Abstract：
:In order to analyze the mechanism of burst discharges intracellular recordings were made from 27 somatosensory thalamic reticular (S-TR) neurons in urethane-anesthetized rats. Burst discharges, composed of 2-7 spikes, were always superposed on a slow depolarization (SD) lasting for 40-60 ms, which appeared only when the membrane was hyperpolarized. The number of spikes superposed on an SD varied depending upon the amplitude of the SD. A single shock stimulation of the lemniscus medialis elicited a series of SDs, each without being preceded by a phasic hyperpolarizing potential. The SDs were repeated with spindle rhythms. Evidence has been provided that EPSPs contribute to the mechanism for triggering SDs. In spontaneous rhythmic SDs occurring with the rhythm of EEG spindles, steps representing EPSPs were recordable on the rising phase of each SD. It is suggested that excitatory synaptic inputs to S-TR neurons with the spindle rhythm are responsible for the rhythmic generation of SDs. Ventrobasal relay neurons are presumed as the source of the inputs.
journal_name
Brain Resjournal_title
Brain researchauthors
Sumitomo I,Takahashi Y,Kayama Y,Ogawa Tdoi
10.1016/0006-8993(89)90539-8subject
Has Abstractpub_date
1989-03-13 00:00:00pages
34-41issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90539-8journal_volume
482pub_type
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