Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain.

Abstract:

:Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O(2)) or intermittent hypoxia (IH; 10% and 21% O(2) alternating every 90 s) for 1, 3, 7 and 14 days, and mRNA and protein expression of Ngb and Cygb were assessed in brain cortex. SH increased Ngb mRNA and protein expression throughout the exposure, while IH only elicited slight increases in Ngb expression at day 1. Neither SH nor IH elicited increases in Cygb expression. Thus, hypoxic stimulus presentation is a major determinant of the regulation of hypoxic sensitive genes such as Ngb. Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain.

journal_name

Brain Res

journal_title

Brain research

authors

Li RC,Lee SK,Pouranfar F,Brittian KR,Clair HB,Row BW,Wang Y,Gozal D

doi

10.1016/j.brainres.2006.04.063

subject

Has Abstract

pub_date

2006-06-22 00:00:00

pages

173-9

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(06)01115-2

journal_volume

1096

pub_type

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