Abstract：
:We previously reported that planarians (Dugesia dorotocephala) that have been exposed to cocaine for 1 h undergo abstinence-induced withdrawal when placed into cocaine-free, but not cocaine-containing, water. We now report that planarians also display dose-related abstinence-induced withdrawal following exposure to the synthetic cannabinoid agonist WIN 55212-2, but not its inactive enantiomer (WIN 55212-3). The withdrawal from WIN 55212-2 was manifested as a significant (P < 0.05) decrease in the rate of planarian spontaneous locomotor activity over a 5-min observation period, using a recently designed metric (pLMV). We also report that withdrawal from cocaine (80 microM) or WIN 55212-2 (10 microM) was attenuated by the selective inhibitor of nitric oxide synthesis L-NAME (L-nitro-arginine methyl ester), which had no effect of its own on pLMV. These results suggest a common NO-dependent pathway of withdrawal from cocaine and WIN 55212-2 in Planaria.
journal_name
Brain Resjournal_title
Brain researchauthors
Rawls SM,Rodriguez T,Baron DA,Raffa RBdoi
10.1016/j.brainres.2006.04.103subject
Has Abstractpub_date
2006-07-12 00:00:00pages
82-7issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)01305-9journal_volume
1099pub_type
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