Cholinergic differentiation of clonal rat pheochromocytoma cells (PC12) induced by retinoic acid: increase of choline acetyltransferase activity and decrease of tyrosine hydroxylase activity.

abstract：:K+ and Cl- transport using 42K+ and 36Cl- was studied in primary astrocyte cultures prepared from neonatal rat brains. A component of 42K+ uptake was sensitive to both furosemide and bumetanide with maximum inhibition being obtained at 1 and 0.01 mM concentrations of the inhibitors, respectively. Furosemide and bumeta...

journal_title：Brain research

authors： Kimelberg HK,Frangakis MV

更新日期：1985-12-30 00:00:00

abstract：:Although nitric oxide (NO) has been shown to play an important role in the pathophysiology of cerebral ischemia, its contribution to the pathogenesis of experimentally induced thromboembolic stroke is unknown. In this study, we pharmacologically manipulated NO levels in the acute post-thrombotic stage and determined t...

journal_title：Brain research

authors： Stagliano NE,Dietrich WD,Prado R,Green EJ,Busto R

更新日期：1997-06-06 00:00:00

abstract：:Diabetes mellitus (DM) may lead to gastrointestinal motility disorders. Rodent models of DM indicate the presence of morpho-functional abnormalities of the enteric nervous system. Here, we evaluated whether experimental DM can cause changes in the excitatory cholinergic fibers, neuronal density, and voltage-gated sodi...

journal_title：Brain research

authors： Brasileiro AD,Garcia LP,de Carvalho da Silva S,Rocha LB,Pedrosa AL,Vieira AS,da Silva VJD,Rodrigues ARA

更新日期：2019-04-01 00:00:00

abstract：:Pain resulting from peripheral nerve injury, characterised by ongoing pain, hyperalgesia and allodynia arises from peripheral and central processes. Here, we studied the potential role of central facilitations in nerve injury by investigating the effect of blocking the excitatory 5HT3 receptor with ondansetron. 5HT3 r...

journal_title：Brain research

authors： Suzuki R,Rahman W,Hunt SP,Dickenson AH

更新日期：2004-09-03 00:00:00

abstract：:Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced ...

journal_title：Brain research

authors： Wagner GC,Ricaurte GA,Seiden LS,Schuster CR,Miller RJ,Westley J

更新日期：1980-01-06 00:00:00

abstract：:The lateral geniculate nucleus (LGN) receives input from the retina that is spatially organized into a receptive-field center and surround. It maintains this organization in the signal that it sends to the visual cortex. Previous studies have focused on changes in the receptive-field 'surround' that are generated at t...

journal_title：Brain research

authors： Norton TT,Holdefer RN,Godwin DW

更新日期：1989-05-29 00:00:00

abstract：:Six experimental and 3 unoperated cats were trained with a go, no-go shock avoidance procedure to discriminate increases from decreases in the rate of presentation of all auditory cortex between the suprasylvian sulcus and rhinal fissure while 3 cats had bilateral auditory cortex lesions plus ablation of the cortex of...

journal_title：Brain research

authors： Cranford JL,Igarashi M,Stramler JH

更新日期：1976-10-29 00:00:00

abstract：:We have used magnetic resonance imaging (MRI) of the living rat brain to longitudinally analyze the ontogenesis of an ibotenic acid lesion targeted at the piriform cortex. The MRI data were systematically compared with data obtained from a battery of histopathological techniques, including Nissl stain, hematoxylin sta...

journal_title：Brain research

authors： Ben-Horin N,Hazvi S,Bendel P,Schul R

更新日期：1996-04-29 00:00:00

abstract：:Cerebral cortex membranes from rats habituated to manipulations preceding decapitation (habituated rats) had 40% higher GABA binding than membranes from naive animals. Diazepam (5 X 10(-6) M), added to membranes from naive rats, increased GABA binding to the level of habituated rats, but failed to induce any further i...

journal_title：Brain research

authors： Biggio G,Concas A,Serra M,Salis M,Corda MG,Nurchi V,Crisponi C,Gessa GL

更新日期：1984-07-02 00:00:00

abstract：:Active substance P binding sites were solubilized from rat brain membranes by treatment with 0.125% sodium glycodeoxycholate and 1 M NaCl. About 50% of the binding activity in membrane-bound binding sites was recovered in the solubilized fraction after centrifugation at 105,000 g for 1 h. [3H]Substance P absorbed exte...

journal_title：Brain research

authors： Maruyama M

更新日期：1986-04-02 00:00:00

abstract：:Electrophysiological recordings were made from afferent nerve fibres supplying slowly adapting type I (SA I) cutaneous mechano-receptors in the cat during application of mechanical stimuli (20 mN constant force, 0.2 s rise time and 2 s plateau phase, every 30 s). Close arterial infusion of neomycin (2.5 mg/min for 5 m...

journal_title：Brain research

authors： Baumann KI,Hamann W,Leung MS

更新日期：1986-07-02 00:00:00

abstract：:Subcommissural organ (SCO) is a highly specialized ependymal gland located in the roof of the third ventricle. The secretory products of the SCO, which condense to form Reissner's fiber (RF), were recently found to cross-react with the anti-calcitonin antibody. To understand the mechanisms regulating the formation of ...

journal_title：Brain research

authors： Saha SG,Jain MR,Subhedar N

更新日期：2000-01-10 00:00:00

abstract：:The distribution of melanin-concentrating hormone-like immunoreactivity (MCH-LI) in 41 microdissected brain and spinal cord regions was determined using radioimmunoassay with antibodies to salmon MCH. The highest concentration of MCH-LI was detected just ventral to the zona incerta (subzona incerta) (2923.2 fmol/mg pr...

journal_title：Brain research

authors： Zamir N,Skofitsch G,Jacobowitz DM

更新日期：1986-05-14 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH)-like immunoreactivity was examined in the rat olfactory bulb by an immunohistochemical method using antiserum against the tripeptide TRH. TRH-immunoreactive neurons and neuronal processes were localized in both main and accessory olfactory bulb, including the glomerular layer, exter...

journal_title：Brain research

authors： Tsuruo Y,Hökfelt T,Visser TJ

更新日期：1988-04-26 00:00:00

abstract：:In a previous study, male rats showed behavioural deficits after a single restraint stress but not after 5 daily restraint periods (i.e. adaptation had developed): female rats although less affected by single restraint failed to adapt over the same time course. This sex difference was associated with the male but not ...

journal_title：Brain research

authors： Haleem DJ,Kennett G,Curzon G

更新日期：1988-08-23 00:00:00

abstract：:At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater...

journal_title：Brain research

authors： Messersmith DJ,Fabrazzo M,Mocchetti I,Kromer LF

更新日期：1991-08-23 00:00:00

abstract：:The blockade of central histaminergic H(2) receptors has been reported to aggravate ischemic neuronal damage. Since excess release of excitatory neurotransmitters is closely related to ischemic neuronal damage, the effects of ranitidine on ischemic release of dopamine were investigated in gerbil striatum. Changes in t...

journal_title：Brain research

authors： Adachi N,Terao K,Otsuka R,Arai T

更新日期：2002-02-01 00:00:00

abstract：:The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...

journal_title：Brain research

authors： Jalonen T,Holopainen I

更新日期：1989-04-10 00:00:00

abstract：:The effect of an 8% casein and a control 25% casein diet on the granule cells in the dorsal blade of the dentate gyrus of the rat hippocampal formation was studied at 30, 90 and 220 days of age. Female rats were fed either an 8% or 25% casein diet 5 weeks prior to conception and the litters were maintained on these re...

journal_title：Brain research

authors： Cintra L,Díaz-Cintra S,Galván A,Kemper T,Morgane PJ

更新日期：1990-11-05 00:00:00

abstract：:This paper describes carbon fibre electrodes that can simultaneously monitor changes in ascorbic acid, dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in vivo in the rat striatum using differential pulse voltammetry. The separation between DOPAC and 5HIAA oxidation is...

journal_title：Brain research

authors： Crespi F,Sharp T,Maidment NT,Marsden CA

更新日期：1984-11-19 00:00:00

abstract：:To study the regulation of striatal acetylcholine (ACH) release, adult male rat striata were dissociated and incubated with 3H-choline to synthesize 3H-ACH. Fractional 3H-ACH efflux per min during continuous perifusion was: (1) tightly regulated; (2) dependent on calcium influx; (3) stimulated by 10 mM K+ and 1 mM glu...

journal_title：Brain research

authors： Login IS,Borland K,Harrison MB,Ragozzino ME,Gold PE

更新日期：1995-10-30 00:00:00

abstract：:The optic tecta of 55 Rutilus rutilus were examined at intervals varying from 2 days to 4 years after unilateral retinal ablation. Qualitative ultrastructural examination of the retinal target lamina of the optic tectum (stratum fibrosum et griseum superficiale, SFGS) revealed that an initial period of degeneration an...

journal_title：Brain research

authors： Peyrichoux J,Pierre J,Repérant J,Rio JP,Ward R

更新日期：1988-05-03 00:00:00

abstract：:Spreading depression (SD) is a wave of cellular depolarization which contributes to neuronal damage in experimental focal ischaemia, and may also underlie the migraine aura. The purpose of this study was to examine the effects of probenecid, an inhibitor of organic anion transport, on K+-evoked SD in vivo. Microdialys...

journal_title：Brain research

authors： Taylor DL,Urenjak J,Zilkha E,Obrenovitch TP

更新日期：1997-08-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNFalpha) affects several CNS functions such as regulation of sleep, body temperature, and feeding during pathology. There is also evidence for TNFalpha involvement in physiological sleep regulation, e.g., TNFalpha induces sleep and brain levels of TNFalpha increase during prolonged wakefu...

journal_title：Brain research

authors： De A,Krueger JM,Simasko SM

更新日期：2005-08-16 00:00:00

abstract：:Males and females perform differently on a variety of training tasks. In the present study we examined performance of male and female rats while they were trained with a gross motor skill in which they learn to maintain their balance on an accelerating rotating rod (the accelerating rotarod). During training, many ani...

journal_title：Brain research

authors： DiFeo G,Curlik DM 2nd,Shors TJ

更新日期：2015-09-24 00:00:00

abstract：:Nerve growth factor (NGF) treatment, given as a single 200 BU intraocular injection at the time of optic nerve transection, was found to significantly accelerate the retinal ganglion cell response to axotomy in the newt (Notophthalmus viridescens). In the control series the per cent of neurons in the retinal ganglion ...

journal_title：Brain research

authors： Turner JE,Delaney RK

更新日期：1979-08-03 00:00:00

abstract：:In rats under urethane, iontophoretic applications of GABA (30-60 nA) in the str. pyramidale of CA1, showed a rapidly fading inhibitory effect. By contrast, GABA had a well-maintained inhibitory effect in str. radiatum. During iontophoresis of nipecotic acid (30-85 nA) identical applications of GABA in str. pyramidale...

journal_title：Brain research

authors： Dalkara T

更新日期：1986-02-26 00:00:00

abstract：:A quantitative freeze-fracture study of perivascular astrocytic processes in rat cerebral cortex disclosed rapid disintegration of orthogonal arrays of the intramembrane particles in acute global ischemia. The process apparently preceded the development of astrocytic swelling. ...

journal_title：Brain research

authors： Suzuki M,Iwasaki Y,Yamamoto T,Konno H,Yoshimoto T,Suzuki J

更新日期：1984-05-21 00:00:00

abstract：:Using a perifusion culture technique, the pattern of vasopressin release from the suprachiasmatic nucleus was studied in vitro under basal and stimulated conditions. Individual rat suprachiasmatic explants released vasopressin in a rhythmic fashion and these rhythms persisted with a circadian period for up to 4 cycles...

journal_title：Brain research

authors： Earnest DJ,Sladek CD

更新日期：1987-10-06 00:00:00

abstract：:Brief force perturbations were applied 30-120 ms prior to onset of step-tracking forearm movements by normal humans. The perturbations altered the first agonist burst of the movement-related triphasic EMG pattern. Perturbations opposing the movement resulted in an increase in the magnitude of the late part of the firs...

journal_title：Brain research

authors： Brown SH,Cooke JD

更新日期：1981-09-14 00:00:00