GABAA receptor epsilon subunit expression in identified peptidergic neurons of the rat hypothalamus.

Abstract:

:Dual-labeling immunohistochemical or in situ hybridization studies for the recently cloned epsilon-subunit and several neuropeptides were performed in the rat hypothalamus. We revealed an extensive co-expression (>90%) with hypocretin (Hcrt), oxytocin (OT), the gonadotropin-releasing hormone (GnRH), and the melanin-concentrating hormone (MCH) peptides, whereas occasional co-expression (<10%) with cocaine-amphetamine-regulated transcript (CART) was found. Our results suggest that novel GABA(A) receptor subtypes comprising epsilon-subunit are important for metabolic and neuroendocrine functions.

journal_name

Brain Res

journal_title

Brain research

authors

Moragues N,Ciofi P,Lafon P,Tramu G,Garret M

doi

10.1016/s0006-8993(02)04270-1

subject

Has Abstract

pub_date

2003-03-28 00:00:00

pages

285-9

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006899302042701

journal_volume

967

pub_type

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