Abstract:
:The capacity of the dopaminergic nerve system to reinnervate the denervated adult striatum was analyzed in a model of partial 6-hydroxydopamine-induced unilateral lesion of rat substantia nigra pars compacta. Sprouting of dopaminergic fibers entering the ventrolateral part of the striatum from a narrow zone of the external capsule was detected on the lesioned side 4 and 7 months, but not 10 days, after lesioning. Ultrastructural examination of the zone of sprouting revealed hypertrophic dopaminergic fibers and growth-cone-like structures, confirming the existence of an ongoing process of spontaneous regrowth of dopaminergic fibers. The identification of the factors involved in the regrowth of dopaminergic fibers may help to orientate molecular research into new treatments for Parkinson's disease.
journal_name
Brain Resjournal_title
Brain researchauthors
Blanchard V,Anglade P,Dziewczapolski G,Savasta M,Agid Y,Raisman-Vozari Rdoi
10.1016/0006-8993(95)01391-1subject
Has Abstractpub_date
1996-02-19 00:00:00pages
319-25issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(95)01391-1journal_volume
709pub_type
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