Co-localization of enkephalin and cholecystokinin in discrete areas of rat brain.

Abstract:

:A double-label immunofluorescence technique was used to demonstrate that immunoreactivities for the functionally antagonistic neuropeptides enkephalin and cholecystokinin octapeptide (CCK) are co-localized within individual neurons and processes in discrete areas of rat midbrain and forebrain. Coexistence was most prominent within varicose pericellular axons extending from the periaqueductal gray matter to a field overlying the medial lemniscus, axons and terminal-like puncta in the central medial, paracentral, interanterodorsal and ventral anterior thalamic nuclei, and perikarya and proximal axonal fragments in layers II and III of neo- and allocortex, and in the anterior olfactory nucleus. The former two systems of axons lie in areas of spinothalamic tract termination. These data suggest that some of the antagonism of opioid analgesia by CCK occurs at the synaptic level in nociceptive areas of brain-stem and thalamus where CCK and enkephalin are co-localized and presumably co-released.

journal_name

Brain Res

journal_title

Brain research

authors

Gall C,Lauterborn J,Burks D,Seroogy K

doi

10.1016/0006-8993(87)90085-0

subject

Has Abstract

pub_date

1987-02-17 00:00:00

pages

403-8

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(87)90085-0

journal_volume

403

pub_type

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