Abstract：
:Oral ENA713 (0.5, 1.5 and 4.5 mg/kg), an acetylcholinesterase inhibitor (AChEI), dose-dependently enhanced extracellular acetylcholine concentrations in the hippocampus of freely moving rats. This effect was paralleled by changes in both noradrenergic and dopaminergic transmission. In particular, ENA713 significantly decreased noradrenaline concentrations, whereas it significantly increased homovanillic acid levels, without affecting dopamine concentrations. Neither serotonin nor gamma-aminobutyric acid levels were modified by ENA713. These findings extend the neurochemical profile of ENA713 and suggest that it could be useful for the treatment of Alzheimer-type dementia which is associated with multiple neurotransmitter abnormalities in the brain.
journal_name
Brain Resjournal_title
Brain researchauthors
Trabace L,Coluccia A,Gaetani S,Tattoli M,Cagiano R,Pietra C,Kendrick KM,Cuomo Vdoi
10.1016/s0006-8993(00)02266-6subject
Has Abstractpub_date
2000-05-26 00:00:00pages
268-71issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02266-6journal_volume
865pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Male rats were treated with barbital in their drinking fluid for about 40 weeks (daily dose 200 mg/kg). The treatment was stopped on day 0 and the number of muscarinic binding sites was measured in 3 brain parts (striatum; cortex and hippocampus; medulla oblongata and midbrain) during the abstinence with labeled quinu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90146-9
更新日期：1982-08-19 00:00:00
abstract：:Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00072-9
更新日期：1998-04-20 00:00:00
abstract：:Experiments were done in cats to identify neurons in the paramedian reticular nucleus (PRN) sending collateral axons to the region of the intermediolateral nucleus (IML) at different levels of the thoracic cord by using lectin-conjugated horseradish peroxidase (HRP) and double-labeling fluorochrome histochemistry to r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90377-5
更新日期：1987-04-07 00:00:00
abstract：:We assessed the application of a replication deficient recombinant adenovirus vector as a retrograde tracer in neural pathway studies. The adenovirus vector, Ad. RSV betagal, containing the intracellular marker gene, beta-galactosidase, was injected directly into the laterodorsal striatum of rats. The retrograde trans...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01065-3
更新日期：1995-12-24 00:00:00
abstract：:The current study assessed the influence of excitotoxic lesions of the insular cortex (IC) on taste-potentiated odor aversion (TPOA) learning. Water-deprived rats initially received a single odor-toxicosis or odor/taste-toxicosis pairing and were subsequently tested, in separate trials, with the odor and the taste sti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.051
更新日期：2009-11-10 00:00:00
abstract：:In this research, we investigated striatal neurogenesis in 3-, 6-, 12-, and 18-month-old rats after cerebral ischemic injury. All rats were subjected to a 20-min middle cerebral artery occlusion (MCAO), given 5'-bromodeoxyuridine (BrdU, 30 mg/kg, i.p.) once daily during days 4-7 and sacrificed 2 weeks after MCAO. Neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.043
更新日期：2007-08-29 00:00:00
abstract：:Using cervical sympathectomized and immobilized rabbits, the relationship between the luminance intensity and the magnitude of the response in pupillo-constrictor units of the ciliary nerve was investigated. It was revealed that the intensity--response relationship of the units closely resembled that of retinal recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90787-8
更新日期：1980-11-10 00:00:00
abstract：:The purpose of this study was to determine if motoneurons in the spinal ventral horn express the muscarinic m2 acetylcholine receptor. Motoneurons were retrogradely labelled in adult rats by intramuscular injection of Fluorogold and examined with confocal microscopy for evidence of immunoreactivity for the receptor. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01208-6
更新日期：1999-01-30 00:00:00
abstract：:Generation and persistence of tinnitus following hearing loss may be due to aberrant engagement of attention. Here, functional MRI was used to determine differences in auditory and visual attention processing in adults with tinnitus and hearing loss compared to two age-matched control groups, one with matched hearing ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.05.010
更新日期：2015-09-16 00:00:00
abstract：:A pathway from the pretectal region to the dorsal division of the lateral geniculate body has been studied by autoradiography in adult cats following injection of tritium-labeled amino acids into the meso-diencephalic border zone. The findings suggest that the pretecto-geniculate connection arises in the ipsilateral n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90861-6
更新日期：1980-08-11 00:00:00
abstract：:A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00816-0
更新日期：1997-10-17 00:00:00
abstract：:Albino rats received 10 s of sub-seizure electrical stimulation applied to the dentate gyrus granule cells immediately after acquisition of information on trial 1 of a 2-trial radial maze spatial memory task. Granule cell stimulation selectively reduced the probability of accessing information held in declarative memo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90166-5
更新日期：1984-09-24 00:00:00
abstract：:Venous capacitance plays an important role in the control of cardiac output. However, the central nervous system sites and neurochemical signals involved in modulating venous function remain to be fully elucidated. The hypothalamic paraventricular nucleus (PVN) is an important site modulating autonomic outflow to the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00128-5
更新日期：1997-05-09 00:00:00
abstract：:Following the intraventricular injection of a small amount of [3H]5-hydroxytryptamine ([3H]5-HT), the amount of radioactivity in telencephalic structures on the injected side was 6--7 times larger than that in corresponding areas on the opposite side. Moreover, a multiphasic disappearance of [3H]5-HT from whole brain ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90289-9
更新日期：1975-07-25 00:00:00
abstract：:MicroRNAs (miRNAs) are a class of non-coding small RNAs that regulate the expression of target genes. They derive from pre-miRNAs that are enzymatically processed by dicer to ∼22 nucleotide mature miRNAs. Members of the pre-miRNA lethal-7 (let-7) are known to regulate cell proliferation and apoptosis. Here, we showed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.01.032
更新日期：2018-04-15 00:00:00
abstract：:Fast axonal transport and neuronal protein synthesis was studied in the isolated nervous system of Aplysia californica. The abdominal ganglion with attached pleural-abdominal connectives (PAC) was removed and the ganglion pulse-labelled with [35S]methionine for 30 min in vitro. The axon containing connectives were lig...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90388-9
更新日期：1985-04-15 00:00:00
abstract：:Several studies have demonstrated that the blood-brain barrier (BBB) (dynamic cellular complex composed by brain capillary endothelial cells (BCECs) and surrounded by astrocytic end feet and pericytes) regulates the exchanges of amyloid β (Aβ) peptide between the blood and the brain. Deregulation of these exchanges se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.047
更新日期：2015-01-12 00:00:00
abstract：:Three types of hyperpolarization in response to applied acetylcholine (ACh) were observed in 4 identified neurones (RP1, RP2, RP3 and RP4) in the right parietal ganglion of the African giant snail, Achatina fulica Férussac. In order to clarify the ionic mechanisms of these responses, the neurones were voltage-clamped ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90416-6
更新日期：1986-05-28 00:00:00
abstract：:The pontine respiratory neurons (PRG) in the 'pneumotaxic centre' have been hypothesized to contribute to phase-switching of neural respiratory activity, especially in terminating inspiration. To define the neural elements involved in phase-switching, we recorded respiratory neurons extra- and intracellularly in anest...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91025-1
更新日期：1994-02-14 00:00:00
abstract：:We recorded from the visual cortex of 4 groups of monocularly deprived kittens. Three groups were treated with intraventricular 6-hydroxydopamine (6-OHDA) at different times relative to monocular deprivation (MD). One group received only vehicle solution and MD. 6-OHDA caused the greatest decrease in plasticity in the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90137-4
更新日期：1987-03-01 00:00:00
abstract：:(1) Spontaneous barbiturate spindles were recorded from the primary and secondary somatosensory cortex. The recordings were concentrated to areas surrounding several reference loci. The recording sites producing the maximal response evoked by stimulation of an exposed nerve in a contralateral limb were used as referen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90984-7
更新日期：1976-01-09 00:00:00
abstract：:The measurements of the ion conductances in molluscan somata, published by Connor and Stevens (1971), were converted into Hodgkin-Huxley like equations. The accuracy of these equations was shown with simulations. An advantage of these equations, compared to the original equations for the fast outward K+(A)-conductance...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90120-4
更新日期：1986-09-10 00:00:00
abstract：:The olfactory bulb electroencephalogram (EEG) has been used as a method to imply receptor events12,13. However, experiments to correlate olfactory receptor and bulbar EEG activity in the same species of fish has not been performed. Reported here is the comparison between the simultaneously recorded receptor electroolf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90170-6
更新日期：1982-10-07 00:00:00
abstract：:After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02793-1
更新日期：2000-10-13 00:00:00
abstract：:Alterations in protein phosphorylation may be important in the pathogenesis of Alzheimer's disease and recent observations suggest that a subset of protein kinase pathways may be selectively altered. Calcium/calmodulin-dependent protein kinase II CaM kinase II) is the most abundant protein kinase in the brain and is b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90979-2
更新日期：1994-09-19 00:00:00
abstract：:The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strength...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91311-2
更新日期：1992-10-16 00:00:00
abstract：:Hypothalamus and frontal cortex beta-adrenergic receptors, as measured by [125I]cyanopindolol binding, were investigated in male rats both after 4 days of acute starvation and after 2 weeks of semistarvation with dietary manipulation. Moreover, to test whether lymphocyte beta 2-adrenergic receptors can be used as a ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91519-3
更新日期：1988-03-01 00:00:00
abstract：:More than 50% of the Xenopus pectoralis twitch muscle fibers with two distant endplates are innervated at both sites by the same neuron. This study indicates that there are three separable twitch motor unit types in this muscle which show very little overlap in innervation. This study also shows that each motor unit i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90697-3
更新日期：1985-03-25 00:00:00
abstract：:This work describes the presence of glucocorticoid binding sites in human temporal cortex obtained following partial lobectomy in two epileptic patients. Using [3H]dexamethasone as radioligand and cold cortisol or RU 28362 as competitor we found an apparent Kd of approximately 2.8 nM with a Bmax of approximately 34 fm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91444-8
更新日期：1988-02-23 00:00:00
abstract：:We have previously found that the amyloid precursor protein (APP) of Alzheimer's disease is present on the surface of rat cortical neurons in culture, in a segmental pattern which first becomes evident after 24 hours and is fully developed by five days. As APP has previously been reported to have a short half-life in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00609-9
更新日期：1996-09-30 00:00:00
