Abstract:
:Dual-labeling immunohistochemical or in situ hybridization studies for the recently cloned epsilon-subunit and several neuropeptides were performed in the rat hypothalamus. We revealed an extensive co-expression (>90%) with hypocretin (Hcrt), oxytocin (OT), the gonadotropin-releasing hormone (GnRH), and the melanin-concentrating hormone (MCH) peptides, whereas occasional co-expression (<10%) with cocaine-amphetamine-regulated transcript (CART) was found. Our results suggest that novel GABA(A) receptor subtypes comprising epsilon-subunit are important for metabolic and neuroendocrine functions.
journal_name
Brain Resjournal_title
Brain researchauthors
Moragues N,Ciofi P,Lafon P,Tramu G,Garret Mdoi
10.1016/s0006-8993(02)04270-1subject
Has Abstractpub_date
2003-03-28 00:00:00pages
285-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302042701journal_volume
967pub_type
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