Abstract：
:This study was performed to understand the anatomical substrates of hypothalamic modulation of jaw movements. After cholera toxin B subunit (CTb) injection into the parvicellular reticular formation (RFp) of the rat medulla oblongata, where many trigeminal premotor neurons have been known to exist, numerous CTb-labeled neurons were found in the posterior lateral hypothalamus (PLH) bilaterally with a clear-cut ipsilateral dominance. After ipsilateral injections of biotinylated dextran amine (BDA) into the PLH and CTb into the motor trigeminal nucleus (Vm), the prominent distribution of BDA-labeled axon terminals around CTb-labeled neurons was found in the RFp region just ventral to the nucleus of the solitary tract and medial to the spinal trigeminal nucleus ipsilateral to the injection sites. Within the neuropil of the RFp, BDA-labeled axon terminals made an asymmetrical synaptic contact predominantly with dendrites and additionally with somata of the RFp neurons, some of which were labeled with CTb. It was further revealed that these BDA-labeled axon terminals were immunoreactive for vesicular glutamate transporter 2. The present data suggest that the PLH plays an important role in the control of jaw movements by exerting its glutamatergic excitatory action upon RFp neurons presynaptic to trigeminal motoneurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Notsu K,Tsumori T,Yokota S,Sekine J,Yasui Ydoi
10.1016/j.brainres.2008.09.076subject
Has Abstractpub_date
2008-12-09 00:00:00pages
71-81eissn
0006-8993issn
1872-6240pii
S0006-8993(08)02367-6journal_volume
1244pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:We examined the contribution of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxalole-4-propionic acid (AMPA)/kainate (KA) receptors to the light-responses of rabbit retinal neurons. In the outer retina, bath application of the AMPA/KA receptor antagonists 6,7-dinitro-quinoxaline-2,3-dione (DNQX) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01448-1
更新日期：1999-06-12 00:00:00
abstract：:Enkephalin immunoreactive neurons within the nucleus tractus solitarius (NTS) were found to project to the parabrachial nucleus of the cat with the use of a combination of immunohistochemistry and retrograde transport of horseradish peroxidase. Double labelled neurons were located in the medial, parvocellular and comm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91521-1
更新日期：1988-03-01 00:00:00
abstract：:The aim of this study was to identify the medullary vagal nuclei involved in the different phases of swallowing activated physiologically in a species with an esophagus similar to human. In decerebrate cats, the pharyngeal (0.5-1.0 ml water in pharynx (N=6)) or esophageal (1-3 ml air in esophagus (N=5)) phases of swal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.061
更新日期：2004-07-16 00:00:00
abstract：:The effect of arginine vasopressin (AVP) on protein phosphorylation in rat hippocampal synaptic plasma membranes (SPM) was examined. With a crude SPM preparation, AVP (10(-8)-10(-5) M) stimulated phosphorylation of a number of proteins which included a brain-specific protein of 48 kDa called B50 or protein F1, which i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91231-x
更新日期：1986-10-01 00:00:00
abstract：:Seizure is a common acute and severe disease in infants and children. Recurrent seizures or persistent seizures may cause irreversible brain damage. Mitogen activated protein kinase (MAPK) signaling pathway is associated with an inflammatory response, however it's involvement in the pathological process of seizures is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146932
更新日期：2020-10-15 00:00:00
abstract：:Glucocorticoid receptor (Gr) concentrations in the rat brain are low at the time of birth and increase towards adult levels during the first two weeks of life. Brief, daily handling of pups for the first 21 days postnatally has been found to permanently increase Gr concentrations within the hippocampus. Thus, the deve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90183-x
更新日期：1985-10-01 00:00:00
abstract：:Total RNA was extracted from 15-day-old whole rat brains. Microinjection of the RNA into Xenopus laevis oocytes induced electrophysiological responsiveness to cholecystokinin-8 (CCK) and bombesin (BBS) but not to corticotropin-releasing factor (CRF) or somatostatin. The responses to CCK and BBS were similar in shape, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90021-6
更新日期：1988-08-01 00:00:00
abstract：:Leukocyte cell-derived chemotaxin 2 (LECT2) was first isolated as a chemotactic factor from phytohemagglutinin-activated human T-cell leukemia SKW-3 cells. LECT2 is expressed in various tissues, including in the brain, stomach and liver, but the functions of LECT2 in the brain remains unclear. To elucidate these funct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.010
更新日期：2010-01-22 00:00:00
abstract：:Anandamide (arachydonylethanolamide) is a naturally-occurring ligand of the canabinoid receptor. When anandamide binds to its receptor, adenylate cyclase is inhibited. At the frog neuromuscular junction, anandamide lessened the increase in quantal size produced by pretreatment in hypertonic solution. It did not alter ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91062-6
更新日期：1994-06-27 00:00:00
abstract：:Endothelins are potent vasoconstrictors and signaling molecules. Their effects are broad, impacting processes ranging from neurovascular and cardiovascular health to cell migration and survival. In stroke, traumatic brain injury or subarachnoid hemorrhage, endothelin-1 (ET-1) is induced resulting in cerebral vasospasm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.022
更新日期：2014-11-07 00:00:00
abstract：:There have been few reports concerning facilitation and depression in sympathetic ganglia9,17,40. In the present investigation, pairs of excitatory postsynaptic potentials (EPSPs) were recorded intracellularly from bullfrog paravertebral sympathetic ganglia for an analysis of the site and mechanism responsible for the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90840-4
更新日期：1976-12-10 00:00:00
abstract：:A double-label immunofluorescence technique was used to demonstrate that immunoreactivities for the functionally antagonistic neuropeptides enkephalin and cholecystokinin octapeptide (CCK) are co-localized within individual neurons and processes in discrete areas of rat midbrain and forebrain. Coexistence was most pro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90085-0
更新日期：1987-02-17 00:00:00
abstract：:An in vitro preparation of the medulla oblongata of the rat was used to examine the responses to reducing pH, at constant CO2, of neurons in several identified nuclei. Neurons in an area close to the ventral surface, which is thought to be the location of pH-sensitive central respiratory chemoreceptors, did not respon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90300-1
更新日期：1983-07-25 00:00:00
abstract：:We found a differential postnatal development of mu and delta opiate receptors. Mu receptors labelled with low concentrations of [3H]naloxone appeared to develop earlier than did delta receptors labelled with [3H]D-Ala2-D-Leu5-enkephalin (0.5 nM). Competition binding studies also revealed a delayed appearance of delta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90066-9
更新日期：1982-04-01 00:00:00
abstract：:Hypothalamic stimulation generally inhibits baroreflex-induced bradycardia. However, we have noted discrete areas of the rat hypothalamus which facilitate reflex bradycardia. The effects of hypothalamic stimulation on baroreflex-induced changes in heart rate were investigated in urethane-anesthetized rats (1.2 g/kg, i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91163-7
更新日期：1986-10-08 00:00:00
abstract：:Neurofibrillary tangles (NFT) are pathological cytoskeletal structures composed of paired helical filaments (PHF), and are found in neurons of patients afflicted with many neurodegenerative disorders, including Alzheimer's disease (AD). We previously found that an antiserum against casein kinase II (CK-II) stained NFT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90121-o
更新日期：1992-02-21 00:00:00
abstract：:Inhibition of Aβ production and clearance of senile plaques have been considered as potential strategies in the treatment of Alzheimer's disease (AD). Activated protein C (APC) is an important factor in the anticoagulant system. However, whether APC can influence the condition of a chronic neurodegenerative process, s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.12.005
更新日期：2014-01-30 00:00:00
abstract：:A significant fall in the number of GABA-immunoreactive cells in laminae I-III of the rat spinal cord occurred in the somatotopic area of projection of the sciatic nerve after nerve transection. The decrease started at 2 weeks post-neurectomy, and at 4 weeks ipsilateral mean cell numbers were approximately 72% of cont...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90167-l
更新日期：1993-08-27 00:00:00
abstract：:Breakdown products (BDPs) resulting from the partial proteolysis of spectrin were examined in hippocampal slices after periods of hypoxia lasting for 5 or 10 min. The concentration of a approximately 155 kDa BDP increased nearly twofold after 5 min of hypoxia; further increases were not seen with 10 min episodes or 10...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90352-v
更新日期：1991-08-02 00:00:00
abstract：:We report here that following partial spinal transections in adult lampreys, the fibers of the spinal cords can regenerate and restore some intersegmental coordination to the central pattern generator for locomotion, as tested in the isolated cord preparation. However, the regeneration by this test is not successful i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91090-1
更新日期：1989-09-04 00:00:00
abstract：:Ciliary ganglion neurons from chick embryo were grown in cell culture following enzymatic and mechanical dissociation. The culture conditions necessary for long-term (greater than 21 days) survival of the isolated neurons were investigated. Neurons could be cultured with and without non-neural cells by adjusting the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90127-4
更新日期：1980-02-03 00:00:00
abstract：:The mechanism of the antinociceptive effect of the tricyclic antidepressant imipramine was investigated in mice. Intrathecal (i.t.) administration of imipramine produced dose-dependent antinociception in the tail-pinch and tail-flick tests with ED50 values (95% confidence limit) of 27.5 (17.0-43.9) and 20.2 (12.6-32.2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90344-9
更新日期：1992-05-22 00:00:00
abstract：:Chronic developmental exposure to ethanol can lead to a wide variety of teratogenic effects, which in humans are known as fetal alcohol spectrum disorders (FASD). Individuals affected by FASD may exhibit persistent impairments to cognitive functions such as learning, memory, and attention, which are highly dependent o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.10.005
更新日期：2018-01-01 00:00:00
abstract：:The effects of retinoic acid (RA), a naturally occurring metabolite of vitamin A, on the growth, morphology and neurochemical differentiation of the PC12 clone of rat pheochromocytoma cells were investigated. RA added to the medium inhibited the growth of PC12 cells in a dose-dependent manner up to 10 microM without a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90460-5
更新日期：1989-11-13 00:00:00
abstract：:The subfornical organ of the brain has a role in the regulation of fluid balance in higher animals. In this study the effects of salt loading and water deprivation on specific proteins in this organ were investigated. For 4 days, 3 groups of rats were given an appropriate fluid diet (control, 2% NaCl and water deprive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91463-0
更新日期：1986-04-30 00:00:00
abstract：:Serotonin 1A (5HT1A) receptor agonists have shown neuroprotective properties in different models of central nervous system injury. Activation of neuronal 5HT1A receptors appears to be involved in the neuroprotective effects. It remains to be elucidated if astroglial cells are responsive to the 5HT1A neuroprotective ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.10.019
更新日期：2004-12-31 00:00:00
abstract：:The astrocyte-derived protein S100B stimulates production of inducible nitric oxide synthase and nitric oxide (NO) in astrocytes [Hu et al., 1996, J. Biol. Chem. 271:2543], but its effect on microglia is not known. In addition, S100B's ability to modulate the activity of other glial activating agents has not been defi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02251-9
更新日期：2000-01-17 00:00:00
abstract：:Previous studies have reported that high concentrations of homocysteine and lower concentrations of vitamins B6, B12, and folate increase the risk for cognitive decline and pathology in aging populations. In this cross-sectional study, high resolution magnetic resonance imaging (MRI) scans and a 3-day food diary were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.030
更新日期：2008-03-14 00:00:00
abstract：:The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01952-6
更新日期：1999-10-16 00:00:00
abstract：:The effects of spinal cord hemisection on protein labeling in the medulla, pons, midbrain, and cortex in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of brain. Animals were sacrificed 3, 6 or 13 days after hemisectio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90458-9
更新日期：1977-02-25 00:00:00
