Dopaminergic sprouting in the rat striatum after partial lesion of the substantia nigra.

Abstract:

:The capacity of the dopaminergic nerve system to reinnervate the denervated adult striatum was analyzed in a model of partial 6-hydroxydopamine-induced unilateral lesion of rat substantia nigra pars compacta. Sprouting of dopaminergic fibers entering the ventrolateral part of the striatum from a narrow zone of the external capsule was detected on the lesioned side 4 and 7 months, but not 10 days, after lesioning. Ultrastructural examination of the zone of sprouting revealed hypertrophic dopaminergic fibers and growth-cone-like structures, confirming the existence of an ongoing process of spontaneous regrowth of dopaminergic fibers. The identification of the factors involved in the regrowth of dopaminergic fibers may help to orientate molecular research into new treatments for Parkinson's disease.

journal_name

Brain Res

journal_title

Brain research

authors

Blanchard V,Anglade P,Dziewczapolski G,Savasta M,Agid Y,Raisman-Vozari R

doi

10.1016/0006-8993(95)01391-1

subject

Has Abstract

pub_date

1996-02-19 00:00:00

pages

319-25

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(95)01391-1

journal_volume

709

pub_type

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