Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain.


:Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O(2)) or intermittent hypoxia (IH; 10% and 21% O(2) alternating every 90 s) for 1, 3, 7 and 14 days, and mRNA and protein expression of Ngb and Cygb were assessed in brain cortex. SH increased Ngb mRNA and protein expression throughout the exposure, while IH only elicited slight increases in Ngb expression at day 1. Neither SH nor IH elicited increases in Cygb expression. Thus, hypoxic stimulus presentation is a major determinant of the regulation of hypoxic sensitive genes such as Ngb. Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain.


Brain Res


Brain research


Li RC,Lee SK,Pouranfar F,Brittian KR,Clair HB,Row BW,Wang Y,Gozal D




Has Abstract


2006-06-22 00:00:00














  • Supporting evidence for negative modulation by protons of an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain using ligand binding techniques.

    abstract::The addition of L-glutamic acid (Glu) alone, both Glu and glycine (Gly) or Glu/Gly/spermidine (SPD) was effective in potentiating [3H]5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding before equilibrium to an ion channel associated with the N-methyl-D-aspartate (NMDA) receptor complex in b...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yoneda Y,Enomoto R,Ogita K

    更新日期:1994-02-14 00:00:00

  • Synaptic transmission and paired-pulse behaviour of CA1 pyramidal cells in hippocampal slices from a hibernator at low temperature: importance of ionic environment.

    abstract::To investigate the effects of ionic changes possibly associated with hibernation, hippocampal slices prepared from golden hamsters were studied in artificial cerebrospinal fluid (ACSF) of variable composition (K+ 3-5 mM, Ca2+ 2-4 mM, Mg2+ 2-4 mM, pH 7.0-7.7) at temperatures of 15-20 degrees C, just above the temperatu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Igelmund P,Heinemann U

    更新日期:1995-08-14 00:00:00

  • Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase within the vertebrate retina.

    abstract::Histochemical and immunochemical techniques are used to locate 2',3'-cyclic nucleotide-3'-phosphohydrolase (2',3'-cNMP-3'ase) within cells of the vertebrate retina. A new histochemical method is described which links the hydrolysis of 2',3'-cNADP to the formation of a reduced, insoluble tetrazolium formazan. Photorece...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Giulian D,Iwanij V,Dean G,Drummond RJ

    更新日期:1983-04-18 00:00:00

  • Decreased dopamine type 2 receptor availability after bariatric surgery: preliminary findings.

    abstract:BACKGROUND:Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dunn JP,Cowan RL,Volkow ND,Feurer ID,Li R,Williams DB,Kessler RM,Abumrad NN

    更新日期:2010-09-02 00:00:00

  • Target cues are not required for the guidance of sympathetic preganglionic axons.

    abstract::The patterns of preganglionic projections in the avian sympathetic system are highly specific. Preganglionic axons arising from the T1 spinal segment, for example, project predominantly in the rostral direction, whereas T4 preganglionic axons project predominantly in the caudal direction. Moreover, each ganglion recei...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yip JW

    更新日期:1987-03-01 00:00:00

  • AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis.

    abstract::It has been well established that the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) opener, diazoxide, has protective effects on the heart and brain following ischemia/reperfusion injury. However, the mechanism of the neuroprotective effects of diazoxide remains unclear. This study highlights the anti-apo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang H,Wang ZQ,Zhao DY,Zheng DM,Feng J,Song LC,Luo Y

    更新日期:2011-01-25 00:00:00

  • Interleukin-1 (IL-1) stimulates arginine vasopressin (AVP) release from superfused rat hypothalamo-neurohypophyseal complexes independently of cholinergic mechanism.

    abstract::We studied whether interleukin-1 (IL-1) affects the release of arginine vasopressin (AVP) from the superfused hypothalamo-neurohypophyseal complex (HNC) of rats. Involvement of the cholinergic system in the mediation of IL-1 on AVP release from HNC was also examined. Both human recombinant IL-1 alpha and -1 beta elici...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nakatsuru K,Ohgo S,Oki Y,Matsukura S

    更新日期:1991-07-19 00:00:00

  • Cholinotoxic effects of beta-amyloid (1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis.

    abstract::Beta-amyloid(1-42) peptide (betaAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral f...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Harkany T,Lengyel Z,Soós K,Penke B,Luiten PG,Gulya K

    更新日期:1995-10-09 00:00:00

  • Stimulation of the gerbil's gustatory receptors by polyols.

    abstract::The gustatory responses of the Mongolian gerbil were tested with 12 sugar alcohols. The electrophysiological effectiveness of the linear polyols as gustatory stimulants increased as the length of the carbon chain increased from 2 to 5. Six and 7 carbon acyclic polyols were no more effective than the pentitols. By comp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jakinovich W Jr,Oakley B

    更新日期:1976-07-16 00:00:00

  • Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process.

    abstract::Expression of the protein products of the immediate-early genes (IEGs), members of the fos, jun and krox families (Jun, Fos, and Krox, resp.) was investigated in the spinal cord and sensory ganglia (DRG) of normal rats; and following transection of, block of axonal transport in, or electrical stimulation of their peri...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Leah JD,Herdegen T,Bravo R

    更新日期:1991-12-06 00:00:00

  • Response properties of units in the lateral geniculate nucleus of the domestic chick (Gallus domesticus).

    abstract::One hundred and four visual units of the (ventral) lateral geniculate nucleus (GL) of chicks (Gallus domesticus) were studied with extracellular microelectrodes. Most were extremely responsive to moving targets even at low speeds (0.1 degrees/sec). They were classified as follows. (1) movement-sensitive units with uni...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pateromichelakis S

    更新日期:1979-05-11 00:00:00

  • MiR-105 and miR-9 regulate the mRNA stability of neuronal intermediate filaments. Implications for the pathogenesis of amyotrophic lateral sclerosis (ALS).

    abstract::Intermediate filament aggregation within motor neurons is a hallmark of ALS pathogenesis. Changes to intermediate filament stoichiometry due to altered mRNA steady-state levels of NEFL, PRPH and INA is thought to drive protein aggregation, yet the exact cause of these changes is unknown. MicroRNAs (miRNAs)-master regu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hawley ZCE,Campos-Melo D,Strong MJ

    更新日期:2019-03-01 00:00:00

  • Aging masks detection of radiation-induced brain injury.

    abstract::Fractionated partial or whole-brain irradiation (fWBI) is a widely used, effective treatment for primary and metastatic brain tumors, but it also produces radiation-induced brain injury, including cognitive impairment. Radiation-induced neural changes are particularly problematic for elderly brain tumor survivors who ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shi L,Olson J,D'Agostino R Jr,Linville C,Nicolle MM,Robbins ME,Wheeler KT,Brunso-Bechtold JK

    更新日期:2011-04-18 00:00:00

  • Dissociation of IGF2 and H19 imprinting in human brain.

    abstract::The human IGF2 and H19 genes are imprinted in most normal tissues. Alterations of genomic imprinting or loss of imprinting (LOI) have been observed in a number of malignant tumors. Although LOI has been linked to tumorigenesis, loss of IGF2 imprinting has also been observed in choroid plexus and leptomeninges in norma...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pham NV,Nguyen MT,Hu JF,Vu TH,Hoffman AR

    更新日期:1998-11-09 00:00:00

  • Increase in coronary vascular resistance produced by stimulating neurons in the region of the area postrema of the cat.

    abstract::Recently, Somberg, in a preliminary report (1983), noted that electrical stimulation of the area postrema causes an increase in coronary vascular resistance. The increase in resistance was mediate by an increase in sympathetic activity as it was counteracted by alpha-adrenergic receptor blockade. The purpose of our st...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gatti PJ,Dias Souza J,Gillis RA

    更新日期:1988-05-17 00:00:00

  • Neural correlates of acoustic reasoning.

    abstract::We report an fMRI experiment on deductive reasoning with acoustically presented problems. Twelve volunteers received problems in which an acoustic stimulus came from the left or the right of another stimulus. The participants then heard a third stimulus coming from the left or the right of one of the proceeding stimul...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fangmeier T,Knauff M

    更新日期:2009-01-16 00:00:00

  • Synaptic amplification by active membrane in dendritic spines.

    abstract::The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem re...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Miller JP,Rall W,Rinzel J

    更新日期:1985-01-28 00:00:00

  • In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease.

    abstract::Type 1 cannabinoid (CB1) receptors are expressed in high concentrations in the central nervous system, including the basal ganglia, and could have direct or indirect effects on motor behavior through modulation of dopaminergic, glutamatergic and GABA-ergic neurotransmission. Using the CB1 receptor radioligand [(18)F]M...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Casteels C,Lauwers E,Baitar A,Bormans G,Baekelandt V,Van Laere K

    更新日期:2010-02-26 00:00:00

  • Plectin immunopositivity appears in the astrocytes in the white matter but not in the gray matter after stab wounds.

    abstract::Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kálmán M,Szabó A

    更新日期:2000-02-28 00:00:00

  • Tyrosine hydroxylase, aromatic L-amino acid decarboxylase and dopamine metabolism after chronic treatment with dopaminergic drugs.

    abstract::Mice were treated with dopamine (DA) receptor agonist and antagonist drugs: Agonists: (+/-)-SKF 38393 ((+/-)-1-phenyl-2,3,4, 5-tetrahydro-(1H)-3-benzazepine-7,8-diol) [DA D1-like]; bromocriptine, [DA D2 selective]; quinpirole, [DA D2/D3 preferring]; (+/-)-7-hydroxy-dipropylamino-tetralin (7-OH-DPAT), [DA D3/D2 preferr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cho S,Duchemin AM,Neff NH,Hadjiconstantinou M

    更新日期:1999-06-05 00:00:00

  • Laminar distribution of non-principal neurons in the rat hippocampus, with special reference to their compositional difference among layers.

    abstract::In the present study we examined the laminar distributions of four types of chemically defined subpopulations of non-principal neurons, that is, those immunoreactive for parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and somatostatin (SS), in the rat hippocampus, by estimating their approximate numeric...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nomura T,Fukuda T,Aika Y,Heizmann CW,Emson PC,Kobayashi T,Kosaka T

    更新日期:1997-08-01 00:00:00

  • Quantitative analysis of axon collaterals of single superficial pyramidal cells in layer IIb of the piriform cortex of the guinea pig.

    abstract::To understand the functional organization of the piriform cortex (PC), the axon collaterals of three pyramidal cells in layer IIb of the anterior PC and one pyramidal cell in layer IIb of the posterior PC were labeled and quantitatively analyzed by intracellular biocytin injection in the guinea pig. Single pyramidal c...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: ul Quraish A,Yang J,Murakami K,Oda S,Takayanagi M,Kimura A,Kakuta S,Kishi K

    更新日期:2004-11-05 00:00:00

  • Alterations in striatal zif/268, preprodynorphin and preproenkephalin mRNA expression induced by repeated amphetamine administration in rats.

    abstract::Quantitative in situ hybridization histochemistry was used to compare the effects of AMPH administration on mRNAs coding for zif/268, a member of the zinc finger family of immediate early genes, and the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in rat striatum after 3 dosing schedules: (1) acu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wang JQ,McGinty JF

    更新日期:1995-03-06 00:00:00

  • Short toxic methamphetamine schedule impairs object recognition task in male rats.

    abstract::Performance on object recognition and object placement memory tasks was evaluated after a short-dosing model of methamphetamine (MA) regime and monoamines and metabolites were measured post-testing. Adult male rats received three injections of 10 mg/kg at 2-h intervals. In striatum DA and 5-HT were depleted by 65% and...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bisagno V,Ferguson D,Luine VN

    更新日期:2002-06-14 00:00:00

  • How are the motor system activity and functional connectivity between the cognitive and sensorimotor systems modulated by athletic expertise?

    abstract::Expertise offers a unique insight into how our brain functions. The purpose of this experiment was to determine if motor system activity and functional connectivity between the cognitive system and sensorimotor system is differentially modulated by an individual's level of expertise. This goal was achieved through the...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tomasino B,Maieron M,Guatto E,Fabbro F,Rumiati RI

    更新日期:2013-12-02 00:00:00

  • Therapeutic effects of erythropoietin on histological and functional outcomes following traumatic brain injury in rats are independent of hematocrit.

    abstract::Erythropoietin (EPO) provides neuroprotection and neurorestoration after traumatic brain injury (TBI). The EPO doses used for treatment of TBI significantly increase hematocrit, which may affect the efficacy of EPO therapy for TBI. The aim of this study was to investigate whether normalization of hematocrit would affe...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang Y,Xiong Y,Mahmood A,Meng Y,Qu C,Schallert T,Chopp M

    更新日期:2009-10-19 00:00:00

  • The effect of acute kainic acid treatment on mu-opioid receptors in rat brain.

    abstract::There is evidence that acute exposure to kainic acid (KA) induces the release of endogenous ligands for opioid receptors and that mu-opioid agonists intensify KA-induced neurodegeneration. The aim of the present study was to investigate any acute toxic effects of KA upon mu-opioid receptors labelled with [3H]-DAMGO. 2...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ridd MJ,Fosbraey P,Kitchen I

    更新日期:1998-12-14 00:00:00

  • Prefrontal unit activity and delayed response: relation to cue location versus direction of response.

    abstract::Two monkeys were trained to perform 3 kinds of spatial tasks (right-left DR, up-down DR, and conditional position discrimination with delay). In the conditional position task, the animal was required to respond to the right (left) choice key when the cue had been presented on the upper (lower) position. Single unit ac...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Niki H,Watanabe M

    更新日期:1976-03-19 00:00:00

  • Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice.

    abstract::The aim of the present study was to elucidate the effects of granulocyte colony-stimulating factor (G-CSF)-mediated mobilization of bone marrow-derived stem cells on the injured spinal cord. Bone marrow cells of green fluorescent protein (GFP) transgenic mice were transplanted into lethally irradiated C57BL/6 mice. Fo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Koda M,Nishio Y,Kamada T,Someya Y,Okawa A,Mori C,Yoshinaga K,Okada S,Moriya H,Yamazaki M

    更新日期:2007-05-29 00:00:00

  • Neuropeptide Y-immunoreactive neurons receive synaptic inputs from dopaminergic axon terminals in the rat neostriatum.

    abstract::Double immunocytochemistry using peroxidase-antiperoxidase and protein A-gold was performed to determine whether neuropeptide Y (NPY) immunoreactive neurons receive synaptic inputs from catecholaminergic axon terminals in the rat neostriatum. Tyrosine hydroxylase-immunoreactive axons were found to be in synaptic conta...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kubota Y,Inagaki S,Kito S,Shimada S,Okayama T,Hatanaka H,Pelletier G,Takagi H,Tohyama M

    更新日期:1988-08-23 00:00:00