Abstract：
:Aggression is a major source of social stress with negative effects on health and well-being, yet limited information is known about the molecular mechanisms mediating aggressive behavior in swine. Ractopamine (RAC) is a β-adrenoreceptor agonist that enhances growth but increases aggressive behaviors in female pigs. Thus, the effects of RAC, sex, and social rank on the mRNA abundance of genes encoding serotonin and dopamine receptors, and monoamine oxidase (MAO)-A in brains of sub-adult pigs were evaluated. Top dominant and bottom subordinate pigs (16/sex) in pens of 4 pigs were determined, and fed either the control or RAC diets. At day 31, their raphe nuclei (RN), amygdala (AMY), frontal cortex (FC), and hypothalamus (HYP) were dissected; relative mRNA abundance for 5-HT₁(B), 5-HT₂(A), 5-HT₂(B), and D₁ receptors, and MAO-A was determined by Q-RT-PCR and data subjected to multivariate linear mixed model analysis and Tukey post-hoc test. Expression of 5-HT₁(B) and MAO-A was suppressed in the AMY of female pigs; 5-HT₂(B) expression was also suppressed in the RN, FC and HYP of females and RN of dominant pigs (P < 0.05). Expression of 5-HT₂(A) was more up-regulated in RN of females compared to males (P < 0.05). Expression of D₁ varied in RN and FC mostly as a function of RAC feeding and its interaction with sex and social rank (P < 0.05). While RAC feeding is related to changes in expression of the D1 receptor mRNA, suppression in expression of serotonergic genes detected in the brain of pigs, especially in females independent of social rank, may be mediating the inter-individual offensive aggression.
journal_name
Brain Resjournal_title
Brain researchauthors
Poletto R,Cheng HW,Meisel RL,Richert BT,Marchant-Forde JNdoi
10.1016/j.brainres.2010.11.035subject
Has Abstractpub_date
2011-03-24 00:00:00pages
11-20eissn
0006-8993issn
1872-6240pii
S0006-8993(10)02548-5journal_volume
1381pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Although astrocytes express gamma-aminobutyric acid subtype-A (GABAA) receptors in the mature brain, GABAA receptor expression in a cultivation state remains controversial. In this study, we investigated the alteration of astrocytic GABAA receptor expression in in vitro and in vivo studies to elucidate the relevance o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.139
更新日期：2006-05-17 00:00:00
abstract：:Whilst the brain-specific benzodiazepine receptor has been assumed to show a late evolutionary appearance, we present evidence for the presence of a central benzodiazepine binding site in sharks, which shows a high affinity for [3H]Ro 15-1788. However, the receptor density and the affinities of several benzodiazepine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90884-0
更新日期：1988-04-19 00:00:00
abstract：:The distribution of substance P (SP) immunoreactivity in the spinal nucleus of the rat trigeminal nerve and in the skin of the lower lip was examined following (a) unilateral electrolytic lesions of the trigeminal ganglion, (b) trigeminal rhizotomy, and (c) unilateral interruption of the mental nerve, the sensory bran...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)91105-8
更新日期：1978-09-08 00:00:00
abstract：:In pericruciate cortex-ablated 'pyramidal cats', discharge changes in single neurons of ventral thalamic nuclei were studied, following stimulation of ipsilateral medullary (MPT) and contralateral cervical (CPT) pyramidal tract. It was seen that cells in ventrolateral nucleus, ventroanterior nucleus and ventromedial n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90187-7
更新日期：1983-11-21 00:00:00
abstract：:A double-label immunofluorescence technique was used to demonstrate that immunoreactivities for the functionally antagonistic neuropeptides enkephalin and cholecystokinin octapeptide (CCK) are co-localized within individual neurons and processes in discrete areas of rat midbrain and forebrain. Coexistence was most pro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90085-0
更新日期：1987-02-17 00:00:00
abstract：:In order to analyze the mechanism of burst discharges intracellular recordings were made from 27 somatosensory thalamic reticular (S-TR) neurons in urethane-anesthetized rats. Burst discharges, composed of 2-7 spikes, were always superposed on a slow depolarization (SD) lasting for 40-60 ms, which appeared only when t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90539-8
更新日期：1989-03-13 00:00:00
abstract：:In 16-week-old Sprague-Dawley rats lightly anesthetized with pentobarbital, 5-HT (3-96 micrograms/kg, i.v.; n = 6) produced distinct pseudaffective responses and a dose-dependent (slope = 17.2 +/- 6.8 s/log10 dose) inhibition of the tail-flick (TF) reflex (ED50 = 32.6 +/- 9.2 micrograms/kg). In the same rats, a 1:1 co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90749-l
更新日期：1991-10-04 00:00:00
abstract：:Distribution of somatostatin (SS) immunoreactivity was observed in the preoptic-anterior hypothalamus (PO-AH) of the female rat brain. Six specific rabbit antibodies A (SS-14), B (SS-28), C (SS-28 complete), D (SS 14 and SS-28 both), E (SS preprohormone) and F (GHRH) were used for immunostaining using Avidin-Biotin Co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03164-4
更新日期：2001-05-11 00:00:00
abstract：:The dorsal column and its nuclei exhibit a considerable number of fibers containing neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP), whose origins and functional roles are as yet unknown. The present study attempts to determine the origin and nature of these fibers by means of immuno...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91225-0
更新日期：1989-08-21 00:00:00
abstract：:The effects of a wide range of doses of systemically administered cysteamine were studied on locomotor behavior, passive avoidance memory, cortical and cerebrospinal fluid somatostatin-like immunoactivity and cortical levels of dopamine and norepinephrine. High doses of cysteamine (200 and 250 mg/kg s.c.) led to susta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90060-6
更新日期：1987-02-17 00:00:00
abstract：:The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147069
更新日期：2020-12-01 00:00:00
abstract：:To determine whether the paraventricular nucleus (PVN) contributes to the development of hypertension in spontaneously hypertensive rats (SHR), we compared cardiovascular responses to ganglionic blockade with hexamethonium or vasopressin antagonism with dPVAVP in sham-operated or PVN lesioned SHR and Wistar-Kyoto rats...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90040-3
更新日期：1991-03-15 00:00:00
abstract：:We have developed a cell culture system for the rat suprachiasmatic nucleus, in which a clear circadian oscillation of vasopressin release was observed. Using this culture system, the effect of anisomycin, an inhibitor of protein synthesis, on the circadian rhythm was studied. A phase-delay of more than 15 h could be ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00414-l
更新日期：1995-07-03 00:00:00
abstract：:Using site-specific antibodies, we assessed the effect of aggregation of various length forms of A beta on the immunoreactive profile of the peptides. All of the antibodies tested reacted with monomeric/dimeric forms of A beta 1-42 and its further aggregates. However, antibodies directed against the 1-24 region of A b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01195-1
更新日期：1995-12-12 00:00:00
abstract：:Examination of the projection from area 2 of the sensory cortex to the motor cortex revealed substantial changes following lesion of the ventrolateral nucleus of the thalamus. These observed changes were as follows. (1) The polarity of the evoked potentials elicited by area 2 stimulation reversed in the depth of the m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90838-8
更新日期：1985-10-14 00:00:00
abstract：:Superfusion of rat hypothalamic slices with 10(-4) M N-methyl-D-aspartic acid (NMDA) resulted in increased release of alpha-melanocyte-stimulating hormone (alpha-MSH). Peptide release was blocked by 10(-6) M NG-nitro-L-arginine methyl ester (L-NAME) a specific competitive inhibitor of nitric oxide synthase but not by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90773-0
更新日期：1994-12-15 00:00:00
abstract：:Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90284-5
更新日期：1981-08-24 00:00:00
abstract：:Homogenates of rat ventral and dorsal spinal cords were subjected to differential and gradient centrifugation on linear sucrose gradients following lysis of a synaptosomal fraction. The distribution of calcitonin gene-related peptide (CGRP) and substance P (SP) in dorsal spinal cord as well as the distribution of sero...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90780-4
更新日期：1989-10-16 00:00:00
abstract：:The responses of single neurons in the insular cortex to electrical stimulation of the chorda tympani (CT), lingual-tonsillar branch of the glossopharyngeal (LT-IXth) nerve, pharyngeal branch of the glossopharyngeal (PH-IXth) nerve, and superior laryngeal (SL) nerve were recorded in anaesthetized and paralyzed rats. N...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00483-6
更新日期：1997-07-25 00:00:00
abstract：:The synaptic protein alpha-synuclein is found throughout the brain, although its function remains ill-defined. Abnormal accumulations of alpha-synuclein have been recognised to be associated with a number of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Nevertheless, little is know...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.072
更新日期：2004-04-09 00:00:00
abstract：:Hypoxia markedly depresses synaptic transmission in hippocampal slices of the rat. This depression is attributed to presynaptic inhibition of glutamate release and is largely mediated by adenosine released during hypoxia acting through presynaptic adenosine A(1) receptors. Paired pulse facilitation studies allowed us ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02381-7
更新日期：2000-06-30 00:00:00
abstract：:The effects of omega-conotoxin (CTX) GVIA, omega-agatoxin (Aga) IVA, and the dihydropyridine nicardipine were studied on synaptic transmission in the hippocampus during aging. Field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 region in slices from young and aged Fischer 344 rats. Peptide toxin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01234-6
更新日期：1997-01-16 00:00:00
abstract：:The effect of ciliary neurotrophic factor (CNTF) on peripheral nerve regeneration was studied in 6-week-old rats following sciatic nerve transection and juxtaposition of proximal and distal stumps. Rats received intraperitoneal recombinant human CNTF, 1 mg/kg every other day for 12 days. In all CNTF-treated animals, t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91621-7
更新日期：1994-08-29 00:00:00
abstract：:Following electrophysiological techniques we investigated whether wallerian degeneration of the cat sural nerve may be influenced by (1) its peripheral connection and (2) the distance from the cell body. Distal stumps connected to their innervation sites peripherally showed less degeneration than proximal ones when is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91332-b
更新日期：1990-08-13 00:00:00
abstract：:The capacity of the dopaminergic nerve system to reinnervate the denervated adult striatum was analyzed in a model of partial 6-hydroxydopamine-induced unilateral lesion of rat substantia nigra pars compacta. Sprouting of dopaminergic fibers entering the ventrolateral part of the striatum from a narrow zone of the ext...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01391-1
更新日期：1996-02-19 00:00:00
abstract：:Intracellular and extracellular recordings from CA3 hippocampal neurons in vitro were used to study the ability of several NMDA (N-methyl-D-aspartate) receptor antagonists to suppress epileptiform bursts induced by NMDA and convulsants not thought to act at NMDA receptors. The antagonists, APV (D-2-amino-5-phosphonova...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90642-7
更新日期：1988-09-06 00:00:00
abstract：:Antibodies binding to the 150 kDa neurofilament protein NF150 have been purified from a serum raised by immunizing a rabbit with alpha-MSH. The NF150-binding antibodies were purified by affinity chromatography on a column of cytoskeletal proteins coupled to CNBr-activated Sepharose-4B. Immunocytochemical application o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91365-5
更新日期：1987-02-24 00:00:00
abstract：:In freely-moving rats treated with a combination of reserpine (10 mg/kg, i.p.) and scopolamine (5 mg/kg, i.p.), neocortical low voltage fast activity (LVFA) associated with continuous multiunit activity (MUA) was abolished and replaced by 2-6 Hz large irregular slow activity (LISA) above 1.5 mV associated with a burst...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00396-4
更新日期：1996-07-29 00:00:00
abstract：:The effects of brain and meningeal extracts from chick embryos on the proliferation of cultured neuroblasts from chick embryo cerebral hemispheres were studied. Morphological observations, counts of the cultured neurons, determination of DNA and protein contents as well as [3H]thymidine incorporation measurements were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90073-0
更新日期：1981-06-01 00:00:00
abstract：:Mouse embryonic stem (ES) cells were transplanted into the cochlea of adult guinea pigs in order to explore their survival, differentiation, and possible integration with the host tissue. With the purpose of investigating the possible effect of manipulating the local embryonic microenvironment, ES cells were transplan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.016
更新日期：2005-07-27 00:00:00
