Abstract：
:An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by a 6-day withdrawal. Perfusion of 0.1 mM (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid through a microdialysis probe placed in the striatum enhanced the extracellular dopamine level, and induced stereotyped behavior in MAP-sensitized rats. The enhancement of dopamine release and the stereotyped behavior were attenuated by co-perfusion of 0.4 mM RS-alpha-methyl-4-carboxyphenyl-glycine, a mGluR antagonist. The present results suggest that mGluRs may be involved in the expression of MAP-induced sensitization.
journal_name
Brain Resjournal_title
Brain researchauthors
Arai I,Shimazoe T,Shibata S,Inoue H,Yoshimatsu A,Watanabe Ssubject
Has Abstractpub_date
1996-08-12 00:00:00pages
277-80issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00581-1journal_volume
729pub_type
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