisted the whole 4-week period of sampling. Despite the differences in the acute hyperthermic response, no significant gender differences were found in 5-HT depletion 4 weeks after MDMA (9 mg/kg) administration. A striking difference was present, however, in the concentration of the 5-HT metabolite 5-HIAA after MDMA administration. In males 5-HIAA levels decreased, whereas in females this metabolite was hardly affected, suggesting a lasting increase in 5-HT turnover in females following drug administration. When genders were matched for their acute physiological hyperthermic response by repeated injection of 9 mg/kg in female rats and 6 mg/kg in male rats, 5-HT depletion was only present in females. In this experiment with matched acute physiological responses 5-HIAA levels also decreased much stronger in males, suggesting an increased 5-HT turnover in females 4 weeks after MDMA administration. In conclusion, although male rats are clearly more susceptible for the acute as well as the lasting hyperthermic effects of MDMA than females, this is not reflected in levels of 5-HT depletion following administration of similar dosages of the drug. This may indicate that, in case of a similar thermogenic response, females have a higher 5-HT neurotoxicity following MDMA than males.
journal_name
Brain Resjournal_title
Brain researchauthors
Wallinga AE,Grahlmann C,Granneman RA,Koolhaas JM,Buwalda Bdoi
10.1016/j.brainres.2011.04.039subject
Has Abstractpub_date
2011-06-29 00:00:00pages
13-20eissn
0006-8993issn
1872-6240pii
S0006-8993(11)00801-8journal_volume
1398pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Increasing adult neurogenesis in the hippocampal formation (HF) has been proposed as a potential foundation for neuronal repair in Alzheimer's disease (AD), but the evidence remains controversial. We used P8 strain of senescence-accelerated mice (SAMP8) as a model of AD to investigate changes in adult neurogenesis. We...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.03.039
更新日期:2011-05-10 00:00:00
abstract::Fos expression in vestibular brainstem and cerebellar regions was evaluated during vestibular adaptation in the Mongolian gerbil. In addition, vestibular adaptation was evaluated in both normal and compensated animals, as vestibular compensation reorganizes the vestibular pathway constraining adaptive processes. Behav...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.05.029
更新日期:2005-07-19 00:00:00
abstract::The dorsolateral quadrant of the lateral septal nucleus receives projections from both the ipsilateral and the contralateral fimbria. In the adult rat the effect of fimbrial lesions on synapse formation has been studied by a quantitative electron microscopic analysis of the various types of synapses present, using ele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90010-4
更新日期:1980-05-05 00:00:00
abstract::Increased alcohol consumption and heightened aggression have been linked to social isolation. Furthermore, animals treated with alcohol following social separation showed higher aggression together with lower serotonin transmission. Although reduced serotonin transmission in the brain may be related to alcohol-induced...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.02.007
更新日期:2017-05-01 00:00:00
abstract::In kittens, but not in adult cats, depriving one eye of pattern vision by suturing the lids shut (monocular deprivation or MD) for one week reduces the proportion of binocular units in the visual cortex. A sensitivity of cortical units in adult cats to MD can be produced by infusing exogenous monoamines into the visua...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90424-3
更新日期:1982-11-04 00:00:00
abstract::Studies were undertaken to characterize the binding of [3H]estradiol ([3H]E2) to blood plasma and to brain cytosols collected from perinatal ferrets of both sexes. A dialysis experiment showed that the binding capacity of plasma for [3H]E2 was low in neonatal ferrets. Saturable, high-affinity binding of [3H]E2 to cyto...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90075-5
更新日期:1983-03-01 00:00:00
abstract::The associative learning functions of the central nervous system of Limax maximus have been established with behavioral experiments on intact animals (Sahley et al., J. comp. Physiol., 144 (1981) 1) and physiological experiments on the isolated CNS (Culligan and Gelperin, Brain Research, 266 (1983) 319). We now report...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90323-8
更新日期:1984-06-25 00:00:00
abstract::Mitochondria critically regulate cytoplasmic Ca(2+) concentration ([Ca(2+)]c), but the effects of sensory neuron injury have not been examined. Using FCCP (1µM) to eliminate mitochondrial Ca(2+) uptake combined with oligomycin (10µM) to prevent ATP depletion, we first identified features of depolarization-induced neur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.040
更新日期:2014-11-17 00:00:00
abstract::Three weeks of hypoxic exposure results in a spectrum of systemic physiological and local brain tissue adaptations. Cytochrome oxidase histochemistry was used as an indicator of changes in energy demand in response to hypoxia. We found overall cytochrome oxidase activity decreased in hypoxic adapted rats as compared t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01495-0
更新日期:1996-05-13 00:00:00
abstract::Perceptual performance in persons with hearing loss, especially those using devices to restore hearing, is not fully predicted by traditional audiometric measurements designed to evaluate the status of peripheral function. The integrity of auditory brainstem synapses may vary with different forms of hearing loss, and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.012
更新日期:2015-04-24 00:00:00
abstract::Experiments were conducted to examine sex differences in striatal dopamine function using in vivo microdialysis in freely moving rats. We report here a sex difference in basal extracellular striatal dopamine determined by quantitative microdialysis (the no net flux method) when castrated and ovariectomized rats were c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91225-h
更新日期:1993-04-30 00:00:00
abstract::An extensive exploration of the discriminating properties of olfactory receptors cells has been conducted in our laboratory through the statistical processing of single cell responses recorded in the frog's olfactory epithelium. Similarities between odorant stimulating properties could be demonstrated by comparing the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90764-9
更新日期:1984-02-06 00:00:00
abstract::The potential shifts (delta Vo) associated with spreading depression (SD) were analysed with the help of multiple extracellular recording and ion-selective microelectrodes in the CA1 region of the dorsal hippocampus of anesthetized rats. Recurrent waves of SD were induced by perfusing high K+ solution through microdia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91412-l
更新日期:1993-05-07 00:00:00
abstract::The morphology, dendritic stratification and laminal position of the soma of retinal ganglion cells were analyzed in Golgi preparations and in other rabbit retinas containing cells backfilled from the superior colliculus. Only one type, among 40 Golgi-impregnated types identified, always had its cell body displaced to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91838-8
更新日期:1990-12-03 00:00:00
abstract::Neuronal activity in the nucleus parabrachialis medialis (NPBM) was examined in unanesthetized, unrestrained cats during each sleep-waking state. Discharge related to the cardiac cycle was assessed by calculating cross-correlation functions between neuronal and cardiac events (using the peak of the EKG 'R' wave as a r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90696-4
更新日期:1980-10-20 00:00:00
abstract::In auditory speech processing, phonological stress functions as an attention holding cue, which facilitates detection of mispronunciations and phonetic deviants in strong syllables as compared to weak ones. Whereas silent reading involves activation of phonological information including word stress, it is not clear wh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.01.003
更新日期:2016-04-01 00:00:00
abstract::Electrophysiological characteristics were described for neurons of the parabrachial nucleus (PBN) which receive baroreceptive and somatosensory inputs in the rat. Following focal electrical stimulation in the ipsilateral caudal nucleus of the tractus solitarii (NTS), the firing rates of these neurons were increased in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91704-5
更新日期:1991-12-06 00:00:00
abstract::Maternal care is crucial for offspring development and licking/grooming patterns can be induced by sensorial, neuroendocrine, and metabolic variations in the CNS. Important brain functions, such as learning and memory, can be influenced by oxidative stress, which can also modulate pathophysiological processes (e.g., d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.11.010
更新日期:2017-01-15 00:00:00
abstract::In urethane-anesthetized rats, high frequency stimulation was applied to the medial perforant pathway at various time intervals (50, 100, 200, 350 and 500 ms) following stimulation of the same pathway by a single pulse of equal intensity. Recordings of dentate gyrus granule cell evoked responses were made to investiga...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91358-3
更新日期:1988-01-12 00:00:00
abstract::Brain protein kinase B (Akt) and glycogen synthase kinase-3 (GSK-3) activities are adaptable to changes of peripheral blood glucose level in vivo. GSK-3 phosphorylates microtube-associated protein tau at multiple sites, which can be antagonized by protein phosphatase-2A (PP-2A). The imbalance among these enzymes might...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.01.084
更新日期:2011-04-06 00:00:00
abstract::The understanding of sentences involves not only the retrieval of the meaning of single words, but the identification of the relation between a verb and its arguments. The way the brain manages to process word meaning and syntactic relations during language comprehension on-line still is a matter of debate. Here we re...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2006.08.038
更新日期:2007-05-18 00:00:00
abstract::Emotional events are preferentially retained in episodic memory. This effect is commonly attributed to enhanced consolidation and has been linked specifically to rapid eye movement (REM) sleep physiology. While several studies have demonstrated an enhancing effect of REM sleep on emotional item memory, it has not been...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.06.020
更新日期:2018-11-01 00:00:00
abstract::We have shown that, when an amyloid-beta peptide (Abeta) overproducing transgenic mouse model (PSAPP) of Alzheimer's disease (AD) is treated with a depleting antibody against CD40L, it causes marked attenuation of Abeta pathology associated with decreased amyloidogenic processing of amyloid precursor protein (APP) and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.004
更新日期:2004-07-23 00:00:00
abstract::Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.01.050
更新日期:2004-04-09 00:00:00
abstract::The second of two targets (T2) presented in a rapid visual stream is often missed when presented shortly after the first (T1). This phenomenon has been referred to as the attentional blink. Here we show that the presentation of a synchronous sound enables T2 to escape the attentional blink, to the extent that performa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.070
更新日期:2008-11-25 00:00:00
abstract::Ca2+-permeable AMPA receptors (AMPAR) which crucially modify maturational programs of the developing brain are involved in seizure-induced glutamate excitotoxicity and apoptosis. Regulatory effects on AMPAR subunit composition and RNA-editing in the developing brain and their significance as therapeutic targets are no...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146760
更新日期:2020-05-15 00:00:00
abstract::Electrical stimulation of the subfornical organ (SFO) in urethane anesthetized male Sprague-Dawley rats was associated with intensity and frequency dependent increases in arterial blood pressure. Stimulation in the hypothalamic paraventricular nucleus (PVN) also evoked increases in arterial blood pressure. Electrolyti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90443-8
更新日期:1984-07-09 00:00:00
abstract::The effect of arginine vasopressin (AVP) on protein phosphorylation in rat hippocampal synaptic plasma membranes (SPM) was examined. With a crude SPM preparation, AVP (10(-8)-10(-5) M) stimulated phosphorylation of a number of proteins which included a brain-specific protein of 48 kDa called B50 or protein F1, which i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91231-x
更新日期:1986-10-01 00:00:00
abstract::We have developed a computer-assisted method for analyzing the 2-deoxyglucose (2-DG) autoradiograms of mice olfactory bulbs. The purpose of the study was to numerize the maps of glomerular activation in order to achieve a statistical comparison of the glomerular patterns evoked by different stimuli. The spatial distri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90173-9
更新日期:1987-08-04 00:00:00
abstract::Our recent study has shown that many afferent fibers in the ventral root are third branches of dorsal root ganglion cells in addition to their processes in the peripheral nerve and the dorsal root. From results of this study, we hypothesized that most of the afferent fibers in the normal ventral root are extra process...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91030-5
更新日期:1989-10-30 00:00:00