Abstract：
:Senescent (26-28 months) Fischer 344 rats were shown to have a lower density of D2 sites (-36%) without any change in affinity in membranes prepared from homogenized caudate-putamen (CPU), as compared to young adult (5-6 months) rats. In additional rats prepared for quantitative autoradiography of [3H]spiroperidol binding, the loss was shown to be specific for and quite extensive (50-60%) in the lateral to ventrolateral region of the CPU. The region of the CPU that shows the major age-related loss of D2 sites is critically involved in sensorimotor functions; therefore this regional loss of D2 sites may contribute importantly to the sensorimotor deficits in aged rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Joyce JN,Loeschen SK,Sapp DW,Marshall JFdoi
10.1016/0006-8993(86)90298-2subject
Has Abstractpub_date
1986-07-16 00:00:00pages
158-63issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)90298-2journal_volume
378pub_type
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