Abstract：
:The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strengthen morphine-induced analgesia as measured by tail-clip and hot-plate tests in mice and tail-clip and tail-flick tests in rats. The results suggest that analgesic and reinforcing effects of morphine might be pharmacologically separated by isradipine.
journal_name
Brain Resjournal_title
Brain researchauthors
Kuzmin A,Patkina N,Pchelintsev M,Zvartau Edoi
10.1016/0006-8993(92)91311-2subject
Has Abstractpub_date
1992-10-16 00:00:00pages
221-5issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(92)91311-2journal_volume
593pub_type
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