Abstract:
:Lavender belongs to the family Labiatae and has a variety of cosmetic uses as well as therapeutic purposes in herbal medicine. The present study was conducted to evaluate the protective effect of lavender oil against brain edema and its possible mechanisms in an experimental model of stroke. Under Laser-Doppler Flowmetry, focal cerebral ischemia was induced by the transient occlusion of the middle cerebral artery for 1h in rats. Lavender oil (100, 200, and 400 mg/kg ip (and/or vehicle was injected at the onset of ischemia. Infarct size, cerebral edema, functional outcome, and oxidative stress biomarkers were evaluated using standard methods. Western blotting was used to determine the protein expression of VEGF, Bax, and Bcl-2. Treatment with lavender oil at doses of 200 and 400 mg/kg significantly diminished infarct size, brain edema, and improved functional outcome after cerebral ischemia (P<0.001). Lavender oil (200 mg/kg) also reduced the content of malondialdehyde and increased the activities of superoxide dismutase, glutathione peroxidase, and total antioxidant capacity (P<0.001). Although lavender oil enhanced VEGF expression (P=0.026), it could not decrease the Bax-to-Bcl-2 ratio (pro- to anti-apoptotic proteins) in the rat brain (P>0.05). The results indicated that lavender oil has neuroprotective activity against cerebral ischemia and alleviated neurological function in rats, and the mechanism may be related to augmentation in endogenous antioxidant defense, inhibiting oxidative stress, and increasing VEGF expression in the rat brain. However, lavender oil could not suppress the apoptosis pathway.
journal_name
Brain Resjournal_title
Brain researchauthors
Vakili A,Sharifat S,Akhavan MM,Bandegi ARdoi
10.1016/j.brainres.2013.12.019subject
Has Abstractpub_date
2014-02-22 00:00:00pages
56-62eissn
0006-8993issn
1872-6240pii
S0006-8993(13)01590-4journal_volume
1548pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Ablation of tissue regions, specific genes, or specific cell types represent important means of studying function in the nervous system. Here we summarize recent experience using a strategy for the genetically-targeted and conditionally regulated ablation of astroglial cells in different parts of the nervous system. T...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/s0006-8993(99)01639-x
更新日期:1999-07-17 00:00:00
abstract::To determine if aging in rats is associated with insensitivity of cerebral tissue to thyroid hormones (TH), the expression of a TH responsive protein or (THRP) in cerebral tissue was studied in male Fischer rats at 4, 12 and 24 months of age during euthyroid, hypothyroid and hyperthyroid states. The basal levels of TH...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00144-9
更新日期:1998-05-18 00:00:00
abstract::Since several different pathways are involved in cerebral ischemia/reperfusion injury, combination therapy rather than monotherapy may be required for efficient neuroprotection. In this study, we examined the protective effects of an apoptosis inhibitor Gly(14)-humanin (HNG) and a necroptosis inhibitor necrostatin-1 (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.080
更新日期:2010-10-08 00:00:00
abstract::The effects of glucagon injections (25, 100 and 200 ng) into the paraventricular nucleus of the hypothalamus (PVN) were investigated in an open-circuit calorimeter. Wistar rats were tested, with no food available during the tests. High doses of glucagon (100 and 200 ng) produced small and short-lasting increases in en...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90663-8
更新日期:1993-12-10 00:00:00
abstract::The effects of the serotonin precursor 5-HTP, were determined in a behavioral DNIC paradigm (increase in vocalization threshold after intraperitoneal injection of the algogenic agent, phenylbenzoquinone). This counter-irritation phenomenon was strongly potentiated by 5-HTP, such potentiation being blocked by the 5-HT ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90384-5
更新日期:1982-01-14 00:00:00
abstract::The aim of the present study was to investigate the anxiolytic effects of long-term treatment with fluoxetine in rats. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are used to treat anxiety and panic disorders, in addition to treating depression. A major concern with SSRIs is a 2-3-week delay i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02289-1
更新日期:2000-02-07 00:00:00
abstract::The dentate-interpositus nuclei of the cerebellum are known to be critically involved in the production of the classically conditioned eyeblink response in the rabbit. The rostro-medial portions of the inferior olivary complex (rmIO) project to these nuclei as well as receive projections from the fifth sensory nuclei....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91419-2
更新日期:1985-12-16 00:00:00
abstract::The development of glial precursor cells in the mammalian optic nerve depends on retinal ganglion cell (RGC) axons, but the signals that mediate this neuron-to-glia interaction have not been fully characterized. Sonic hedgehog (Shh) is expressed by RGCs, and we showed previously that it is required for the specificati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.06.058
更新日期:2008-09-04 00:00:00
abstract::The particular vulnerability of hippocampal CA3/CA4 neurons to intracerebroventricularly administered kainate did not occur in rats until postnatal day 16. Glutamate applied in the same way failed to show comparable neurodegenerative signs, even when administered in large doses to adult animals. Alternatively, both ka...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90004-x
更新日期:1984-05-01 00:00:00
abstract::From previous inverse dynamic analyses of human leg extensions, it was hypothesized that the underlying processes for the activation of mono- and biarticular muscles are different; the mono-articular muscles being activated when they shortened, whereas the biarticular muscles appeared responsible for the control of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01327-3
更新日期:1997-03-21 00:00:00
abstract::This study was performed to understand the anatomical substrates of hypothalamic modulation of jaw movements. After cholera toxin B subunit (CTb) injection into the parvicellular reticular formation (RFp) of the rat medulla oblongata, where many trigeminal premotor neurons have been known to exist, numerous CTb-labele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.09.076
更新日期:2008-12-09 00:00:00
abstract::Dysfunction in the hypothalamic GABAergic system has been implicated in panic syndrome in humans. Furthermore, several studies have implicated the hypothalamus in the elaboration of pain modulation. Panic-prone states are able to be experimentally induced in laboratory animals to study this phenomenon. The aim of the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.096
更新日期:2009-12-11 00:00:00
abstract::To determine possible mechanisms by which NFTs are formed in Alzheimer's disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombinant tau proteins into insoluble filamentous structures. TGase derived from guinea pig liver was activated by calcium to catalyze the in vitro cr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01121-3
更新日期:1997-01-16 00:00:00
abstract::Administration of methyl palmoxirate (MP), an inhibitor of fatty acid oxidation, stimulates eating behavior in rats. Fos immunohistochemistry was used to determine neural pathways that may play a role in the eating response to MP. The number of cells showing Fos-like immunoreactivity (Fos-li) was quantified by compute...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01143-8
更新日期:1998-01-19 00:00:00
abstract::1-(p-Bromobenzoyl)-piperazine-2,3-dicarboxylic acid (pBB-PzDA; 0.03-5 mM), an excitatory amino acid antagonist, was perfused through the guinea pig cochlea while monitoring various cochlear potentials. pBB-PzDA (1-5 mM) reversibly suppressed the amplitude of the compound action potential of the auditory nerve (CAP) an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90934-7
更新日期:1989-05-15 00:00:00
abstract::The distribution of cerebellar [3H]flunitrazepam binding sites was studied autoradiographically in Purkinje cell degeneration (pcd/pcd), weaver (wv/wv), staggerer (sg/sg) and reeler (rl/rl) mutant mice. In the normal 78-day-old C57BL/6J mouse cerebellum, the highest concentration of [3H]flunitrazepam binding sites was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90920-1
更新日期:1988-03-15 00:00:00
abstract::In in vitro slices prepared from rat sensorimotor cortex, intracellular recordings were obtained from 107 layer V pyramidal neurons, subsequently injected with biocytin for morphological reconstruction. Of the 107 neurons, 59 (55.1%) were identified as adapting (45) or non-adapting (13) regular spiking neurons (RS), a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00807-3
更新日期:1995-10-23 00:00:00
abstract::The activities of 5'-nucleotidase (EC 3.1.3.5) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) (EC 3.1.4.37) were measured in crude membrane preparations from 6 brain regions of hypothyroid rats 31 days and 42 days after conception (8-9 days and 19-20 days after birth respectively) and from normal rats 31, 36...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90185-2
更新日期:1983-04-01 00:00:00
abstract::Diurnal changes in the intranuclear release of vasopressin (VP) and oxytocin (OT) in the suprachiasmatic (SCN), paraventricular (PVN) and supraoptic nuclei (SON) of the rat were studied by means of brain microdialysis. A significant diurnal variation in VP release in the SCN was detected, with the highest levels occur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00324-j
更新日期:1995-06-05 00:00:00
abstract::Previous studies have indicated that amyloid precursor protein (APP) might be a trophic agent in the nervous system, possibly through the regulation of cell adhesion and the protease/protease inhibitor activity. Additionally, APP is upregulated during the development of the nervous system. In order to further study th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91329-d
更新日期:1992-10-16 00:00:00
abstract::A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00816-0
更新日期:1997-10-17 00:00:00
abstract::Electrical self-stimulation in the lateral hypothalamus was recorded in both hemispheres of 20 rats before and after making a lesion either by unilateral radiofrequency stimulation or by injection of N-methyl-D,L-aspartate into the region of the peduncular-pontine nucleus. For the animals which received the radiofrequ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90836-6
更新日期:1989-05-22 00:00:00
abstract::Rats with hippocampal dialysis probes were treated with DL-fenfluramine (FEN), fluoxetine, or FEN with fluoxetine pre-treatment. FEN (12.5 mg/kg) increased extracellular serotonin (5-HT) from 0.4 +/- 0.04 to 25.2 +/- 4.16 pg/10 microliters. Fluoxetine (10.0 mg/kg) increased extracellular 5-HT levels from 0.4 +/- 0.05 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91249-e
更新日期:1992-07-10 00:00:00
abstract::Xenopus laevis tadpoles functionally recover from spinal cord transection. Because this recovery requires the tadpole to metamorphose, it may result from compensatory changes initiated by de novo growth of axons involved in limb dominant locomotion rather than from regeneration of cut axons. To determine whether axona...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.02.126
更新日期:2006-05-09 00:00:00
abstract::10-fold higher doses in SW mice. Furthermore, cotreatment of 129/SvEv mice with morphine plus a low dose of naltrexone (ca. 0.1 microgram/kg) that markedly enhances and prolongs morphine's antinociceptive effects in SW mice did not enhance, and often attenuated6 h. The marked GM1-induced attenuation of morphine's anti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02446-4
更新日期:2000-02-21 00:00:00
abstract::This study examined the spatial organization of corticotropin-releasing factor (CRF) immunopositive climbing fibers in the mouse cerebellum by whole mount immunohistochemistry. A striking pattern of parasagittal stripes of CRF staining was revealed. Cryosections of whole mount CRF stained cerebellum showed that anti-C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.029
更新日期:2008-07-30 00:00:00
abstract::The mesocorticolimbic circuitry has been implicated in the pathophysiology of several neuropsychiatric syndromes like chronic pain and addiction. The aim of this study was to evaluate the effects of dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on sensorimotor behaviors and t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02988-3
更新日期:2003-08-15 00:00:00
abstract::The effect of lung inflation on the excitability of inspiratory neurons of the dorsal respiratory group was studied in decerebrate, paralyzed, artificially ventilated cats. Variations in the antidromic latency (AL) were used as a measure of the changes in excitability. The antidromic responses of single cells were rec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91278-3
更新日期:1986-02-26 00:00:00
abstract::Murine cortical cell cultures deprived of glucose for 6-8 h developed extensive neuronal degeneration, apparent both morphologically and by efflux of lactate dehydrogenase to the bathing medium. This neuronal damage could be substantially reduced by addition of D-2-amino-5-phosphonovalerate (D-APV), in a concentration...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90179-0
更新日期:1989-04-03 00:00:00
abstract::The primary objective of this study was to test the hypothesis that intravenous administration of autologous bone marrow cells could improve functional recovery after middle cerebral artery occlusion (MCAO) for 45 min in the rat and to determine specific time windows for efficacy. Mononuclear cells from autologous bon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.084
更新日期:2004-05-08 00:00:00