Abstract:
:Growth hormone (GH) suppresses its own secretion by stimulating somatostatin (SRIF) release. Thus, the possible regulation of GH-releasing factor (GRF) and SRIF release and SRIF messenger ribonucleic acid (mRNA) by GH was studied in the hypothalamus of male rats in vitro. The median eminences (ME's) were incubated in buffer containing 10(-7)-10(-11) M GH for 30 min. SRIF and GRF released into the medium were quantitated by RIA. The release of SRIF from ME fragments was significantly increased (P < 0.001) by 10(-9) M GH; however, 10(-9) M GH also inhibited (P < 0.01) GRF release from the ME. To determine the effect of GH on SRIF mRNA levels, periventricular nucleus (PeN) explants were cultured during 6 h in medium with 10(-7)-10(-11) M GH. Levels of SRIF mRNA (determined by an S1 nuclease protection assay) were significantly elevated in the presence of 10(-10)-10(-7) M GH. Likewise, 10(-9) M GH significantly stimulated SRIF release from PeN explants at 30 min and at 6 h. Surprisingly, 10(-9) M GH also significantly increased GRF release from the PeN explants at these times as well. This GRF was not responsible for the increased SRIF release or SRIF mRNA induced by GH since GRF antibody did not modify the GH-induced increases in SRIF release and mRNA levels. These results demonstrate a negative short-loop feedback of GH mediated at the ME by suppression of GRF and stimulation of SRIF release, whereas in the PeN GH increased both SRIF release and SRIF mRNA levels.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Aguila MC,McCann SMdoi
10.1016/0006-8993(93)90014-esubject
Has Abstractpub_date
1993-09-24 00:00:00pages
89-94issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(93)90014-Ejournal_volume
623pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neuron...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.109
更新日期:2006-08-23 00:00:00
abstract::Awake, intact monkeys were trained to perform discrete flexion or extension movements of the hand about the wrist in response to visual signals. The object of the movement was to align a cursor, coupled to a manipulandum, on a target line. Cursor and target lines are displayed on a video monitor placed in front of the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90726-0
更新日期:1982-03-25 00:00:00
abstract::Alteration of blood-brain barrier (BBB) permeability by 2450 MHz CW microwaves was assessed semi-quantitatively after intravenous injection of horseradish peroxidase (HRP) and exposure of conscious, unrestrained rats to incident power densities of 0, 20 or 65 mW/cm2 for 30, 90 or 180 min. Additional rats were exposed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-0173(84)90022-5
更新日期:1984-05-01 00:00:00
abstract::Odor stimulation of the nose in the box turtle and the gopher tortoise produced a characteristic series of slow potentials in the olfactory bulb which were referred to as the odor evoked response. When recorded with direct coupling, the odor evoked response had 3 components: wave I, a short duration monophasic event; ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90914-2
更新日期:1975-10-24 00:00:00
abstract::In rats anaesthetised with alphaxalone/alphadolone, electrical stimulation in the dorsolateral part of the periaqueductal grey matter (PAG; 10 s trains of 1 ms pulses at 80 Hz, 40-80 microA) evoked a pressor response accompanied by tachycardia. Both components of the response were attenuated following microinjection o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90702-1
更新日期:1994-07-18 00:00:00
abstract::Ibogaine, an indolalkylamine, has been proposed for use in treating stimulant addiction. In the present study we sought to determine if ibogaine had any effects on the neurochemical and motor changes induced by D-amphetamine that would substantiate the anti-addictive claim. Ibogaine (40 mg/kg, i.p.) injected 19 h prio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90745-u
更新日期:1992-05-01 00:00:00
abstract::Experiments were performed to test the hypothesis that subarachnoid hemorrhage (SAH) causes functionally relevant perturbations of cyclooxygenase activity in cerebral arteries. Four groups of rabbits were formed: (I) controls; (II) sham injected animals (2 ml physiological solution in the cisterna magna); (III) SAH gr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00053-5
更新日期:1998-04-20 00:00:00
abstract::"Dystrophic' mice of the 129/ReJ-Dy strain have a genetic defect affecting Schwann cell proliferation. Spinal nerve roots of these animals contain myelinated and unmyelinated axons in addition to groups of large "amyelinated' axons. In affected regions of the spinal roots, myelinated axons are missing their myelin she...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91116-1
更新日期:1981-11-09 00:00:00
abstract::Infusions of angiotensin II (AII) or carbachol (CBC) into the lateral ventricles of rats which had been depleted of sodium 4 h previously with either furosemide or polyethylene glycol produced significant changes in salt appetite and sodium and water balances relative to rats infused with saline vehicle. Infusions of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90860-1
更新日期:1985-11-04 00:00:00
abstract::Data from several laboratories indicate that cerebral endothelial cells possess cell surface receptors for numerous vasoactive agents including angiotensin II (AII) and atrial natriuretic factor (ANF). The intracellular messengers of these receptors as well as possible receptor interactions were explored. ANF increase...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91191-3
更新日期:1991-10-18 00:00:00
abstract::A sample of 302 neurons in rat hindlimb granular cortex was studied between 2 and 3 weeks after transection and ligation of the sciatic nerve. These neurons were compared to a control sample obtained from normal rats under similar experimental conditions. After sciatic nerve transection the proportion of neurons drive...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91019-0
更新日期:1988-05-24 00:00:00
abstract::Immunocytochemistry and high-performance liquid chromatography with electrochemical detection (HPLC-ED) were used, more than 76 days after infraorbital nerve (ION) transection, to examine the distribution and density of serotonin-immunoreactive (5-HTIR) axons, as well as serotonin (5-HT) and 5-hydroxyindoleacetic acid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90040-i
更新日期:1990-12-17 00:00:00
abstract::A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91641-6
更新日期:1987-12-29 00:00:00
abstract::The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90016-2
更新日期:1987-09-01 00:00:00
abstract::Thermoregulatory (brown adipose tissue temperature) experiments were conducted in age-matched anesthetized, male Sprague-Dawley and Long Evans rats kept at 37 degrees C given unilateral electrical stimulation of the ventromedial hypothalamic nucleus or the lateral preoptic area or after intravenous infusion of norepin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90422-6
更新日期:1992-03-13 00:00:00
abstract::We used triple-labeling immunohistochemistry in rat midbrain sections to identify dopaminergic neurons that contain either one or both of the calcium-binding proteins, calretinin (CR) and calbindin-D28k (CB). Midbrain dopaminergic neurons were immunohistochemically labeled for tyrosine hydroxylase (TH), CR, and CB. In...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01950-2
更新日期:1999-10-30 00:00:00
abstract::The synaptic regulatory mechanism of resting membrane potential of layer III and V pyramidal neurons was analyzed intracellularly in the slice preparation of cat sensorimotor cortex. During the tetanic stimulation of white matter, subthreshold membrane depolarization was induced, and after that, a slowly developing hy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02353-2
更新日期:2000-06-30 00:00:00
abstract::Animal models of cerebral infarction are crucial to understanding the mechanisms of neuronal survival following ischemic brain injury and to the development of therapeutic interventions for victims of all types of stroke. Rodents have been used extensively in such research. One rodent model of stroke utilizes either p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.02.021
更新日期:2005-04-25 00:00:00
abstract::A possible functional relationship between corticotropin-releasing factor (CRF) and opiate peptide neuronal systems (beta-endorphin, dynorphin1-17 and Met-enkephalin) and their interactions with gonadotropin releasing hormone (GnRH) in the mesencephalic central gray (MCG) for the regulation of lordosis behaviour was a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90414-7
更新日期:1985-06-10 00:00:00
abstract::Acute hyperammonemia is associated with motor disturbances that are thought to involve striatal dopaminergic dysfunction. Discharge of striatal dopaminergic neurons is controlled by N-methyl-D-aspartate (NMDA) receptors, the excessive activation of which contributes to ammonia neurotoxicity. Here we show that ammonium...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02777-x
更新日期:2003-07-11 00:00:00
abstract::The nictitating membrane response to periocular electrostimulation was investigated in anesthetized and paralyzed rabbits. Recordings from the abducens nerve, which carries the fibers innervating retractor bulbi muscles that are primarily involved in this reflex, showed two distinct volleys to effective stimulation: a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91143-5
更新日期:1983-01-10 00:00:00
abstract::Effects of intracranial self-stimulation of central 'punishment areas' were studied on an operant conditioning of vertical eye movements in the midpontine pretrigeminal cats as well as in the encéphale isolé cats. In 36 pretrigeminal cats, the ventromedial hypothalamus (VMH), basal amygdaloid nuclei (AMY), dorsal cent...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91008-8
更新日期:1981-12-21 00:00:00
abstract::The focal ischemia obtained in an animal model of middle cerebral artery occlusion (MCAo) causes the "core" of damage in the striatum and the "penumbra" of damage in the fronto-parietal cortex. The latter is mainly functionally affected and shows changes in nNOS and iNOS expression during the acute phase of ischemia. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.029
更新日期:2007-02-09 00:00:00
abstract::The effects of midazolam, one of the most popular benzodiazepines, on synaptic transmissions were compared with intracellular recordings between CA1 pyramidal cells (CA1-PCs) and dentate gyrus granule cells (DG-GCs) in rat hippocampal slices. First, we studied the effects of midazolam on orthodromically evoked spikes,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00920-7
更新日期:1997-10-31 00:00:00
abstract::The neurophysiological correlates of autoinhibition at the terminals of nigrostriatal dopaminergic neurons were studied by measuring the changes in antidromic excitability of nigrostriatal neurons following local infusions of various catecholamine agonists and antagonists into the neostriatum. Infusions of apomorphine...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1984-09-10 00:00:00
abstract::The effect of haloperidol administration on lipid peroxidation and glutathione/protein thiol homeostasis in the brain was examined 4 h following subcutaneous administration of a single dose of haloperidol; 1.0, 1.5, 2.0 or 2.5 mg/kg b.wt. Glutathione (GSH) levels decreased significantly in cortex, striatum and midbrai...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91058-m
更新日期:1992-11-13 00:00:00
abstract::Serotonin 1A receptor (5-HT(1A)R) agonists have emerged as valuable supplements to l-DOPA therapy, demonstrating that they can decrease side effects and enhance motor function in animal models of Parkinson's disease (PD) and human PD patients. The precise mechanism by which these receptors act remains unknown and ther...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.05.005
更新日期:2007-07-16 00:00:00
abstract::Norepinephrine (NE), acting on brain adrenoceptors, plays an important role in barrel field neuronal activity and plasticity. For this reason, the distribution of alpha 1- and alpha 2-adrenoceptors in the somatosensory cortex barrel field was studied by autoradiographic techniques in rats undergoing plastic change or ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90005-8
更新日期:1993-09-24 00:00:00
abstract::The influence of the inhibitory transmitter gamma-aminobutyric acid (GABA) on depolarizations elicited by the excitatory amino acid N-methyl-D-aspartate (NMDA) was tested in neurons of organotypic neocortical tissue cultures (newborn rat) and in CA3 neurons of the hippocampal slice (guinea pig). Drugs were applied thr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90737-v
更新日期:1990-02-26 00:00:00
abstract::The time course of the neurogenesis of cells showing glutamic acid decarboxylase (GAD) immunoreactivity has been analyzed in the dorsal hippocampus and area dentata of the mouse. The quantitative data indicate that gamma-aminobutyric acid (GABA)ergic cells are generated prenatally, and that their peaks of neurogenesis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(86)80012-9
更新日期:1986-11-01 00:00:00