Central modulation of gastric pressure by substance P: a comparison with glutamate and acetylcholine.

Abstract:

:We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As previously reported, L-glu and ACh, but not SP elicited dose-dependent arterial hypotension. The data support a putative role for SP in visceral reflexes mediated by vagal nerves.

journal_name

Brain Res

journal_title

Brain research

authors

Spencer SE,Talman WT

doi

10.1016/0006-8993(86)91085-1

subject

Has Abstract

pub_date

1986-10-22 00:00:00

pages

371-4

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(86)91085-1

journal_volume

385

pub_type

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