Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats.

Abstract:

:The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage.

journal_name

Brain Res

journal_title

Brain research

authors

Belayev L,Saul I,Huh PW,Finotti N,Zhao W,Busto R,Ginsberg MD

doi

10.1016/s0006-8993(99)01952-6

subject

Has Abstract

pub_date

1999-10-16 00:00:00

pages

107-11

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)01952-6

journal_volume

845

pub_type

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