Abstract:
:Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease (PD) model, but the underlying mechanism of this action was not extensively elucidated. To address this question, we established 6-hydroxydopamine (6-OHDA) induced human dopaminergic cell line SH-SY5Y as PD cell model and testified the neuroprotection of IP6. Through hoechst nuclear stain method and flow cytometric analysis, apoptosis induced by 6-OHDA was blocked by IP6 pretreatment. Significant protection against reactive oxygen species (ROS) and lipid peroxidation product malondialdehyde (MDA) was observed in 6-OHDA induced cells pretreated with IP6. To further investigate the mechanism of anti-apoptotic effect of IP6, expression of mediators in mitochondrion dependent apoptotic pathway was detected. Results indicated that loss of mitochondrial membrane potential, cytochrome c releasing, upregulation of Bcl-2-associated X protein (Bax), downregulation of B-cell CLL/lymphoma 2 (Bcl-2) and caspases activation were reversed by IP6. In addition, using flow cytometric method and western blot approach, our data showed that IP6 attenuated the rise of calcium and α-synuclein aggregation in cytosol. Collectively, IP6 exerted its neuroprotection on dopaminergic cells in PD cell model and the mechanism may be associated with changes of mitochondrion mediated apoptotic pathway and α-synuclein aggregation.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhang Z,Hou L,Li X,Ju C,Zhang J,Li X,Wang X,Liu C,Lv Y,Wang Ydoi
10.1016/j.brainres.2015.12.035subject
Has Abstractpub_date
2016-02-15 00:00:00pages
87-95eissn
0006-8993issn
1872-6240pii
S0006-8993(15)00974-9journal_volume
1633pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Reactive oxygen species (ROS) are supposed to be involved in neurodegenerative processes like Parkinson's or Alzheimer's disease. Beside this there are an increasing number of studies indicating an involvement of ROS in traumatic brain injury. We therefore studied the potential role of astrocytes against neurotoxic ef...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01029-3
更新日期:1996-12-16 00:00:00
abstract::Insulin and the insulin-like growth factors (IGFs) may directly affect the growth, development, and maintenance of the vertebrate nervous system. Previous in vitro studies have focused on embryonic nervous tissue. In this study the effects of insulin, IGF-I, IGF-II and nerve growth factor (NGF) on regeneration and neu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91496-f
更新日期:1993-04-02 00:00:00
abstract::Adult Sprague-Dawley rats were exposed to a single session of 100 inescapable tail shocks (IS). Bromodeoxyuridine (BrdU) was administered 1 h, 2 days or 7 days later and hippocampal cell proliferation (CP) was assessed after a 2-h survival period. Measures of plasma corticosterone (CORT) levels were also obtained. Des...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.081
更新日期:2007-01-26 00:00:00
abstract::The effects of glucose injection into the hepatic portal vein on neural activity of the lateral hypothalamic area (LHA) were studied in rats. A majority of identified glucose-sensitive neurons in the LHA were inhibited by portal injection of glucose. This was found to be mediated through the alpha-noradrenergic pathwa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91332-x
更新日期:1983-04-11 00:00:00
abstract::A novel gold phosphate complex called Black-Gold II with improved myelin staining properties has been developed. It differs from its predecessor, Black-Gold, in that it is highly water soluble at room temperature. This unique physical property confers a number of advantages for the high resolution staining of myelinat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.06.129
更新日期:2008-09-10 00:00:00
abstract::The technique of intracranial microdialysis was used to investigate the effects of aging on the striatal dopaminergic system of the anesthetized Fischer 344 rat. Microdialysis probes were implanted into the striatum of young (2-8 months) and aged (24-28 months) urethane anesthetized rats. Striatal dialysate levels wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01095-6
更新日期:1999-01-16 00:00:00
abstract::Mouse brain was found by immunoblot analysis to have a protein of Mr 23,000 (P23k) that was clearly different from recoverin and was labeled with an antiserum raised against the NH2-terminus of recoverin. P23k could not be detected by an antiserum raised against the COOH-terminus of recoverin. Blots with 45Ca demonstr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90676-z
更新日期:1992-02-07 00:00:00
abstract::Bromodeoxyuridine (BrUdR) injected into Xenopus embryos at stages before, during or after the last period of DNA synthesis in Mauthner's neurons had no serious effect on differentiation of Mauthner's neurons. However, the BrUdR caused widespread cell degeneration in the central nervous system. The action of BrUdR on r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90819-3
更新日期:1978-07-21 00:00:00
abstract::In intracellular recordings from the CA1 region of the hippocampal slice preparation, an infrequent cell type different from the predominant pyramidal cell has been characterized. The cells have very brief spikes, hyperpolarizing after-potentials, and tend to fire at a high spontaneous rate; unitary synaptic potential...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90991-5
更新日期:1978-11-17 00:00:00
abstract::The neurite promoting factors in the astroglial conditioned medium (As-CM) were characterized by using primary cultures of embryonic rat neocortical neurons. The factors in the As-CM bind to lectins such as wheat germ agglutinin (WGA), suggesting that they contain sugar moieties. When the WGA-bound fractions were appl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91059-p
更新日期:1990-09-10 00:00:00
abstract::The succinic semialdehyde dehydrogenase (SSADH) null mouse (SSADH(-/-)) represents a viable animal model for human SSADH deficiency and is characterized by markedly elevated levels of both gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acid (GABA) in brain, blood, and urine. In physiological concentrations, GH...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.02.131
更新日期:2006-05-23 00:00:00
abstract::High affinity D-[3H]aspartate uptake and amino acid concentrations were examined in synaptosome-enriched preparations of microdissected rat ventral tegmental area 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90140-4
更新日期:1985-04-29 00:00:00
abstract::Angiotensin converting enzyme (ACE) is Zn2+ metallopeptidase which plays an important role in blood pressure homeostasis in mammals and other vertebrates. Homologues of ACE involved in the biosynthesis of mammalian peptide hormones have also been identified in the insects, Musca domestica, Drosophila melanogaster and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01398-x
更新日期:1998-03-02 00:00:00
abstract::Visual spatial orienting of attention towards exogenous cues has been one of the attentional functions considered to be spared in ADHD. Here we present a design in which 60 (30 ADHD) children, age: 10.9±1.4, were asked to covertly orient their attention to one or two (out of four) cued locations, and search for a targ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.11.036
更新日期:2013-02-01 00:00:00
abstract::Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer׳s and Parkinson׳s ...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2016.02.049
更新日期:2016-10-15 00:00:00
abstract::Binding sites for iodinated endothelin (ET)-2, ET-3 and vasoactive intestinal contractor (VIC) were visualised in the adult rat brain using quantitative autoradiography and have a similar anatomical distribution to that of ET-1 and sarafotoxin S6b. Highest densities of binding sites for all 5 labelled peptides were pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90201-6
更新日期:1991-07-19 00:00:00
abstract::Sleep-suppressive activity of prostaglandin synthesis inhibitors, diclofenac sodium (DF) and indomethacin (IM), was examined in unrestrained male rats. An intraperitoneal injection of 5 mg/kg IM, or an oral administration of 5 mg/kg DF and 10 mg/kg IM at an early phase of the light period transiently decreased slow wa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90173-4
更新日期:1988-06-21 00:00:00
abstract::The central nervous system of the snail Helisoma duryi contains porcine insulin-immunoreactive cells. Most of these cells are known as neurosecretory mediodorsal cells (MDC), and are involved in regulation of growth. There are about 25-40 large and small MDC in each cerebral ganglion near the commissure. Besides the M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90933-z
更新日期:1992-05-15 00:00:00
abstract::The present study investigated differences between vestibulo-somatic and vestibulo-sympathetic reflexes, along with differences between somatic and autonomic spino-bulbo-spinal (SBS) reflexes in chloralose-urethane anesthetized cats. Electrical stimulation was applied to the vestibular nerve (V) for a duration of 0.3 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90221-5
更新日期:1985-05-20 00:00:00
abstract::Retrograde axonal transport method of the fluorescent tracer FluoroGold (FG) was combined with immunocytochemistry to investigate the occurrence of nitric oxide synthase (NOS), somatostatin (SOM), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in both intrinsic and cortically projecting neurons of the ra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02408-8
更新日期:2001-06-29 00:00:00
abstract::In the present study, we used an immunocytochemical technique at the electron microscopic level to determine if there are changes in the glutamate and GABA neurotransmitter content of the hippocampus of genetic absence epilepsy rats from Strasbourg (GAERS). We also investigated if there was mossy fiber reorganization....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03349-3
更新日期:2003-10-24 00:00:00
abstract::Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward currents with a decrease in membrane conductance at a holding potential...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91232-7
更新日期:1994-02-21 00:00:00
abstract::A study was made of the effects of electrochemically stimulating (ECS) and destroying the midbrain dorsal and median raphe nuclei on the estrogen-progesterone- (EP) induced surge of pituitary LH release in ovariectomized rats. ECS and lesions were produced simultaneously with anodal direct current through a chronicall...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90006-8
更新日期:1981-08-03 00:00:00
abstract::Sodium and potassium currents in the node of Ranvier decrease exponentially with time during long lasting voltage clamp experiments. This decline is strongly dependent on temperature (Q10 approximately 3). Thiamine and, particularly, its diand triphosphoric acid esters are shown to prevent this exponential decline of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90720-9
更新日期:1975-05-23 00:00:00
abstract::The cellular and subcellular localization of aspartate in the guinea pig inner ear was studied by means of quantitative postembedding cytochemistry. High levels of aspartate immunoreactivity were found in neuronal compartments, including all types of hair cells, and afferent and efferent nerve fibers. In addition, sub...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01001-3
更新日期:1996-12-02 00:00:00
abstract::The purpose of the present study was to examine the role of substrate availability in the regulation of the release and synthesis of serotonin by brain slices. Electrical field depolarization of the brain slices stimulated the synthesis and release of serotonin in the absence of changes in intracellular tryptophan con...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90580-8
更新日期:1979-08-31 00:00:00
abstract::The actions of pentobarbital (PB) and diphenylhydantoin (DPH) have been studied on neurons of dorsal root ganglia from adult rats. At anesthetic level (i.e. 1--2 x 10(-4) M), PB greatly enhanced neuronal responses to gamma-aminobutyric acid (GABA); at 10(-3) M PB caused a small depolarization and profoundly attenuated...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90370-x
更新日期:1981-03-02 00:00:00
abstract::The aim of this study is to verify whether anatomical changes occur in the brains of chess players. Besides, it is a potential attempt to evaluate diffusion properties along the tracts due to the diverse situations at anatomical level in different locations; moreover, conventional voxel-based analysis (VBA) has alread...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.07.003
更新日期:2018-12-01 00:00:00
abstract::The influence of the cortico-geniculate pathway on identified X and Y lateral geniculate cells was studied by reversibly cooling visual cortical areas 17 and 18. The majority (86.5%) of cells changed their response to visual stimulation when cortex was inactivated, and both X- and Y-cells were modulated by the cortica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90568-0
更新日期:1981-03-16 00:00:00
abstract::The mouse auditory neurons, hair cells and their supporting cells in the cochlea are considered to be generated mainly in the embryonic days and to be sustained throughout the whole life. In the present study, however, we observed that auditory ganglion cells in the spiral ganglia undergo apoptosis and mitosis in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02300-9
更新日期:2001-05-18 00:00:00