Abstract:
:This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18-30 years old) and 43 seniors (60-75 years old) were included. A general executive score was derived from a large battery of neuropsychological tests assessing three major aspects of executive functioning (inhibition, updating and shifting). Age-related grey matter changes were investigated by comparing young and older adults using voxel-based morphometry and voxel-based cortical thickness methods. A widespread difference in grey matter volume was found across many brain regions, whereas cortical thinning was mainly restricted to central areas. Multivariate analyses showed age-related changes in relatively similar brain regions to the respective univariate analyses but appeared more limited. Finally, in the older adult sample, a significant relationship between global executive performance and decreased grey matter volume in anterior (i.e. frontal, insular and cingulate cortex) but also some posterior brain areas (i.e. temporal and parietal cortices) as well as subcortical structures was observed. Results of this study highlight the distribution of age-related effects on grey matter volume and show that cortical atrophy does not appear primarily in "frontal" brain regions. From a cognitive viewpoint, age-related executive functioning seems to be related to grey matter volume but not to cortical thickness. Therefore, our results also highlight the influence of methodological aspects (from preprocessing to statistical analysis) on the pattern of results, which could explain the lack of consensus in literature.
journal_name
Brain Resjournal_title
Brain researchauthors
Manard M,Bahri MA,Salmon E,Collette Fdoi
10.1016/j.brainres.2016.04.045subject
Has Abstractpub_date
2016-07-01 00:00:00pages
562-580eissn
0006-8993issn
1872-6240pii
S0006-8993(16)30265-7journal_volume
1642pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Angiotensin converting enzyme (ACE) is Zn2+ metallopeptidase which plays an important role in blood pressure homeostasis in mammals and other vertebrates. Homologues of ACE involved in the biosynthesis of mammalian peptide hormones have also been identified in the insects, Musca domestica, Drosophila melanogaster and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01398-x
更新日期:1998-03-02 00:00:00
abstract::Metabolic stress imposed by epileptic seizures can result in mitochondrial dysfunction, believed to act as positive feedback on epileptogenesis and seizure susceptibility. As the mechanism behind this positive feedback is unclear, the aim of the present study was to investigate the causal link between acute mitochondr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147193
更新日期:2021-01-15 00:00:00
abstract::Perinatal exposure to cannabinoids has been shown to elicit central nervous system impairment in rodents. This includes changes in monoaminergic and neuropeptidergic activities. We have examined the effect of perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) on sensitivity to radiant heat in both male a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00255-o
更新日期:1995-05-22 00:00:00
abstract::The objective of this study was to assess the influence of Ca2+ influx on intracellular pH (pHi) of neocortical neurons in primary culture. Neurons were exposed to glutamate (100-500 microM) or KCl (50 mM), and pHi was recorded with microspectrofluorometric techniques. Additional experiments were carried out in which ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00056-v
更新日期:1995-04-10 00:00:00
abstract::Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91265-2
更新日期:1980-01-06 00:00:00
abstract::Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amn...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90807-9
更新日期:1987-03-17 00:00:00
abstract::In the present study, the role of medial septal receptors in behaviour-induced increase in acetylcholine (ACh) release in hippocampus was investigated using dual-probe microdialysis in combination with a simple behavioural procedure. gamma-Aminobutyric acid (GABA) and glutamate receptor agonists and antagonists were a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01445-5
更新日期:1998-04-06 00:00:00
abstract::These experiments used in vivo microdialysis and high-performance liquid chromatography to examine, in rats, norepinephrine (NE) release in the amygdala induced by footshock and systemic administration of drugs affecting the opioid peptidergic system. A microdialysis probe was inserted into a previously implanted guid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00795-1
更新日期:1998-10-19 00:00:00
abstract::The effects of naltrexone, naltrindole (a selective delta opiate receptor antagonist) and beta-funaltrexamine (beta-FNA; a selective mu opiate receptor antagonist) on alcohol intake by C57BL/6 mice in a restricted access paradigm were examined. During the pretreatment baseline phase, mice consumed an average of 1.3 g/...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90672-a
更新日期:1993-12-10 00:00:00
abstract::Hamsters exhibited a circadian variation in metabolic activity determined by [14C]2-deoxyglucose uptake in the suprachiasmatic nuclei, as has been previously reported for rats. The 13-line ground squirrel, a diurnal rodent, did not show a circadian variation in metabolic activity. The data are consistent with the hypo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90626-6
更新日期:1982-01-28 00:00:00
abstract::In pentobarbitone-anesthetized cats breathing spontaneously, we studied whether excision of one petrosal ganglion would modify the reflex efficacy of the remaining carotid and aortic chemoafferences in ventilatory control. Resting ventilation was not affected shortly after the ganglionectomy, but decreased sensitiviti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91495-3
更新日期:1990-07-23 00:00:00
abstract::Alteration of blood-brain barrier (BBB) permeability by 2450 MHz CW microwaves was assessed semi-quantitatively after intravenous injection of horseradish peroxidase (HRP) and exposure of conscious, unrestrained rats to incident power densities of 0, 20 or 65 mW/cm2 for 30, 90 or 180 min. Additional rats were exposed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-0173(84)90022-5
更新日期:1984-05-01 00:00:00
abstract::Some kinds of nociception appear to be partially mediated by the release of substance P (SP) in the spinal cord dorsal horn from terminals of primary afferent nociceptors. Only some nociceptors contain and release SP however. Specifically, SP appears to be released by unmyelinated (C) nociceptive afferents when activa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01466-7
更新日期:1997-03-28 00:00:00
abstract::Frequency-current curves for CA1 hippocampal pyramidal neurons are shown to have basically the same shape as those for spinal motoneurones, with a region of shallow slope at low frequencies, preceding a sleep linear or upward convex region at higher frequencies. The frequency range is, however, displaced towards lower...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91158-6
更新日期:1981-11-02 00:00:00
abstract::The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent mann...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91331-a
更新日期:1990-08-13 00:00:00
abstract::Phosphocreatine-Mg-complex acetate (PCr-Mg-CPLX) is a creatine-derived compound that in previous in vitro research was able to increase neuronal creatine independently of the creatine transporter, thus providing hope to cure the hereditary syndrome of creatine transporter deficiency. In previous research we showed tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.009
更新日期:2009-08-18 00:00:00
abstract::Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90515-5
更新日期:1989-05-08 00:00:00
abstract::Endogenous opioid systems (i.e. opioids and opioid receptors) play a role in regulating neural development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides involved with cell proliferation were assessed. In both the external germinal (granule) layer (EGL), a germinative matrix giving ris...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91585-o
更新日期:1991-03-01 00:00:00
abstract::In an effort to further characterize the proteins of the auditory nerve, the effects of hair cell loss on rapidly transported proteins of the auditory nerve were studied. The effects were studied in the waltzing guinea pig, a genetically deaf animal which displays an age-dependent loss of sensory cells, and in normal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90693-x
更新日期:1982-12-16 00:00:00
abstract::During early postnatal development in reeler mutant mice, lectin binding delineates prospective abnormal barrels as they will appear in the adult mutant somatosensory cortex. Glial fibers also may be more condensed within fascicles in developing reeler barrels. These fibers also appear to be misaligned, coursing predo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90112-x
更新日期:1987-04-01 00:00:00
abstract::Recently, much attention has focused on the role of the melanocortin system in the regulation of energy homeostasis, especially the satiety effects of the pro-opiomelanocortin (POMC)-derived peptide alpha-melanocyte stimulating hormone (alpha-MSH). We have found that POMC mRNA levels are similar in fat and thin sheep ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02918-3
更新日期:2001-11-09 00:00:00
abstract::The parabrachial nucleus consists of several subnuclei which contains autonomic, gustatory, visceral sensory, nociceptive, and respiratory related neurons. We have investigated the direct projections from the rat parabrachial region, including the K olliker-Fuse nucleus, to the pharyngeal motoneurons with an anterogra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01127-5
更新日期:1999-01-23 00:00:00
abstract::This study describes the localization of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics, in the hypothalamus of Swiss Webster and C57BL/6J wild-type mice, leptin-deficient ob/ob mice, and leptin-resistant diet-induced obese (DIO) mice. The mice were given [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in 0.3...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.03.020
更新日期:2017-06-01 00:00:00
abstract::We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As prev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91085-1
更新日期:1986-10-22 00:00:00
abstract::A 'new' and orderly representation of the body surface was found in the cerebral cortex of the cat. This somatotopic map was located in the anterior ectosylvian sulcus (AES), an area known to represent several modalities, but believed to be distinguished from primary sensory cortex by its lack of sensory topographies....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90207-4
更新日期:1982-03-04 00:00:00
abstract::We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91442-2
更新日期:1984-04-30 00:00:00
abstract::The Snell dwarf mouse (dw/dw) shows significantly decreased somatostatin levels in the hypothalamus whereas more or less increased somatostatin concentrations are observed in any central extrahypothalamic sites studied. These opposite results in hypothalamus and extrahypothalamic areas may be linked to the apparently ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91337-x
更新日期:1985-02-25 00:00:00
abstract::To see if activation of central alpha 1-adrenergic receptors can cause facilitation of lordosis in rats, the behavioral effects of centrally administered alpha 1-agonists, methoxamine (MA) and phenylephrine (PhE), and related agents were studied. In ovariectomized rats treated with estrogen, infusion of MA, PhE, or a ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91581-x
更新日期:1992-08-21 00:00:00
abstract::The present report summarizes the results obtained in previous experiments in which the responses to lateral tilt of both reticulocerebellar neurons located in the lateral reticular nucleus (NRL) and ascending spinoreticular tract axons, located in the lateral funiculi of the cervical segments C2-C3, had been recorded...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90112-2
更新日期:1975-09-23 00:00:00
abstract::A cluster of trigeminal nociceptive neurons was located in the lateral sulcus on the upper bank of the frontoparietal operculum in a region bordering between cortical areas SII and 7b. These neurons were isolated in cortical cell layers IV and V-VI. All nociceptive neurons responded exclusively to noxious mechanical s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90375-2
更新日期:1989-04-10 00:00:00