Abstract:
:In a previous companion paper [Brain Res. 846 (1999) 87-105] we have shown that the dorsal root activity of a decerebrate cat is composed of both orthodromic and antidromic discharges as determined by spike triggered averaging (STA). Furthermore we have shown that, during fictive locomotion in decerebrate and paralyzed cats, antidromic discharges peak in different parts of locomotion cycle but mainly in the flexion phase. In the present study, we have recorded unit potentials from dorsal rootlets during treadmill locomotion in order to understand better the role of movement-related feedback in the generation of antidromic potentials. The unitary activity of 92 antidromically discharging units was recorded in proximal stumps of cut dorsal roots, and that of 20 such units was recorded in uncut roots using two bipolar Ag/AgCl electrodes in both cases. The activity of 80% (74/92) units in cut filaments and of 70% (14/20) units in uncut ones was phasewise related to stepping movements. The peaks of activity of different units occurred during different phases of the step cycle both in cut and uncut filaments. In most cases, the peak of activity was superimposed upon a background of sustained discharge. After blocking the orthodromic flow in a filament (local anesthesia or distal section), the antidromic discharges continued to peak during the same phase but the rate of the discharges increased. We conclude that movement-related afferent feedback significantly modulates the antidromic discharges in dorsal roots during treadmill locomotion. We suggest that these antidromic discharges have a role in controlling afferent feedback during movement.
journal_name
Brain Resjournal_title
Brain researchauthors
Beloozerova IN,Rossignol Sdoi
10.1016/j.brainres.2003.08.067subject
Has Abstractpub_date
2004-01-23 00:00:00pages
227-36issue
2eissn
0006-8993issn
1872-6240pii
S0006899303039490journal_volume
996pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The dorsal column and its nuclei exhibit a considerable number of fibers containing neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP), whose origins and functional roles are as yet unknown. The present study attempts to determine the origin and nature of these fibers by means of immuno...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91225-0
更新日期:1989-08-21 00:00:00
abstract::Transient foci of epileptiform alteration in neuronal population activity were induced by microinjection of strychnine sulfate into different layers of cat striate cortex. Potentials evoked by visual field-specific photic stimulation were recorded from microelectrodes at the injection site and in adjacent laminae. Epi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90938-2
更新日期:1985-08-12 00:00:00
abstract::Dual-labeling immunohistochemical or in situ hybridization studies for the recently cloned epsilon-subunit and several neuropeptides were performed in the rat hypothalamus. We revealed an extensive co-expression (>90%) with hypocretin (Hcrt), oxytocin (OT), the gonadotropin-releasing hormone (GnRH), and the melanin-co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04270-1
更新日期:2003-03-28 00:00:00
abstract::Maternal cocaine abuse has several deleterious effects in the newborn, including perinatal asphyxia, hypoxia, and hypercapnia. We hypothesized that chronic cocaine exposure during development may alter cerebral blood flow (CBF) regulation. We studied 16 neonatal rabbits that had received cocaine (20 mg/kg, i.p. b.i.d....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00178-9
更新日期:1997-04-25 00:00:00
abstract::In the brain, the neuropeptide cholecystokinin (CCK) appears to be involved in the mediation of stress responses. Here we provide new evidence that mild stress induces long-term changes in CCK-like immunoreactivity (CCK-LI) in the prefrontal cortex (PFC). The changes in CCK-LI show a biphasic pattern, with a decrease ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02648-8
更新日期:2001-07-27 00:00:00
abstract::In urethane-anesthetized rats, high frequency stimulation was applied to the medial perforant pathway at various time intervals (50, 100, 200, 350 and 500 ms) following stimulation of the same pathway by a single pulse of equal intensity. Recordings of dentate gyrus granule cell evoked responses were made to investiga...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91358-3
更新日期:1988-01-12 00:00:00
abstract::The connectivity of the stellate ganglion of Octopus was investigated using cobalt and horseradish peroxidase (HRP) tracers applied to severed preganglionic and postganglionic nerves. Centripetal cells, defined as cells in the ganglion which send their axons back toward the brain, were discovered by both methods. Appl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90583-1
更新日期:1980-02-17 00:00:00
abstract::The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90594-y
更新日期:1992-01-20 00:00:00
abstract::Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90941-2
更新日期:1985-12-09 00:00:00
abstract::Infection of neonatal mice with ts1, the neuropathogenic mutant of the Moloney murine leukemia virus, results in motor neuronal death in the brainstem and the spinal cord, with gliosis and demyelination, but no inflammatory cell infiltration into the CNS. To evaluate the possible mechanism(s) of ts1-induced neuropatho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00929-3
更新日期:1998-01-01 00:00:00
abstract::Aging represents a major risk factor for numerous illnesses that are of increasing importance to society, including two of the most prevalent: diabetes and Alzheimer's disease. Studies have shown that diabetes is a risk factor for spontaneous Alzheimer's disease. While these studies suggest that diabetes can contribut...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.04.026
更新日期:2015-07-30 00:00:00
abstract::Hyperactivity of the dopaminergic pathway is thought to contribute to clinical symptoms in the early stages of Huntington's disease (HD). It is suggested to be result of a reduced dopaminergic inhibition by degeneration of medium spiny neurons in the striatum. Previously, we have shown that the number of dopaminergic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.01.041
更新日期:2019-06-01 00:00:00
abstract::One model useful for demonstrating axonal regeneration in the central nervous system is that in which peripheral tissue, particularly the iris, is implanted into the brain or spinal cord. The aim of the present study was to establish the origin of some of the regenerating fibers by the use of an autoradiograhic tracin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91121-x
更新日期:1980-09-22 00:00:00
abstract::This manuscript describes the use of staining of Fos-related antigens (FRAs) as markers for changes in neuronal activity. The model system consisted of the tuberoinfundibular dopamine (TIDA) neurons located in the arcuate nucleus of the hypothalamus. Under normal conditions, these neurons are devoid of c-Fos staining ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90481-2
更新日期:1994-08-22 00:00:00
abstract:OBJECTIVE:Previously, we found that the inhaled anesthetic isoflurane up-regulated the transcriptional factor hypoxia inducible factor (HIF)-1α protein levels during induction of neurodegeneration in the brain of neonatal rats. Here, we investigated the role of HIF-1α and the underlying signaling pathway in the neurode...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.10.014
更新日期:2016-12-15 00:00:00
abstract::Effects of alpha-adrenoceptor agents on electrophysiologically and immunohistochemically identified supraoptic nucleus (SON) vasopressin (VP) units were investigated by intracarotid infusion. Clonidine, an alpha 2-adrenoceptor agonist always excited SON units and alpha 2-adrenoceptor antagonists consistently inhibited...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91526-x
更新日期:1986-12-10 00:00:00
abstract::Mammalian transglutaminases (TGs) catalyze the irreversible post-translational modifications of proteins, the most prominent of which is the calcium-dependent formation of covalent acyl transfers between the γ-carboxamide group of glutamine and the ε-amino-group of lysine (GGEL-linkage). In the central nervous system,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.11.027
更新日期:2016-01-15 00:00:00
abstract::Post-traumatic invasion of macrophages into the cochlear nerve of the rat and measurement of how their invasion was modified by the administration of methylprednisolone were investigated for the first time by using a reproducible and quantifiable experimental model of cochlear nerve injury. Two weeks after precise coc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02523-9
更新日期:2001-06-29 00:00:00
abstract::Previous work has shown a relatively high turnover of adrenaline in the mediobasal hypothalamus during the critical period (15.00-17.00 h) of the proestrous rat. We now report that this high level of adrenergic activity can be detected in the median eminence (turnover rate 1.62 +/- 0.36 pg/micrograms protein/h) rather...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90307-x
更新日期:1984-12-10 00:00:00
abstract::Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.014
更新日期:2009-08-11 00:00:00
abstract::This study was designed to evaluate the functional significance of angiotensin II (Ang II) receptors identified by previous receptor autoradiography studies to be located presynaptically on terminals of dopaminergic neurones projecting to the striatum. Microdialysis was performed in the striatum of conscious freely mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90902-y
更新日期:1993-06-11 00:00:00
abstract::Binding activities specific for each of [3H]prostaglandin (PG) D2, E2 and F2 alpha were detected in the P2 fraction of the human brain homogenates. The bindings were time-dependent, saturable and of high affinity; Kd values were 30 nM for all the PG bindings. Regional distribution of these binding activities was deter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91358-7
更新日期:1985-09-02 00:00:00
abstract::Galectin-3 (Gal-3) is a member of a class of carbohydrate-binding proteins and plays a role in a number of cellular functions such as cell proliferation, angiogenesis and differentiation. We observed an up-regulated expression of Gal-3 in the ischemic brain following transient middle cerebral artery occlusion in rats....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.073
更新日期:2009-09-08 00:00:00
abstract::The presence of adrenocorticotropic hormone (ACTH)-immunoreactive cells and melanocortin (MC) receptors (MC4 and to a lesser extent MC3) has been demonstrated in the medullary reticular formation in the general area where rostral ventrolateral medullary pressor area (RVLM) is located. The importance of RVLM in the reg...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.002
更新日期:2006-08-02 00:00:00
abstract::The role of gangliosides in preventing neuronal degeneration was examined in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse parkinsonian model. Intraventricular injections of a ganglioside mixture prior to MPTP treatment reduced MPTP's toxicity on tyrosine hydroxylase-positive neurons in the subst...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91154-9
更新日期:1990-09-17 00:00:00
abstract::Axon-to-myelin transfer of lipids precursors have been studied in the rabbit optic system by intraocular injection of [32P]orthophosphate, [14C]glycerol and [3H]glycerol. Choline and ethanolamine phosphoglycerides and myelin showed increasing [32P]-radioactivity between 7 and 21 days following injection, while [3H]- a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90136-1
更新日期:1983-06-20 00:00:00
abstract::Recently, a novel method for detection of DNA synthesis has been developed based on the incorporation of 5-ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction). In the present stud...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.12.092
更新日期:2010-03-10 00:00:00
abstract::Selective D1 (SCH-23390) and D2 (eticlopride and sulpiride) dopamine receptor antagonists were assessed for their ability to reverse the effects of 1.0 mg/kg D-amphetamine on excitatory motor-related neurons in the striatum of freely moving rats. SCH-23390 (0.125, 0.25, 0.5 and 1.0 mg/kg) rapidly and consistently bloc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91633-4
更新日期:1993-08-13 00:00:00
abstract::The presence of an adrenergic projection from the nucleus of the tractus solitarius (NTS) to the parabrachial nucleus (PB) was demonstrated by the immunocytochemistry combined with a retrograde tracing method. Numerous neurons containing both phenylethanolamine N-methyltransferase, a marker for adrenaline, and wheat g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90654-3
更新日期:1988-09-06 00:00:00
abstract::Aging is accompanied by a general deterioration of fluid cognitive processes and a reduction in resting cerebral blood flow (CBF). While the two phenomena have been observed independently, it is uncertain whether individual differences in cerebral blood flow are reliably associated with cognitive functioning in older ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.12.020
更新日期:2010-02-22 00:00:00