Abstract：
:Ibogaine, an indolalkylamine, has been proposed for use in treating stimulant addiction. In the present study we sought to determine if ibogaine had any effects on the neurochemical and motor changes induced by D-amphetamine that would substantiate the anti-addictive claim. Ibogaine (40 mg/kg, i.p.) injected 19 h prior to a D-amphetamine challenge (1.25 mg/kg, i.p.) potentiated the expected rise in extracellular dopamine levels in the striatum and in the nucleus accumbens, as measured by microdialysis in freely moving rats. Using photocell activity cages, the same ibogaine pretreatment enhanced the stimulatory motor effects induced by a wide range of D-amphetamine doses (0.625, 1.25, 2.5 or 5 mg/kg, i.p.). These findings suggest that ibogaine might increase the reinforcing efficacy of D-amphetamine. However, since high doses of D-amphetamine can be aversive, the potentiation of D-amphetamine's effects by ibogaine might also lead to a decrease in the reinforcing efficacy of D-amphetamine.
journal_name
Brain Resjournal_title
Brain researchauthors
Maisonneuve IM,Keller RW Jr,Glick SDdoi
10.1016/0006-8993(92)90745-usubject
Has Abstractpub_date
1992-05-01 00:00:00pages
87-92issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(92)90745-Ujournal_volume
579pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived inna...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.033
更新日期：2009-10-06 00:00:00
abstract：:In a previous companion paper [Brain Res. 846 (1999) 87-105] we have shown that the dorsal root activity of a decerebrate cat is composed of both orthodromic and antidromic discharges as determined by spike triggered averaging (STA). Furthermore we have shown that, during fictive locomotion in decerebrate and paralyze...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.067
更新日期：2004-01-23 00:00:00
abstract：:There is much debate on the role of the superior colliculus (SC) in turning behaviour. In order to clarify this issue, unilateral kainate lesions were made by infusing 0.25 microgram of kainate at two different anterior planes (0.8 mm apart), in the lateral or in the medial aspects of the deep collicular layers (DLSC)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90557-1
更新日期：1982-04-08 00:00:00
abstract：:The effects of an intensive short-term glucocorticoid (e.g. triamcinolone) regimen in cats have been studied on the actions of the dopamine (DA) receptor agonist apomorphine (APO) on spinal lumbar primary afferent excitability (dorsal root reflex or DRR) and monosynaptic reflex (MSR) transmission. Glucocorticoid dosin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90894-6
更新日期：1983-05-16 00:00:00
abstract：:The glutamate terminals in rat rostral neostriatum were removed on one side by ipsilateral frontal cortical ablation. Intraperitoneal administration of L-methioninesulfoximine (MSO), an inhibitor of glutamine synthetase, induced different changes in amino acid concentration in the rostral neostriatum on the intact and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90261-6
更新日期：1985-07-08 00:00:00
abstract：:The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90594-y
更新日期：1992-01-20 00:00:00
abstract：:Repeated intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and angiotensin III (AIII) induced dipsogenic tachyphylaxis in the Sprague-Dawley rat. AIII caused a rapid suppression of drinking, whereas AII showed a progressive decline of water consumption with repeated injections. Tachyphylaxis due ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90010-8
更新日期：1988-06-14 00:00:00
abstract：:A comparison was made of the effects of left and right cerebral decortication on cytotoxic activity of natural killer and natural cytotoxic lymphocytes in the mouse. Natural killer cytotoxic activity was significantly reduced after right decortication, whereas left decortication led to a less pronounced, though still ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90704-f
更新日期：1990-08-06 00:00:00
abstract：:Enkephalin-like immunoreactive nerve fibers in the celiac ganglion of guinea pigs were characterized by a high population of large granular vesicles mixed with small clear vesicles. The immunoreactive material is confined to the large granular vesicles. The immunoreactive nerve fibers formed many axo-dendritic as well...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90987-8
更新日期：1982-12-02 00:00:00
abstract：:Biocytin, a naturally occurring low molecular weight analog of biotin, was evaluated as a neuroanatomical tract-tracing marker in the adult rat brain. Since it retains high-affinity binding to avidin, biocytin can be labelled with avidinylated visualization reagents. Iontophoretic or pressure injections resulted in fi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90281-3
更新日期：1989-09-18 00:00:00
abstract：:We examined the brain uptake of prostaglandin D2 after its i.v. administration to mice. The determination of this prostaglandin in tissues was performed by a sensitive and rapid radioimmunoassay after purification of the prostaglandin by high-performance liquid chromatography. When 1.0 mg/kg of prostaglandin D2 was in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91079-6
更新日期：1986-10-22 00:00:00
abstract：:NO performs a wide array of cell signaling functions. Neuronal NO synthase (nNOS) immunoreactivity and nicotinamide adenine dinucleotide phosphate diaphorase (NDP) activity, a marker of nNOS, were concentrated at adult rat neuromuscular junctions and persisted in denervated muscle indicating the localization of the en...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00675-0
更新日期：1996-08-19 00:00:00
abstract：:The possible involvement of catecholamines in the regulation of serotonin N-acetyltransferase (NAT) activity in retina of the African clawed frog was investigated using an in vitro eye cup preparation. Dopamine (10 microM) and norepinephrine (50 microM) had no significant effect on NAT activity of eye cups incubated i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90525-1
更新日期：1986-03-26 00:00:00
abstract：:Electrophysiological recordings in rat brain slices have been used to study the actions of adenosine on striatal neurons and striatal excitatory amino acid neurotransmission originating in the cortex or the thalamus. Adenosine had no effects on membrane properties of striatal neurons. Adenosine and the A1 agonist N6-C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01060-3
更新日期：1997-12-05 00:00:00
abstract：:To better understand the contributions of effort on cortical activation associated with motor tasks, healthy participants with varying capacities for isolating the control of individual finger movements performed tasks consisting of a single concurrent abduction of all digits (Easy) and paired finger abduction with di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.005
更新日期：2009-12-08 00:00:00
abstract：:The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90300-4
更新日期：1989-10-23 00:00:00
abstract：:Electrical self-stimulation in the lateral hypothalamus was recorded in both hemispheres of 20 rats before and after making a lesion either by unilateral radiofrequency stimulation or by injection of N-methyl-D,L-aspartate into the region of the peduncular-pontine nucleus. For the animals which received the radiofrequ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90836-6
更新日期：1989-05-22 00:00:00
abstract：:Recently generated knockout mice with disrupted genes encoding endothelin (ET)-1 showed an elevation of arterial blood pressure (AP) and supplied an evidence for intrinsic ET-1 as one of the physiological regulators of systemic AP. Little is yet known, however, why deficiency of ET-1, which was originally found as a p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00848-8
更新日期：1998-10-19 00:00:00
abstract：:A substantial projection from the retina to the dorsal raphe nucleus (DRN) has been demonstrated in the Chilean degus, a diurnal/crepuscular hystricomorph rodent. Following intraocular injection of cholera toxin subunit B (CTB), immunocytochemically labeled CTB-positive axons and terminals were observed in all major r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02061-3
更新日期：2001-03-23 00:00:00
abstract：:Six experimental and 3 unoperated cats were trained with a go, no-go shock avoidance procedure to discriminate increases from decreases in the rate of presentation of all auditory cortex between the suprasylvian sulcus and rhinal fissure while 3 cats had bilateral auditory cortex lesions plus ablation of the cortex of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90249-3
更新日期：1976-10-29 00:00:00
abstract：:The mismatch negativity, an ERP that reflects the detection of change in the auditory environment, is considered to be a relatively automatic process. Its automaticity has by in large been studied using the oddball paradigm, in which a physical feature of a frequently presented standard stimulus is changed. In the pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.07.031
更新日期：2008-10-09 00:00:00
abstract：:Close to 20% of the patients infected with the AIDS virus develops neurological deficit; eventhough HIV does not invade neurons. Consistently with the neurological deficit, HIV(+) subjects show abnormalities in brainstem auditory and visual evoked potentials (BSAEP and VEP) and in sleep patterns. The HIV-derived glyco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01572-3
更新日期：1999-07-31 00:00:00
abstract：:The distribution of melanin-concentrating hormone-like immunoreactivity (MCH-LI) in 41 microdissected brain and spinal cord regions was determined using radioimmunoassay with antibodies to salmon MCH. The highest concentration of MCH-LI was detected just ventral to the zona incerta (subzona incerta) (2923.2 fmol/mg pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90337-9
更新日期：1986-05-14 00:00:00
abstract：:Somatostatin-like immunoreactivity (Som-LI) and glycine high-affinity uptake have been characterized in the Rana pipiens retina. These labels are found in both the outer and inner plexiform layers (OPL and IPL), suggesting that interplexiform cells (IPCs) contain both Som and glycine in this retina. In double-label ex...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91215-8
更新日期：1989-08-21 00:00:00
abstract：:Neurotensin is a putative peptide neurotransmitter in the mammalian brain. The light microscopic localization of the neurotensin receptor has been carried out by the autoradiographic localization of [3H]neurotensin binding sites in slide-mounted tissue sections. Large variations in receptor distribution were found, ev...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90532-1
更新日期：1981-02-16 00:00:00
abstract：:The neuropathological consequences of acute exposure to the neurotoxicants ammonia and octanoic acid were investigated with the isolated, perfused canine brain preparation. After 1 h of combined hyperammonemia and octanoic acidemia, ultrastructural changes were apparent in all brain regions examined. The cell bodies o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90916-3
更新日期：1985-08-12 00:00:00
abstract：:Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02797-5
更新日期：2003-07-04 00:00:00
abstract：:Acetylcholinesterase (AchE) is an important peripheral membrane-bound enzyme, crucial for cholinergic neurotransmission. Changes in AchE activity, kinetic and thermotropic properties were studied in hepatic encephalopathy (HE) associated with acute liver failure induced experimentally by the administration of the hepa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.095
更新日期：2007-06-11 00:00:00
abstract：:This study tested the effect on intracranially injected cycloheximide (CHX), an inhibitor of protein synthesis, on facilitation of sexual receptivity in ovariectomized rats. The rats received 0.5 microgram estradiol benzoate (EB), s.c. once daily on days 8 through 12 after ovariectomy (OVX). Either CHX (in 0.5 microli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91050-7
更新日期：1981-10-19 00:00:00
abstract：:Mesencephalic dopamine neurons form synapses with acetylcholine (ACh)-containing interneurons in the nucleus accumbens (NAcc). Although their involvement in drug reward has not been systematically investigated, these large aspiny interneurons may serve an important integrative function. We previously found that repeat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.029
更新日期：2006-12-06 00:00:00
