Abstract：
:In the present study, the effects of bilateral injections of N-methyl-d-aspartate (NMDA) receptor agonist and/or antagonist into the central amygdala (CeA) on the acquisition and expression of morphine-induced conditioned place preference (CPP) were investigated in male Wistar rats. Animals that received 3 daily subcutaneous (s.c.) injections of morphine (1-9 mg/kg) or saline (1.0 ml/kg) indicated a significant preference for compartment paired with morphine in a dose dependent manner. Intra-CeA administration of the NMDA (0.01, 0.1 or 1 microg/rat) with an ineffective dose of morphine (1 mg/kg, s.c.) elicited a significant CPP. Administration of the non-competitive NMDA receptor antagonist, MK-801 (0.1, 0.3 or 0.5 microg/rat), into the central amygdala dose-dependently inhibited the morphine (6 mg/kg, s.c.)-induced place preference. Furthermore, intra-CeA administration of MK-801 (0.25, 0.5 or 1 microg/rat) reduced the response induced by NMDA (1 microg/rat, intra-CeA) plus morphine (1 mg/kg, s.c.). Neither NMDA nor MK-801 alone produce a significant place preference or place aversion. Moreover, intra-CeA injection of NMDA but not MK-801 before testing significantly increased the expression of morphine (6 mg/kg, s.c.)-induced place preference. NMDA or MK-801 injections into the CeA had no effects on locomotor activity on the testing sessions. These results suggest that the NMDA receptor mechanisms in the central amygdala may be involved in the acquisition and expression of morphine-induced place preference.
journal_name
Brain Resjournal_title
Brain researchauthors
Rezayof A,Golhasani-Keshtan F,Haeri-Rohani A,Zarrindast MRdoi
10.1016/j.brainres.2006.11.049subject
Has Abstractpub_date
2007-02-16 00:00:00pages
34-41issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)03421-4journal_volume
1133pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Epidemiological studies indicate that women have a higher risk of Alzheimer's disease (AD) even after adjustment for age. Though transgenic mouse models of AD develop AD-related amyloid beta (Abeta) and/or tau pathology, gender differences have not been well documented in these models. In this study, we found that fem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.079
更新日期：2008-06-24 00:00:00
abstract：:Alpha-bungarotoxin binding sites in chick retina from 12 days in ovo to hatching, were visualized at the ultrastructural level by use of a 1:1 conjugate of horseradish peroxidase with alpha-bungarotoxin. At all stages binding sites in the inner plexiform layer were localized in synapses, predominantly on or near the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90774-x
更新日期：1980-11-10 00:00:00
abstract：:Previous research has shown that injection of morphine into the ventral tegmental area (VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal behavior in parturient rats. Placentophagia -- ingestion of placen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.015
更新日期：2009-03-19 00:00:00
abstract：:Striatal glial cell line-derived neurotrophic factor (GDNF) mRNA levels in both young (2-month old) and old (11-month old) C57BL/6J mice were quantified at 3, 7 and 21 days following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. MPTP did not alter the expression of GDNF mRNA in these animals. Immunore...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01254-8
更新日期：1999-05-01 00:00:00
abstract：:Bilateral microinjections of the neuroleptic, cis-flupenthixol, were made into 56 forebrain targets distributed across various dopamine (DA) terminal fields in the forebrain. Drug effects on medial forebrain bundle (MFB) stimulation-produced reward were assessed with a rate-frequency procedure implemented in a runway ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91400-5
更新日期：1989-01-16 00:00:00
abstract：:An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by a 6-day withdrawal. Perfusi...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-08-12 00:00:00
abstract：:Abeta amyloidosis and tauopathy are characteristic changes in the brain of Alzheimer's disease. Although much evidence suggests that Abeta deposit is a critical initiation factor, the pathological pathway between Abeta amyloidosis and tau accumulation remains unclear. Tau accumulation was examined in the doubly transg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.134
更新日期：2006-06-13 00:00:00
abstract：:Bilateral quisqualic acid-induced lesions of the nucleus basalis magnocellularis (nbm) in rats disrupted the expression of latent inhibition, a phenomenon thought to be dependent upon selective attention processes. Since grafts of adrenal chromaffin cells to the cerebral cortex of nbm-lesioned rats have been shown to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01364-n
更新日期：1995-02-13 00:00:00
abstract：:Prolidase deficiency is characterized by chronic ulcerative dermatitis, mental retardation, and frequent infections. In the present study we examined the characteristics of rat brain prolidase isoenzymes. Prolidase isoenzymes (PD I and PD II) were isolated from the rat brain using DEAE cellulose column chromatography....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.081
更新日期：2009-12-15 00:00:00
abstract：:Respiratory neurons were recorded with microelectrodes in the medullary dorsal respiratory group of pentobarbital-anesthetized cats. The animals were ventilated with a phrenic-driven servorespirator that allowed manipulation of phasic volume feedback. By increasing or decreasing the gain of the servorespirator, graded...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90924-5
更新日期：1980-11-03 00:00:00
abstract：:The present study examined the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on the 5-HT1B and 5-HT1D autoreceptors controlling 5-HT efflux in slices of rat ventrolateral geniculate nucleus. Electrically stimulated 5-HT efflux (10 pulses, 200 Hz, 0.1 ms, 10 mA) was measured using fast cyclic voltammetry. Peak ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00289-8
更新日期：1997-06-20 00:00:00
abstract：:Prostaglandins are now thought to play an important role in nociceptive information transmission in the spinal cord. Prostaglandins are known to be produced by cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid. Two forms of COX have been identified: COX-1, which is constitutively expressed in mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00817-7
更新日期：1996-11-11 00:00:00
abstract：:Using psychophysical techniques, the ability of human subjects to discriminate the velocity of brush movement across the glabrous skin of the hand was determined. The same stimulus was then used in a series of neurophysiological experiments designed to determine the ability of neurons in the primary somatosensory cort...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90746-5
更新日期：1980-10-06 00:00:00
abstract：:Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02400-8
更新日期：2000-07-07 00:00:00
abstract：:Locations of cells responsive to microiontophoretically applied angiotensin II (AII) were compared to distributions of AII receptor binding sites identified by autoradiography in the lumbar enlargement region of the rat spinal cord. Angiotensin II receptor binding sites were densely concentrated in the superficial lay...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91398-4
更新日期：1988-02-16 00:00:00
abstract：:The current study investigated the time course of the implicit processing of erotic stimuli using event-related potentials (ERPs). ERPs elicited by erotic pictures were compared with those by three other types of pictures: non-erotic positive, negative, and neutral pictures. We observed that erotic pictures evoked enh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.019
更新日期：2012-12-13 00:00:00
abstract：:Oligodendrocyte precursor cells (OPCs) react rapidly to brain and spinal cord injuries. This reaction is characterized by the retraction of cell processes, cell body swelling and increased expression of the NG2 chondroitin sulfate proteoglycan. Reactive OPCs rapidly divide and accumulate surrounding the injury site wh...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.07.026
更新日期：2016-05-01 00:00:00
abstract：:The effects of substantia nigra (SN) stimulation on the activity of the nucleus ventralis lateralis of the thalamus (VL) have been studied. The VL cells were identified as relay or non-relay cells among the cerebellothalamocortical pathway on the basis of orthodromical activation from the cerebellum and antidromical a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90793-x
更新日期：1978-04-21 00:00:00
abstract：:We investigated the effect of high dose tetrodotoxin (TTX) on microdialysis measurements of extracellular striatal glutamate and dopamine in normal female rats. Both halothane-anesthetized rats with acutely implanted microdialysis probes and awake rats with microdialysis probes implanted for 24 h were tested. Glutamat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00258-8
更新日期：1997-06-13 00:00:00
abstract：:Na-independent [3H]glutamate binding to rat hippocampal membranes increases progressively as a function of age. The increased binding represents an increased number of binding sites without changes in their apparent affinity for glutamate. However, [3H]glutamate binding, measured with a saturating concentration of cal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90823-4
更新日期：1981-10-26 00:00:00
abstract：:Dipiperidinoethane (DPE) administration produces seizures and CNS lesions. Here we elucidate the cholinergic origin of DPE toxicity. DPE is both an acetylcholinesterase (AChE) inhibitor and a muscarinic antagonist. This dual action negates most of the toxic effects of the compound in vivo. The neurotoxicity is believe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90728-0
更新日期：1985-04-01 00:00:00
abstract：:The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Intrastriatal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90026-1
更新日期：1988-06-14 00:00:00
abstract：:The purpose of this review is to provide strategies and their rationale which can facilitate scientifically productive investigations into genetic, neuronal, brain functional and clinical aspects of bipolar disorder. The presentation addresses both factors that have impeded and those that have facilitated landmark adv...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2008.05.084
更新日期：2008-10-15 00:00:00
abstract：:Onset of hearing in the ferret was judged by simple behavioral, physiological and anatomical indices. The ear canals do not open until the end of the first postnatal month. This coincides with the appearance of a startle response to loud hand claps and the recording of acoustically activated neurons in the midbrain. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90698-9
更新日期：1982-12-16 00:00:00
abstract：:Bradykinin is known to rapidly elevate intracellular calcium leading to secretion of neurotransmitters and short term activation of tyrosine hydroxylase (TH). In this study we examined the effect of bradykinin on mRNA levels of two catecholamine biosynthetic enzymes. Treatment of PC12 cells with 1 microM bradykinin fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91477-a
更新日期：1993-04-16 00:00:00
abstract：:Significant insights into the dynamics of neuronal populations have been gained in the olfactory system where rich spatio-temporal dynamics is observed during, and following, exposure to odours. It is now widely accepted that odour identity is represented in terms of stimulus-specific rate patterning observed in the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.032
更新日期：2012-01-24 00:00:00
abstract：:The visual properties of cells in the cat ventral lateral geniculate nucleus (LGV) identified antidromically from the pretectum and/or superior colliculus (projection cells) were studied in comparison with those of LGV neurons which could not be activated antidromically (non-projection cells). ON-phasic receptive fiel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90672-4
更新日期：1986-01-15 00:00:00
abstract：OBJECTIVE:Previously, we found that the inhaled anesthetic isoflurane up-regulated the transcriptional factor hypoxia inducible factor (HIF)-1α protein levels during induction of neurodegeneration in the brain of neonatal rats. Here, we investigated the role of HIF-1α and the underlying signaling pathway in the neurode...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.014
更新日期：2016-12-15 00:00:00
abstract：:The syndrome of benign familial neonatal convulsions (BFNC) is characterized by seizures starting within the first days of life and disappearing within weeks to months. BFNC is caused by loss-of-function mutations in the potassium channels KCNQ2 and KCNQ3 which can well explain the resulting neuronal hyperexcitability...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.023
更新日期：2006-03-10 00:00:00
abstract：:Experiments were performed in the male Wistar rat to investigate the projections from cardiovascular responsive sites in the ventrolateral medulla (VLM) to the subfornical organ (SFO). Unilateral iontophoretic injections of Phaseolus vulgaris leucoagglutinin (PHA-L) were made into either caudal VLM (CVLM) sites at whi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.12.029
更新日期：2004-04-02 00:00:00
