Isradipine is able to separate morphine-induced analgesia and place conditioning.


:The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strengthen morphine-induced analgesia as measured by tail-clip and hot-plate tests in mice and tail-clip and tail-flick tests in rats. The results suggest that analgesic and reinforcing effects of morphine might be pharmacologically separated by isradipine.


Brain Res


Brain research


Kuzmin A,Patkina N,Pchelintsev M,Zvartau E




Has Abstract


1992-10-16 00:00:00














  • The influence of chronic stress on multiple opioid peptide systems in the rat: pronounced effects upon dynorphin in spinal cord.

    abstract::Recurrent exposure to intermittent electrical foot-shock (30 min, twice daily) for 7 days caused an increase in immunoreactive (ir) dynorphin and ir-alpha-neo-endorphin in lumbar and cervical (but not thoracic) spinal cord as measured 16 h following the final session. At this time the level of ir-Met-enkephalin-Arg6-G...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Przewlocki R,Lasoń W,Höllt V,Silberring J,Herz A

    更新日期:1987-06-16 00:00:00

  • Histamine restores hemorrhage induced hypotension by activating cholinergic neurons in nucleus tractus solitarius.

    abstract::The purpose of the current study is to investigate the functional connections between the central histaminergic and cholinergic systems at NTS level in hypotensive condition. Experiments were carried out in male Wistar Albino rats. The hypotension was achieved by withdrawing a total volume of 1.5ml blood/100g bodyweig...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Altinbas B,Guvenc G,Erkan LG,Ilhan T,Niaz N,Yalcin M

    更新日期:2016-10-15 00:00:00

  • Hemispheric differences in the number of parvalbumin-positive neurons in subdivisions of the rat basolateral amygdala complex.

    abstract::The amygdala is a bilateral temporal lobe brain region which plays an important role in emotional processing. Past studies on the amygdala have shown hemispheric differences in amygdalar processes and responses associated with specific pain and fear behaviors. Despite the functional differences in the amygdala, few st...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Butler RK,Oliver EM,Fadel JR,Wilson MA

    更新日期:2018-01-01 00:00:00

  • Mg2+ dependence of membrane resistance increases evoked by NMDA in hippocampal neurones.

    abstract::The response of granule cells and CA1 pyramidal neurones to NMDA was studied in the presence and absence of Mg2+ using an in vitro slice preparation. In the absence of Mg2+ the depolarizing response of hippocampal neurones to NMDA is accompanied by a decrease in input resistance. In the presence of Mg2+ ions, however,...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Crunelli V,Mayer ML

    更新日期:1984-10-08 00:00:00

  • Clozapine inhibits micturition parameters and the external urethral sphincter during cystometry in anesthetized rats.

    abstract::Clozapine therapy has been associated with a high degree of urinary disturbances. The purpose of this study is to examine the effect of clozapine on urodynamic parameters and on the activity of the external urethral sphincter in anesthetized rats. Single cystometrograms (CMG) were performed on urethane-anesthetized fe...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vera PL,Nadelhaft I

    更新日期:2001-05-18 00:00:00

  • Differences in forebrain androgen receptor expression in winners and losers of male anole aggressive interactions.

    abstract::Size matched male green anoles (Anolis carolinensis) were paired in a neutral setting and allowed to engage in aggressive displays. Winners and losers were apparent in each pair within 90min, resulting in stable dominant/subordinate dyads. Androgen receptor (AR) expression was assessed at three time points after the i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hattori T,Wilczynski W

    更新日期:2014-09-25 00:00:00

  • Lesions of the accessory olfactory bulb decrease lordotic responsiveness and reduce mating-induced c-fos expression in the accessory olfactory system.

    abstract::The effect of bilateral lesion of the accessory olfactory bulb (AOB) on the mating-induced enhancement of sexual receptivity was investigated in ovariectomized (OVX) female rats. Lesions of the AOB significantly reduced the lordosis-to-mount (L/M) ratio in mating tests conducted 20 to 50 days after the lesion but L/M ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dudley CA,Moss RL

    更新日期:1994-04-11 00:00:00

  • Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat.

    abstract::Experimental studies and clinical observations show that spinal cord lesions are greatly enlarged by a process called secondary cell death. A detailed understanding of the molecular and cellular processes underlying these events is still lacking. In clinical studies using methylprednisolone in spinal cord injured pati...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bartholdi D,Schwab ME

    更新日期:1995-02-20 00:00:00

  • RNA-protein interactions in unstable microsatellite diseases.

    abstract::A novel RNA-mediated disease mechanism has emerged from studies on dominantly inherited neurological disorders caused by unstable microsatellite expansions in non-coding regions of the genome. These non-coding tandem repeat expansions trigger the production of unusual RNAs that gain a toxic function, which involves th...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Mohan A,Goodwin M,Swanson MS

    更新日期:2014-10-10 00:00:00

  • The effect of chronic treatment with a novel aryl-piperazine antipsychotic on monoamine receptors in rat brain.

    abstract::The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shapiro LA,Offord SJ,Ordway GA

    更新日期:1995-04-24 00:00:00

  • Feeding induced by microinjections of NMDA and AMPA-kainate receptor antagonists into ventral striatal and ventral pallidal areas of the pigeon.

    abstract::The participation of glutamatergic circuits of the ventral basal ganglia in feeding-related regulatory mechanisms has been extensively indicated in primate and rodent species. In avian species, it has been shown that ICV injections of MK-801 or of CNQX increase food intake and reduce the latency of feeding initiation ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Da Silva AA,Marino-Neto J,Paschoalini MA

    更新日期:2003-03-14 00:00:00

  • D-serine: the right or wrong isoform?

    abstract::Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine. Therefore, d-seri...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Fuchs SA,Berger R,de Koning TJ

    更新日期:2011-07-15 00:00:00

  • Morphine tolerance and dependence in the nucleus paragigantocellularis: single unit recording study in vivo.

    abstract::In this study, a single unit activity was recorded in the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla of anesthetized, morphine-dependent rats. The spontaneous activity of PGi neurons was significantly decreased by administration of morphine (10 mg/kg; i.p.) in sham-operated, cont...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Haghparast A,Semnanian S,Fathollahi Y

    更新日期:1998-12-14 00:00:00

  • Influence of anaesthetics on rat striatal dopamine metabolism in vivo.

    abstract::The effects of 4 anaesthetics, halothane, alpha-chloralose, chloral hydrate and pentobarbitone, on rat striatal extracellular dihydroxyphenylacetic acid (DOPAC) levels were determined using in vivo voltammetry. Stable baseline levels of DOPAC were maintained under halothane/N2O and alpha-chloralose while the extracell...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ford AP,Marsden CA

    更新日期:1986-07-30 00:00:00

  • Wnt pathway markers in molecular subgroups of glioblastoma.

    abstract::Glioblastoma (GBM) is a highly heterogeneous and aggressive brain tumor. Comprehensive genomic and transcriptomic analyses revealed that GBM segregates into three subgroups with characteristic signaling pathways. The Wnt pathway recently received increasing attention with the recognition of its importance in tumor dev...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tompa M,Nagy A,Komoly S,Kalman B

    更新日期:2019-09-01 00:00:00

  • Pupil dilatation in response to vagal afferent electrical stimulation is mediated by inhibition of parasympathetic outflow in the rat.

    abstract::Pupil dilatation (PD) was produced by vaginocervical mechanical stimulation (VCMS) in intact rats, and in rats with spinal cord (SC) transection at level T7 (i.e., above the level of entry into SC of all genitospinal nerves). After transection of SC, bilateral vagotomy abolished PD in response to VCMS, providing evide...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bianca R,Komisaruk BR

    更新日期:2007-10-26 00:00:00

  • Expression of phenylethanolamine N-methyltransferase in sympathetic neurons and extraadrenal chromaffin tissue of chick embryos in vivo and in vitro.

    abstract::Previous studies suggested the existence of two populations of cells in the mammalian sympathetic nervous system which differ in their ability to express phenylethanolamine N-methyltransferase (PNMT), the enzyme which specifically subserves the biosynthesis of epinephrine: (1) sympathoblasts and their progeny, the nor...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Teitelman G,Skaper S,Baker H,Park DH,Joh TH,Adler R

    更新日期:1984-04-01 00:00:00

  • Conduction velocity varies with osmotically induced changes of the area of the axon's profile.

    abstract::The conduction velocity of frog ischiadic nerves incubated in vitro in osmolarities between 220 and 1000 mOsm decreased with the degree of fiber shrinkage. The latter (non-circularity factor) was determined from computer-assisted measurements in freeze-substituted or in chemically fixed fibers. Freeze-substituted norm...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Minwegen P,Friede RL

    更新日期:1984-04-09 00:00:00

  • Intraocular injection of folate antagonist methotrexate induces neuronal differentiation of embryonic stem cells transplanted in the adult mouse retina.

    abstract::Transplanted embryonic stem (ES) cells can be integrated into the retinas of adult mice as well-differentiated neuronal cells. However, the integrated ES cells also have a tumorigenic effect just because they have the ability for multipotential differentiation to various types of tissues. Thus, control of neoplastic p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hara A,Niwa M,Kumada M,Aoki H,Kunisada T,Oyama T,Yamamoto T,Kozawa O,Mori H

    更新日期:2006-04-26 00:00:00

  • Analysis of anti-depressant potential of curcumin against depression induced male albino wistar rats.

    abstract::The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chang XR,Wang L,Li J,Wu DS

    更新日期:2016-07-01 00:00:00

  • Direct histochemical localisation of 5,7-dihydroxytryptamine and the uptake of serotonin by a subpopulation of GABA neurones in the rabbit retina.

    abstract::The same cells in both the intact retina and retinal cultures of the rabbit retina take up exogenous serotonin or 5,7-dihydroxytryptamine. Both substances can be localised by immunohistochemistry using a monoclonal antibody directed against serotonin. The 5,7-dihydroxytryptamine can also be revealed directly in both f...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Osborne NN,Beaton DW

    更新日期:1986-09-10 00:00:00

  • Effect of morphine on regional cerebral oxygen consumption and supply.

    abstract::The effects of acute opiate receptor stimulation on regional cerebral oxygen consumption and blood flow were examined in 9 regions of the artificially respired, alpha-chloralose-anesthetized cat. Regional cerebral arterial and venous oxygen saturation were examined microspectrophotometrically and regional cerebral blo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Buchweitz E,Grandison L,Weiss HR

    更新日期:1984-01-23 00:00:00

  • Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites.

    abstract::The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction product for detailed analysis in relation to normal cytoarchite...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kruger L,Mantyh PW,Sternini C,Brecha NC,Mantyh CR

    更新日期:1988-11-01 00:00:00

  • Cerebral microvascular responses to endothelins: the role of ETA receptors.

    abstract::The regulatory role of endothelins in cerebral microvessels was investigated in a recently developed model system which allows the study of small cerebral vessels in their normal microenvironment. Using brain slices of the rat neocortex, it was shown that the isopeptide endothelin-3 (ET-3) had no effect on cerebral mi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sagher O,Jin Y,Thai QA,Fergus A,Kassell NF,Lee KS

    更新日期:1994-09-26 00:00:00

  • Vasoactive intestinal polypeptide increases inositol phospholipid breakdown in the rat superior cervical ganglion.

    abstract::The effects of VIP and of peptides of the VIP family: secretin, glucagon, the porcine histidine isoleucine containing peptide (PHI) and the rat hypothalamic growth hormone-releasing hormone (rhGRF) on the cyclic AMP and inositol phosphate contents of isolated rat superior cervical ganglia were investigated. We demonst...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Audigier S,Barberis C,Jard S

    更新日期:1986-06-25 00:00:00

  • IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways.

    abstract::IL-10 reduces pro-inflammatory responses after ischemic stroke primarily by acting on glia and endothelium, but relatively little is known about the direct effects of IL-10 on cortical neurons, which are often damaged in stroke. We found by PCR and immunohistochemistry that cortical neurons express IL-10 receptor. Tre...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sharma S,Yang B,Xi X,Grotta JC,Aronowski J,Savitz SI

    更新日期:2011-02-10 00:00:00

  • Protein tyrosine kinase and mitogen-activated protein kinase activation contribute to K(ATP) and K(ca) channel impairment after brain injury.

    abstract::Previous studies have observed that pial artery dilation to activators of the ATP sensitive K (K(ATP)) and calcium sensitive K (K(ca)) channel was blunted following fluid percussion brain injury (FPI) in the piglet. In recent studies in the rat, protein tyrosine kinase (PTK) activation was observed to contribute to K(...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Armstead WM

    更新日期:2002-07-12 00:00:00

  • Neurotensin increases the cationic conductance of rat substantia nigra dopaminergic neurons through the inositol 1,4,5-trisphosphate-calcium pathway.

    abstract::Whole-cell patch-clamp recordings were used to investigate electrophysiological effects of neurotensin on acutely isolated dopaminergic (DA) neurons of the rat substantia nigra pars compacta (SNC). During current-clamp recordings, neurotensin depolarized DA neurons and triggered action potentials. Under voltage-clamp ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wu T,Li A,Wang HL

    更新日期:1995-06-19 00:00:00

  • Interaction of calmodulin inhibitors and protein kinase C inhibitors with voltage-dependent calcium channels.

    abstract::We compared the relative abilities of a series of calmodulin inhibitors and protein kinase C inhibitors to influence 45Ca2+ influx through voltage-dependent Ca2+ channels in PC12, a clonal neural cell line. K+-depolarization-dependent 45Ca2+ uptake was reduced by the calmodulin inhibitors calmidazolium, trifluoperazin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Greenberg DA,Carpenter CL,Messing RO

    更新日期:1987-02-24 00:00:00

  • A neurotransmitter specific functional recovery mediated by fetal implants in the lesioned spinal cord of the rat.

    abstract::In the electrophysiologic test of the hindlimb withdrawal reflex where the long latency component is found to be dependent on noradrenaline (NA), implants of fetal NA tissue in lesioned animals result in a recovery of NA dependent function proportional to the number of catecholamine fluorescent cells in the implants. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Moorman SJ,Whalen LR,Nornes HO

    更新日期:1990-02-05 00:00:00