Tyrosine kinase inhibitors, herbimycin A and lavendustin A, block formation of long-term potentiation in the dentate gyrus in vivo.

abstract：:Cerebellar explants derived from neonatal mice were exposed to cytosine arabinoside, an inhibitor of DNA synthesis. Following such exposure, the cortical regions of the explants contained numerous closely packed large neurons with few intervening elements and without lamination. The surviving large cortical neurons in...

journal_title：Brain research

authors： Seil FJ,Leiman AL,Woodward WR

更新日期：1980-03-31 00:00:00

abstract：:The electrical property of delayed K+ currents (IKD) was studied in pyramidal neurones freshly isolated from the rat hippocampal CA1 region. The IKD was separated pharmacologically from other membrane currents. Activation and inactivation processes of the IKD were highly voltage-dependent in the potential range betwee...

journal_title：Brain research

authors： Oyama Y,Harata N,Akaike N

更新日期：1991-12-24 00:00:00

abstract：:Rats were trained to lever-press for lateral hypothalamic electrical stimulation, and tested following ventral tegmental microinjections of morphine, delta ([D-Pen2,D-Pen5]enkephalin: DPDPE), or kappa (U-50, 488H) receptor agonists or saline. Across the range of effective stimulation frequencies, morphine (8 nmol) and...

journal_title：Brain research

authors： Jenck F,Gratton A,Wise RA

更新日期：1987-10-13 00:00:00

abstract：:The uptake and efflux of 36Cl in the lateral ventricle choroid plexus of 1-7-week-old rats were measured to determine if Cl transport changed with age and if such transport responded to inhibitors of CSF secretion and ion transport. The steady-state (30 min) Cl uptakes were 148 +/- 9.4 nmol.mg-1 dry weight at 1 week a...

journal_title：Brain research

authors： Preston JE,Dyas M,Johanson CE

更新日期：1993-10-08 00:00:00

abstract：:The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcu...

journal_title：Brain research

authors： Chang XR,Wang L,Li J,Wu DS

更新日期：2016-07-01 00:00:00

abstract：:Rats selectively bred for high or low levels of emotionality represent an important and powerful tool to investigate the role of genetic variables in the occurrence of different anxiety disorders. In the present study, albino rats were selectively bred for differences in defensive freezing behavior in response to cont...

journal_title：Brain research

authors： de Castro Gomes V,Landeira-Fernandez J

更新日期：2008-10-03 00:00:00

abstract：:The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 micrograms free base) on 5-HT1B binding sites labeled with S-CM-G-[125I]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surger...

journal_title：Brain research

authors： Manrique C,Segu L,Héry F,Héry M,Faudon M,François-Bellan AM

更新日期：1993-10-01 00:00:00

abstract：:Recently it has been reported that prolactin (PRL) exerts a neuroprotective effect against excitotoxicity in hippocampus in the rat in vivo models. However, the exact mechanism by which PRL mediates this effect is not completely understood. The aim of our study was to assess whether prolactin exerts neuroprotection ag...

journal_title：Brain research

authors： Vergara-Castañeda E,Grattan DR,Pasantes-Morales H,Pérez-Domínguez M,Cabrera-Reyes EA,Morales T,Cerbón M

更新日期：2016-04-01 00:00:00

abstract：:The effects of substantia nigra (SN) stimulation on the activity of the nucleus ventralis lateralis of the thalamus (VL) have been studied. The VL cells were identified as relay or non-relay cells among the cerebellothalamocortical pathway on the basis of orthodromical activation from the cerebellum and antidromical a...

journal_title：Brain research

authors： Deniau JM,Lackner D,Feger J

更新日期：1978-04-21 00:00:00

abstract：:This study investigates the effects of levetiracetam (LEV) on the functional and structural properties of blood-brain barrier (BBB) in pentylenetetrazole (PTZ)-kindled rats with cortical dysplasia (CD). Pregnant rats were exposed to 145 cGy of gamma-irradiation on embryonic day 17. In offsprings, kindling was induced ...

journal_title：Brain research

authors： Gurses C,Ekizoglu O,Orhan N,Ustek D,Arican N,Ahishali B,Elmas I,Kucuk M,Bilgic B,Kemikler G,Kalayci R,Karadeniz A,Kaya M

更新日期：2009-07-24 00:00:00

abstract：:Following injections of WGA-HRP into lower cervical segments, the distribution of anterograde labeled terminals of spinocerebellar fibers was examined in the vermal cortex of the cat. The labeled terminals were seen in sublobules Ib to VIc, VIIb, VIIIa and VIIIb, and lobule IX. They were present mainly in the medial p...

journal_title：Brain research

authors： Matsushita M,Ikeda M,Tanami T

更新日期：1985-12-23 00:00:00

abstract：:Recently, much attention has focused on the role of the melanocortin system in the regulation of energy homeostasis, especially the satiety effects of the pro-opiomelanocortin (POMC)-derived peptide alpha-melanocyte stimulating hormone (alpha-MSH). We have found that POMC mRNA levels are similar in fat and thin sheep ...

journal_title：Brain research

authors： Henry BA,Rao A,Ikenasio BA,Mountjoy KG,Tilbrook AJ,Clarke IJ

更新日期：2001-11-09 00:00:00

abstract：:Axon-to-myelin transfer of lipids precursors have been studied in the rabbit optic system by intraocular injection of [32P]orthophosphate, [14C]glycerol and [3H]glycerol. Choline and ethanolamine phosphoglycerides and myelin showed increasing [32P]-radioactivity between 7 and 21 days following injection, while [3H]- a...

journal_title：Brain research

authors： Ledeen RW,Haley JE

更新日期：1983-06-20 00:00:00

abstract：:Combined amylin+leptin (AMN+LEP) can reduce diet induced obesity and is very effective in combating LEP resistance. The purpose of this study was to evaluate the effect of AMN+LEP on central histaminergic signaling in lean and obese rats. Male rats were administered LEP (300 μg/kg/d), AMN (100 μg/kg/d), AMN+LEP or veh...

journal_title：Brain research

authors： Seth R,Terry DE,Parrish B,Bhatt R,Overton JM

更新日期：2012-03-09 00:00:00

abstract：:Hepatocyte growth factor (HGF/SF), is a heparin-binding polypeptide which stimulates DNA synthesis in a variety of cell types and also promotes cell migration and morphogenesis. HGF/SF mRNA has been found in a variety of tissues, including brain. In a previous study, we showed that basic fibroblast growth factor (bFGF...

journal_title：Brain research

authors： Fenton H,Finch PW,Rubin JS,Rosenberg JM,Taylor WG,Kuo-Leblanc V,Rodriguez-Wolf M,Baird A,Schipper HM,Stopa EG

更新日期：1998-01-01 00:00:00

abstract：:The origins of nitric oxide synthase (NOS)-containing nerve fibers in the rat basilar artery were studied by a combination of Fluoro-Gold retrograde tracing and immunohistochemistry. After application of Fluoro-Gold onto the middle part of the basilar artery, the dye accumulated in the sphenopalatine, otic, trigeminal...

journal_title：Brain research

authors： Kadota O,Matsuda S,Ohta S,Kumon Y,Sakaki S,Sakanaka M

更新日期：1996-01-08 00:00:00

abstract：:Somatostatin (SRIF) receptors are expressed in the external granule cell layer of the rat cerebellum during early postnatal life. The aim of the present study was to investigate the distribution and biochemical characteristics of SRIF binding sites in the cerebellum of homozygous (vasopressin deficient) Brattleboro ra...

journal_title：Brain research

authors： Gonzalez BJ,Leroux P,Boer GJ,Vaudry H

更新日期：1990-11-05 00:00:00

abstract：:The dipeptide N-acetylaspartylglutamate (NAAG) may be involved in the process of glutamatergic signaling by both acting at glutamate receptors and as a glutamate protransmitter. In the present study we determined the cellular localization and distribution of NAAG-like immunoreactivity (NAAG-LI) in normal human brain a...

journal_title：Brain research

authors： Passani LA,Vonsattel JP,Coyle JT

更新日期：1997-10-24 00:00:00

abstract：:These experiments were conducted in order to better understand the role of catecholaminergic neurons in intracranial self-stimulation behaviour (ICSS) elicited from the lateral hypothalamus (LH). Two strains of mice which differ in their ICSS rate and their thresholds were studied. In a first time, we compared the cat...

journal_title：Brain research

authors： Garrigues AM,Cazala P

更新日期：1983-04-18 00:00:00

abstract：:Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O(2)) or intermittent hypoxia (IH; 10% and ...

journal_title：Brain research

authors： Li RC,Lee SK,Pouranfar F,Brittian KR,Clair HB,Row BW,Wang Y,Gozal D

更新日期：2006-06-22 00:00:00

abstract：:Steps of torque were applied to the human forearm during intentional flexion movements with peak velocities of 40-500 degrees/sec and during ballistically initiated flexion movements. The question asked was whether or not the motor ouput to both agonist and antagonist muscles is independent of sensory input data or is...

journal_title：Brain research

authors： Dufresne JR,Gurfinkel VS,Soechting JF,Terzuolo CA

更新日期：1978-07-07 00:00:00

abstract：:Transgenic mice expressing human APPswe and PS1-A264E mutations mimic certain neuropathological features of Alzheimer's disease (AD). These mice have elevated levels of the highly fibrillogenic amyloid beta1-42 peptide (Abeta42) and develop amyloid plaques around the age of 9 months. Our aim was to find whether these ...

journal_title：Brain research

authors： Wang J,Ikonen S,Gurevicius K,van Groen T,Tanila H

更新日期：2002-07-12 00:00:00

abstract：:Aspartate-immunoreactivity (ir) was examined in the mouse trigeminal ganglion (TG). The ir was detected in 34% of TG neurons and their cell bodies were of various sizes (mean +/- S.D. = 1,234 +/- 543 microm(2)). A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related pep...

journal_title：Brain research

authors： Ichikawa H,Matsuo S,Terayama R,Yamaai T,Sugimoto T

更新日期：2006-04-12 00:00:00

abstract：:A site-specific antibody against the principal gap junctional protein in heart (connexin 43) was used to determine immunohistochemically the cellular localization of this protein in rat brain. Structures labelled with the antibody included gap junctional membranes between glial, ependymal, pial and arachnoid cells as ...

journal_title：Brain research

authors： Yamamoto T,Ochalski A,Hertzberg EL,Nagy JI

更新日期：1990-02-05 00:00:00

abstract：:The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...

journal_title：Brain research

authors： Furlong T,Carrive P

更新日期：2007-01-12 00:00:00

abstract：:A study has been made of the effects of a series of excitatory amino acid receptor antagonists on the field potentials evoked on electrical stimulation of the lateral olfactory tracts of olfactory cortex slices perfused in vitro. The antagonists studied included (+/-)-2-amino-5-phosphonovaleric acid, a potent, specifi...

journal_title：Brain research

authors： Collins GG

更新日期：1982-07-29 00:00:00

abstract：:The nucleus of the solitary tract (NTS) is a critical structure involved in coordinating autonomic and visceral activities. Previous independent studies have demonstrated efferent projections from the NTS to the nucleus paragigantocellularis (PGi) and the central nucleus of the amygdala (CNA) in rat brain. To further ...

journal_title：Brain research

authors： Reyes BA,Van Bockstaele EJ

更新日期：2006-10-30 00:00:00

abstract：:Intraventricular injections of carbachol, a cholinergic agonist, into free-running mice can cause phase dependent phase shifts, in both directions, in the circadian rhythm of wheel-running activity. These effects mimic the action of light in entraining the circadian pacemaker, and suggest that acetylcholine may play a...

journal_title：Brain research

authors： Zatz M,Herkenham MA

更新日期：1981-05-11 00:00:00

abstract：:The rostral projection of A delta and C primary afferents in Lissauer's tract (LT) was studied by assessing how far, rostrally, axons entering at a given level could be activated by electrical stimulation. Sural A delta primary afferents in LT exhibited a rostral projection at least as far as the L3/L4 border, 4 segme...

journal_title：Brain research

authors： Traub RJ,Sedivec MJ,Mendell LM

更新日期：1986-12-03 00:00:00

abstract：:The retrogradely-transported tracer, rhodamine-tagged microspheres was injected into the pressor region of the rostral ventrolateral medulla (RVLM) to enable detection of paraventricular neurons in the hypothalamus that project to the RVLM. The protein, Fos, was detected immunohistochemically and used to highlight neu...

journal_title：Brain research

authors： Badoer E

更新日期：1998-08-10 00:00:00